Publications by authors named "Bo-Yi Lei"
Clin Rheumatol
March 2021
Article Synopsis
- Osteoarthritis (OA) is the most common joint disorder and major cause of disability, with a notable genetic influence alongside aging and obesity, prompting this study to explore the relationship between GLIS3 and GLIS3-AS1 gene variants and knee OA risk in a Chinese population.
- A case-control analysis involving 810 knee OA patients and 900 healthy individuals evaluated seven specific SNPs, revealing that certain minor alleles were significantly linked to a lower risk of developing knee OA.
- The study concluded that genetic variants of GLIS3 and GLIS3-AS1 play a crucial role in knee OA, highlighting specific alleles associated with decreased disease risk and their effects on gene expression in joint tissues.
