Publications by authors named "Bo-Yan Fang"
Article Synopsis
- The study investigates whether transcranial alternating current stimulation (tACS) combined with multidisciplinary intensive rehabilitation treatment (MIRT) can improve symptoms and enhance quality of life for patients with Parkinson's disease (PWP) by modulating brain activity.
- It is a randomized, double-blind trial involving 60 participants aged 45 to 70, assigned to either the tACS+MIRT group or a sham-tACS group, with assessments done over a 26-week period.
- The results aim to show that tACS may boost functionality and correlate with changes in specific Parkinson’s disease measurement scores, supporting the therapeutic effects of combined treatment.
To investigate the association between autonomic dysfunction (AutD) and motor as well as non-motor symptoms (NMS) in patients with Parkinson's disease (PD). Fifty-three PD patients were divided into two groups based on the number of domains affected by AutD: a multi-domain AutD group (AutD-M) and a single-domain AutD group (AutD-S), as evaluated using the Scale for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT), which assesses autonomic symptoms, one of the NMS. A comprehensive comparison was conducted between the two groups, including clinical measures such as clinical scales, quantitative evaluations of motor function and exercise capacity.
View Article and Find Full Text PDFObjective: To summarize the efficacy of wearable cueing devices for improving gait and motor function of patients with Parkinson disease (PWP).
Data Sources: PubMed, Embase, and Cochrane CENTRAL databases were searched for papers published in English, from inception to October 23, 2022.
Study Selection: Randomized controlled trials focusing on the effects of wearable cueing devices on gait and motor function in PWP were included.
Article Synopsis
- Researchers are testing a new treatment for people with Parkinson's disease by combining a brain stimulation method called iTBS with regular physical therapy to see if it helps them move better and feel healthier.
- The study will include 50 patients aged 45-70, who will be split into two groups: one will get iTBS with physiotherapy, and the other will get a pretend version (sham) of iTBS with physiotherapy.
- They will watch how well the treatments work over 24 weeks, using different tests to measure improvements in movement and life quality.
Patients with Parkinson's Disease presented gait impairment. Applying additional weights to enhancing sensory input may improve gait impairment. We assumed that gait impairment could be improved when patients walked with additional forearm weights, and the gait improvement was associated with clinical characteristic of Parkinson's Disease.
View Article and Find Full Text PDFBackground And Purpose: Orthostatic hypotension (OH) is common in patients with Parkinson's disease (PD). Early recognition OH is required with sensitive assessments. The purpose of this study was to determine whether blood pressure (BP) changes during exercise can predict the occurrence of OH in PD.
View Article and Find Full Text PDFIn normal subjects, the diaphragm plays a key functional role in postural stability, articulation, respiration, defecation, and urination. The aim of this study was to investigate the role of the diaphragm in postural stability and visceral function in patients with Parkinson's disease (PD) and to compare the diaphragm function by gender, Hoehn and Yahr (H&Y) staging, and motor subtypes. In total, 79 patients were enrolled in this cross-sectional study.
View Article and Find Full Text PDFParkinson's disease (PD) can be classified into three motor-based subtypes: postural instability/gait difficulty (PIGD), tremor dominant (TD), and indeterminate. The neuropathophysiological mechanisms of the three motor subtypes are different, which may lead to different responses to therapy. Sixty-nine patients with idiopathic Parkinson's disease (Hoehn-Yahr stage ≤ 3) were screened from 436 patients with Parkinsonism recruited through outpatient services and the internet.
View Article and Find Full Text PDFBackground: Glial fibrillary acidic protein (GFAP) autoimmune astrocytopathy is characterized by GFAP autoantibody positive encephalitis, meningoencephalitis or meningoencephalomyelitis. The initial clinical presentation may be similar to central nervous system infections making early diagnosis challenging.
Case Presentation: A Chinese female patient presented with subacute meningitis with symptoms of headache, vomiting, and fever.
Background: Two novel presenilin 1 (PS1) mutations, V97L and A136G, were recently found to be involved in the early-onset of Alzheimer's disease in two Chinese families. This research aimed to verify their pathological effects.
Methods: The human neuroblastoma SH-SY5Y cells stably transfected with these two Chinese presenilin 1 mutations were established to explore whether they are sensitive to, or influenced by, serum deprivation and protected by insulin-like growth factor-1 (IGF-1).
Objective: To study the effects of two novel presenilin-1 (PS1) mutations, V97L and A136G, discovered in 2 families of Alzheimer's disease (AD) in China, on human neuroblastoma cells and the protective role of insulin-like growth factor-1 (IGF-1).
Methods: Two mutation type (MT) PS-1 genes with the mutational sites V97L and A136G were established. These 2 MT genes, wild type (WT) PS-1 gene, and mock were stably transfected into the human neuroblastoma cells of the line SH-SY5Y.