Publications by authors named "BoRam Lee"

Various acupuncture clinical trials have been conducted on migraine; however, the conclusions remain controversial especially when acupuncture was compared with sham acupuncture. Sham acupuncture is sometimes performed at the same acupuncture points used for verum acupuncture despite the evidence on acupuncture point specificity. Four databases were searched for sham acupuncture or waiting list-controlled acupuncture trials for migraine on December 25, 2023.

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Background: Although T2 gallbladder cancer (GBC) incidentally diagnosed after cholecystectomy requires additional resection, the surgical approaches are technically difficult due to inflammatory adhesion or fibrosis around the hepatoduodenal ligament and gallbladder bed. In this study, we sought to compare the surgical and oncologic outcomes of open and minimally invasive reoperation for postoperatively diagnosed T2 GBC.

Study Design: Patients who underwent open (n = 110) and laparoscopic (n = 38) reoperation for T2 GBC between November 2004 and October 2022 at five tertiary referral centers were included in this multicenter retrospective cohort study.

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Aqueous zinc-ion batteries (AZIBs) are highly attractive as energy-storage systems owing to their inherent safety, low cost, and simple assembly processes. However, the growth of Zn dendrites and side reactions at the Zn metal anode significantly degrade their electrochemical performance. To address these challenges, this study introduces a surface modification that increases the lifespan and cycling stability of AZIBs by constructing an artificial zinc sulfide (ZnS) protective layer on the Zn anode.

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Objective: To examine disparities in trends of smoke-free home (SFH) rule prevalence in the United States from 2001 to 2019 by individuals' number of socioeconomic disadvantages.

Methods: Data were drawn from the 2001-2019 Tobacco Use Supplements to the U.S.

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: Hwa-byung (HB), also known as "anger syndrome" or "fire illness", is a culture-bound syndrome primarily observed among Koreans. This study aims to develop a short-form version of the HB symptom scale using machine learning approaches. Methods: Utilizing exploratory factor analysis (EFA) and various machine learning techniques (i.

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Introduction: Numerous studies have suggested high concordance between tissue and circulating tumor DNA (ctDNA) comprehensive genomic profiling (CGP) tests but only few of them focused on fusions. In addition, atypical breakpoints occasionally detected from DNA-based fusion detection make interpretation difficult, and their clinical significance remains unclear. This study evaluated the clinical utility of ctDNA CGP for fusion detection.

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Objective: Sham acupuncture has been used as a control in acupuncture efficacy trials. However, questions have been raised about whether it is a physiologically inert placebo. We aimed to understand global research trends and provide guidance for future research by conducting a bibliometric analysis of sham acupuncture studies.

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Introduction: High tobacco smoking prevalence in people with low SES or serious psychological distress in the U.S. may increase cardiovascular disease risk among these marginalized subpopulations.

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Article Synopsis
  • Extremely well-differentiated gastric-type adenocarcinoma (EWDGA) is a rare gastric cancer that often mimics normal stomach tissue, which can lead to misdiagnosis.
  • In a study involving 11 pathologists evaluating six preoperative biopsies, the diagnosis of malignancy was only confirmed in 15.2% of cases, highlighting significant diagnostic challenges.
  • Despite minimal atypia in biopsy samples and no overexpression of the p53 protein, genomic profiling revealed mutations associated with more aggressive cancer, emphasizing the need for better recognition and diagnostic practices for EWDGA.
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  • Minimally invasive pancreatoduodenectomy (MIPD) techniques, like robot-assisted (RAPD) and totally laparoscopic (TLPD) surgeries, are becoming more popular for treating pancreatic diseases.
  • A study comparing RAPD and TLPD found similar complication rates and survival outcomes, although RAPD was associated with shorter operation times and hospital stays.
  • The overall results suggest both methods are safe and effective, allowing surgeons to choose based on factors like technique preference, cost, and experience.
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Background/objectives: The prognostic significance of circumferential resection margin (CRM) or circumferential surface (CS) in pancreatic head cancer is controversial. We investigated the survival outcomes according to CRM or CS involvement in pancreatoduodenectomy specimens of pancreatic ductal adenocarcinoma (PDAC).

Methods: A total of 102 pancreatoduodenectomy specimens after upfront surgery for PDAC between 2014 and 2018 were prospectively collected.

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  • Traditional medicine (TM) is important in healthcare and this study aimed to analyze systematic reviews (SRs) of TM modalities to identify gaps in existing research and inform future studies.
  • The researchers conducted a comprehensive search across 17 databases from January 2018 to December 2022, ultimately screening over 181,000 records to include 2,719 relevant SRs focusing mainly on adults and specific health conditions.
  • The study found that most TM research concentrated on herbal medicine and acupuncture for conditions related to the digestive, circulatory, and genitourinary systems, while highlighting low methodological quality of the included SRs as a concern for future TM research efforts.
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Background: There is still poor evidence about the safety and feasibility of laparoscopic liver resection (LLR) for huge (> 10 cm) hepatocellular carcinomas (HCC). The aim of this study was to assess the short- and long-term outcomes of LLR versus open liver resection (OLR) for patients with huge HCC from real-life data from consecutive patients.

Methods: Data regarding all consecutive patients undergoing liver resection for huge HCC were retrospectively collected from a Korean referral HPB center.

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Menopausal insomnia significantly impacts the quality of life in women. East Asian herbal medicines (EAHMs) have been traditionally used in Asian countries, but their efficacy and safety require systematic evaluation. This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of EAHM for treating menopausal insomnia.

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Background: Obesity imposes a significant socioeconomic burden owing to its high prevalence. In response to the adverse outcomes associated with conventional pharmacotherapy and the challenges of low adherence to lifestyle interventions, herbal medicine has surfaced as an actively utilized approach for weight loss. Therefore, this study aimed to analyze the characteristics and influencing factors of herbal medicine users for weight loss in adults.

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The objective of this study was to explore the key elements of Korean medicine (KM) treatment for idiopathic short stature (ISS) by analyzing the strengths, weaknesses, opportunities, and threats (SWOT). This was a qualitative study of interviews with 7 KM doctors who had at least 3 years of experience in KM treatment for ISS. Based on the content, a SWOT and a cross-SWOT analysis were conducted.

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Article Synopsis
  • * Intrathecal (IT) delivery of AAV vectors can bypass some of these problems but has limitations in distribution and potential liver toxicity.
  • * Researchers identified improved AAV capsids through testing in non-human primates, which demonstrated better retention in the spinal cord and lower distribution to the liver, making them promising candidates for spinal cord gene therapies compared to traditional AAV9.
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  • - EGFR exon 20 insertion mutations (E20ins) are commonly found in non-small cell lung cancer, making up 1-10% of total EGFR mutations, but inconsistent naming practices create confusion in research and treatment documentation.
  • - The study collected 1,418 EGFR E20ins mutations from six different studies and found that many needed reclassification, with issues like mislabeling deletions as insertions, and inconsistent annotations even within the same datasets.
  • - The Oncomine Dx Target Test had the best detection coverage at 77.2%, emphasizing the need for standardized genomic annotations (like HGVS) to improve accuracy in identifying variants and drug responses in patients.
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Background: Laparoscopic pancreatic resection is comparable to open pancreatic resection; however, cost-effectiveness analyses of laparoscopic pancreatic resection are scarce. The authors performed a population-based study investigating the cost-effectiveness of laparoscopic pancreatic resection versus open pancreatic resection.

Methods: Data from 9,256 patients who received pancreaticoduodenectomy (66.

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  • CYFIP2 is a protein that influences neuronal development and is linked to how mice respond to cocaine, especially when it has a mutation (S968F).
  • In experiments with mice having this mutation, researchers found reduced sensitivity to cocaine and differences in brain activity and protein expression in regions associated with reward processing.
  • The study suggests that understanding CYFIP2's function could help in developing treatments targeting cocaine-related behaviors.
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Background And Purpose: Methamphetamine (METH) use disorder has risen dramatically over the past decade, and there are currently no FDA-approved medications due, in part, to gaps in our understanding of the pharmacological mechanisms related to METH action in the brain.

Experimental Approach: Here, we investigated whether transient receptor potential ankyrin 1 (TRPA1) mediates each of several METH abuse-related behaviours in rodents: self-administration, drug-primed reinstatement, acquisition of conditioned place preference, and hyperlocomotion. Additionally, METH-induced molecular (i.

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  • The study aimed to develop a four-dimensional (4D) tracking system to accurately locate the Iridium-192 (Ir-192) radiation source used in high-dose rate brachytherapy through time-dependent 3D positioning.
  • The research involved designing a tracking system with six compact detectors and optimizing a diverging collimator, using simulations on the open-source GATE Monte Carlo platform to test its effectiveness.
  • The accuracy of the system was validated through simulations with both a solid phantom and patient data, showing an average Euclidean distance error of approximately 1.146 mm in phantom simulations and 0.586 mm in patient data, indicating promising localization capabilities.
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