Publications by authors named "Bo-Wei Liao"
The proinflammatory cytokine IL-1β is a crucial mediator of inflammatory responses. IL-1β-induced signaling is finely regulated by various mechanisms, and its imbalance is involved in a variety of diseases. In this study, we identified FAM177A1, a protein of unknown function, as a negative regulator of IL-1β-induced signaling in human cells.
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- RIG-I-like receptors (RLRs) detect viral RNAs and activate signaling pathways that lead to the production of type I interferons (IFNs), which help combat viral replication and activate the immune response.
- Dysregulated IFN production is linked to various immune diseases, and this study identifies Signal Recognition Particle 54 (SRP54) as a negative regulator of the RLRs’ antiviral signaling.
- Overexpression of SRP54 blocks IFN-β production and boosts viral replication, while reducing SRP54 levels enhances this immune response by promoting RLR interaction with the adaptor protein VISA.
Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately regulated by various post-translational modifications including polyubiquitination. In this study, we identified the deubiquitinating enzyme USP44 as a positive regulator of MITA.
View Article and Find Full Text PDFThe cytosolic DNA sensor cGAS recognizes viral DNA and synthesizes the second messenger cGAMP upon viral infection. cGAMP binds to the adaptor protein MITA/STING to activate downstream signaling events, leading to induction of type I interferons (IFNs) and antiviral effector genes. Here we identify the human cytomegalovirus (HCMV) protein UL31 as an inhibitor of cGAS.
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