Publications by authors named "Bo-Wei Liao"

The proinflammatory cytokine IL-1β is a crucial mediator of inflammatory responses. IL-1β-induced signaling is finely regulated by various mechanisms, and its imbalance is involved in a variety of diseases. In this study, we identified FAM177A1, a protein of unknown function, as a negative regulator of IL-1β-induced signaling in human cells.

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Article Synopsis
  • RIG-I-like receptors (RLRs) detect viral RNAs and activate signaling pathways that lead to the production of type I interferons (IFNs), which help combat viral replication and activate the immune response.
  • Dysregulated IFN production is linked to various immune diseases, and this study identifies Signal Recognition Particle 54 (SRP54) as a negative regulator of the RLRs’ antiviral signaling.
  • Overexpression of SRP54 blocks IFN-β production and boosts viral replication, while reducing SRP54 levels enhances this immune response by promoting RLR interaction with the adaptor protein VISA.
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Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately regulated by various post-translational modifications including polyubiquitination. In this study, we identified the deubiquitinating enzyme USP44 as a positive regulator of MITA.

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The cytosolic DNA sensor cGAS recognizes viral DNA and synthesizes the second messenger cGAMP upon viral infection. cGAMP binds to the adaptor protein MITA/STING to activate downstream signaling events, leading to induction of type I interferons (IFNs) and antiviral effector genes. Here we identify the human cytomegalovirus (HCMV) protein UL31 as an inhibitor of cGAS.

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