[Risk Factors Associated with Thyroid Nodules in Patients with Acromegaly].

Objective: To identify risk factors associated with thyroid nodular lesions in patients with acromegaly.

Methods: Clinical and thyroid ultrasonography data of patients with acromegaly diagnosed in the West China Hospital of Sichuan University from May 2009 to January 2018 were reviewed and analyzed. Multivariate linear regression models were established to identify factors associated with thyroid volumes and size of thyroid nodules.

Intracystic bleomycin for cystic craniopharyngiomas in children.

Background: Craniopharyngiomas are the most common benign histological tumours to involve the hypothalamo-pituitary region in childhood. Cystic craniopharyngiomas account for more than 90% of the tumours. The optimal treatment of cystic craniopharyngioma remains controversial.

Management of large medial sphenoid wing meningiomas: a series of 178 cases.

Aim: The aim of this study was to evaluate our treatment and outcome in patients with large medial sphenoid wing meningiomas (SWMs).

Material And Methods: Data from 178 patients with large medial SWMs treated was collected and analyzed retrospectively. Most of patients underwent microsurgical resection under electrophysiological monitoring and Doppler probe.

Intracystic bleomycin for cystic craniopharyngiomas in children.

Background: Craniopharyngiomas are the commonest benign histological tumours to involve the hypothalamo-pituitary region in childhood. Cystic craniopharyngiomas comprise more than 90% of the tumours. The optimal treatment of cystic craniopharyngioma remains controversial.

Intracystic bleomycin for cystic craniopharyngiomas in children.

Background: Craniopharyngiomas are the commonest benign histological tumours to involve the hypothalamo-pituitary region in childhood. Cystic craniopharyngiomas occur in more than 90% of tumours. The optimal treatment of cystic craniopharyngioma remains controversial.

Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage.

Background: Inflammation and immunity play a vital role in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). Nuclear factor-kappa B (NF-kappaB) regulates many genes essential for inflammation and immunity and is activated by toll-like receptor (TLR). This study aimed to detect the expression of the toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-kappaB) signaling in the rat brain after early SAH.

WITHDRAWN: Activation of TLR4/NF-kappaB signaling pathway in early brain injury after subarachnoid hemorrhage.

Ahead of Print article withdrawn by publisher.

Experience of microsurgical treatment of brainstem cavernomas: report of 37 cases.

Background: Cavernomas are rare in the brainstem and account for 18-35% of central nervous cavernomas and can cause recurrent hemorrhages, devastating neurological deficits and mortality.

Objectives: To summarize the experience of microsurgical treatment of brainstem cavernomas and to investigate curative effect of microsurgical treatment of brainstem cavernomas.

Materials And Methods: A retrospective analysis clinical data of 37 patients with brainstem cavernomas seen between 2003 and 2007.

Microneurosurgical management of the clinoid and paraclinoid aneurysms.

Objective: To evaluate the management of clinoid and paraclinoid aneurysms with modern microneurosurgical techniques and instruments.

Methods: The data of 38 patients with clinoid and paraclinoid aneurysms who underwent microsurgical clipping in the Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China, from 2000 to 2005, were analysed retrospectively.

Results: All 40 aneurysms were treated microneurosurgically, among which 97.

[Micro-neurosurgical treatment of cranionasal tumors in combination with transnasal endoscopy].

Objective: To explore an effective microsurgical approach to the treatment of cranionasal tumors.

Methods: A retrospective review of 18 micro-neurosurgical patients with cranionasal tumors (June 2005 to June 2007) was undertaken.

Results: All of the 18 patients were treated with subfrontal approaches in combination with transnasal endoscopy.

[Expression of CD147 and MMP-2 in human gliomas and its correlations with prognosis].

Objective: To investigate the expressions of CD147 and MMP-2 in human gliomas and to study the relationship between their expression and prognosis.

Methods: Immunohistochemistry SP methods were applied to detect the expression of CD147 and MMP-2 in 50 cases of gliomas and RT-PCR also applied to analyze the expression level of CD147 mRNA. The relationship between the expression level and the glioma prognosis were analyzed statistically depends on the follow-up investigation of the disease development.

[An experimental research on tumor metastasis treated by chicken homologous matrix metalloproteinase-2 vaccine combined with low-dose cisplatin].

Objective: To evaluate the cooperating effect on whether the chicken homologous matrix metalloproteinase-2 (c-MMP-2) vaccine combined with low-dose cisplatin (DDP) can enhance the treatment efficacy of tumor metastasis.

Methods: The eukaryotic expression plasmid encoding chicken homologous MMP-2 was constructed by recombinant DNA technique. In this experiment, the lung metastasis model of murine colon adenocarcinoma (C26) was established in 6- to 8- weeks of age female BALB/c mice, and then treated with 0.

[Changes in P-selectin expression after brain injury in rats].

Objective: To explore the relationship between expression thange of P-selectin after brain injury and secondary brain damage.

Methods: Sixty SD rats were randomized into 3 equal groups, namely the control group, mild injury group and severe injury group and animal models of brain injury were established in SD rats according to the method of Feeney. P-selectin expression in the brain tissues were determined at 6 h and l, 3, and 7 days following brain injury (n=5 for each time point).

Microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach.

Background: Craniopharyngioma of the third ventricle is difficult to treat and its therapeutic regimens and operative approaches have been controversial. This study was undertaken to probe indications for microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach, its surgical procedures and therapeutic effects, and prevention of postoperative complications.

Methods: Fifty-one patients with craniopharyngioma of the third ventricle were treated from January 2000 to October 2004 by an improved transventricular approach for removing the tumor via the interventricular foramen, the intermedius of the septum pellucidum or choroid fissure.

[Therapeutic effect of far lateral approach on the lesions located ventral to cranial-cervical junction].

Objective: To investigate the administration of far-lateral approach in lesions located anterior or anterolateral to brain stem and upper cervical spinal cord.

Methods: Twenty-three patients underwent far lateral approach, including 12 retrocondylar approach, 5 partial transcondylar approach, 3 transfacetal and partial transcondylar approach, 2 transtubercular approach and 1 complete transcondylar approach.

Results: Total tumor removal was achieved in 15 patients, subtotal removal in 5 patients, 3 vertibral artery aneurysms were clipped successfully, 3 patients were given occipitalcervical fusion.

[Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction].

Objective: To investigate the effect of compound Salvia injection (CSI) on blood coagulatory function in patients with traumatic cerebral infarction (TCI).

Methods: Sixty-four patients with TCI were randomly divided into two groups, 32 in each group. The treated group were treated with CSI plus conventional treatment of western medicine, and the control group treated with conventional treatment alone.

[Therapeutic effect of 125IUdR on the glioma cell line C6 in vitro and in vivo].

Objective: To investigate the therapeutic effect of 125IUdR on gliomas.

Methods: By means of growth-curve, clonogenic formation experiment and MTT assay, the inhibitive effect of 125IUdR on the proliferation of C6 cells was studied in vitro. Wistar rats with intracerebral C6 gliomas were used to verify the therapeutic efficacy of 125IUdR in vivo.