Publications by authors named "Bo-Yuan Ren"
Article Synopsis
- * A total of 24 patients were split into three groups and given different doses of neorudin, observing that it was safe and well tolerated without serious adverse events during treatment.
- * The results showed that neorudin increased specific blood clotting times and reduced thrombin activity; it remained effective at doses up to 0.45 mg/kg/h over three days, with a half-life of about 2 hours.
Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury.
Drug Des Devel Ther
August 2023
Background: Whether anticoagulant therapy should be used after spinal-cord injury (SCI) surgery was controversial. The anticoagulation characteristics of a newly developed anticoagulant, recombinant neorudin (EPR-hirudin (EH)), were explored using a rat model of SCI to provide a basis for clinical anticoagulation therapy of SCI.
Methods: A rat model of SCI was developed by Allen's method.
In this study, the toxicity effects on circulatory system and respiratory system, and the acute toxicity test of recombinant neorudin (EPR-hirudin, EH) in cynomolgus monkeys were evaluated to provide reference information for clinical studies. Eighteen cynomolgus monkeys were randomly divided into three groups for single intravenous administration of 3, 30 mg/kg EH and normal saline, respectively. The changes of respiratory frequency, respiratory intensity, blood pressure and electrocardiogram before and after administration were recorded.
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