Publications by authors named "Bo-yu Tang"

Objective: To investigate the role of periodontitis in the development of oral squamous cell carcinoma (OSCC) and to determine whether periodontitis microorganisms induce M2 macrophage (M2) polarization and promote tumor progression.

Methods: The tumor tissues of OSCC patients with periodontitis and those without periodontitis were collected and immunohistochemistry tests were done to validate the trend of changes in M2 macrophages. A mouse model of OSCC accompanied by periodontitis was established by treating mice with drinking water containing four antibiotics for three consecutive days, applying in the mouths of the mice a coat of bacteria collected from the saliva of patients with periodontitis once every other day for five times, and injecting in their buccal mucosa OSCC cells (SCC7).

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Objective: To study the antibacterial effect of berberine combined with amylmetacresol on .

Methods: Both dilution method and live bacteria CFU were used to determine the minimum inhibitory concentration (MIC) of berberine and amylmetacresol on . The killing effect of berberine and amylmetacresol on planktonic was detected by suspension quantitative germicidal test and live/dead bacteria staining.

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Article Synopsis
  • The study investigates how combining angiotensin-converting enzyme inhibitors (ACEI) with subthreshold preconditioning can protect the heart during ischemia by focusing on mitochondrial potassium channels.
  • The experiment used isolated rat hearts to measure specific enzyme activities and observe the effects of the treatments on heart function during ischemia.
  • Findings indicated that while neither treatment alone was effective, their combination improved heart function and delayed damage, suggesting that mitochondrial potassium channels play a crucial role in this protective mechanism.
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Article Synopsis
  • The study investigated whether angiotensin-converting enzyme inhibitors (ACEIs) could enhance the heart's protective response during ischemia by using a specific rat heart model.
  • In isolation, neither ACEI alone nor a short preconditioning prior to ischemia was effective, but combining them led to improved heart function and reduced damage after prolonged ischemia.
  • The efficacy of the combination treatment was linked to increased nitric oxide levels and was diminished when specific inhibitors targeting those pathways were applied.
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