Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge sp.

The marine sponge sp., collected from the Southern waters of Taiwan, was subjected to chemical composition screening, resulting in the isolation of four new 24-homoscalarane compounds, namely lendenfeldaranes R-U (-). The structures and relative stereochemistry of the new metabolites - were assigned based on NMR studies.

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response.

Inflammation is a critical defense mechanism that is utilized by the body to protect itself against pathogens and other noxious invaders. However, if the inflammatory response becomes exaggerated or uncontrollable, its original protective role is not only demolished but it also becomes detrimental to the affected tissues or even to the entire body. Thus, regulating the inflammatory process is crucial to ensure that it is resolved promptly to prevent any subsequent damage.

Capnellenes from : Deciphering Their Anti-Inflammatory-Associated Chemical Features.

Through our ongoing research on investigating new anti-inflammatory terpenoids derived from soft corals, seven capnellenes sourced from were discovered. Among these, three were previously unknown compounds named Δ-capnellene-6α,8β-diol (), Δ-capnellene-6α,8β,10α-triol (), and Δ-capnellene-2β,8β,10α-triol (). The structures of all compounds were determined by spectroscopic analysis (IR, MS, 1D-, and 2D-NMR) and a comparison with the existing literature data.

Chemometric-guided chemical marker selection: A case study of the heat-clearing herb .

The selection of medicinal plants' chemical markers focuses on bioactivity as the primary goal, followed by the nature of secondary metabolites, their stability, and availability. However, herbal medicines are valued for their complex and holistic pharmacological effects. A correct chemical marker can be carefully selected by a systematic clarification of their chemical-biological relationships.

MS/MS Molecular Networking Unveils the Chemical Diversity of Biscembranoid Derivatives, Neutrophilic Inflammatory Mediators from the Cultured Soft Coral .

Biscembranoids are the distinctive tetraterpenoids owing a 14/6/14 membered tricyclic scaffold that have been mainly discovered in the soft corals, especially the genera , and . Recent findings have demonstrated the great anti-inflammatory potential of biscembranoid analogues in human neutrophils, motivating more chemical and biological explorations targeting these marine-derived natural products. In the current study, the chemical diversity of biscembranoids derived from the cultured-type von Marenzeller was illustrated through MS/MS molecular networking (MN) profiling approach.

Extract of Ficus septica modulates apoptosis and migration in human oral squamous cell carcinoma cells.

According to the alarming statistical analysis of global cancer, there are over 19 million new diagnoses and more than 10 million deaths each year. One such cancer is the oral squamous cell carcinoma (OSCC), which requires new therapeutic strategies. Ficus septica extract has been used in traditional medicine to treat infectious diseases.

Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential.

In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022.

Probing Anti-Leukemic Metabolites from Marine-Derived sp. LY1209.

The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of sp. LY1209 exhibited the most potent anti-proliferative effect against Molt 4 leukemia cells.

Scalarane-Type Sesterterpenoids from the Marine Sponge sp. Alleviate Inflammation in Human Neutrophils.

Sponge-derived scalaranes are remarkable sesterterpenoids previously found to exhibit profound inhibitory effects against neutrophilic inflammation. In our current work, we constructed the metabolomic profile of marine sponge sp. for the first time using a tandem mass spectrometry (MS/MS) molecular networking approach.

Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge sp.: Moving from Correlation toward Causation.

Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of sp.

The Configuration-Dependent Anti-Leukemic Effect of Manoalide Stereoisomers: Reignite Research Interest in these Sponge-Derived Sesterterpenoids.

Manoalide was studied as a potential anti-inflammatory agent for the last forty years and more than 200 publications and 180 patents were reported on this compound. However, the configurations at positions 24 and 25 and configuration-dependent bioactivity were not yet studied. In the current report, ten manoalide-like sesterterpenoids were isolated from Luffariella sp.

Isomalabaricane Triterpenes from the Marine Sponge sp.

The marine sponge of the genus , , , and are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H () and rhabdastin I ().

Natural Products from Octocorals of the Genus (Family Nephtheidae).

In this review, 170 natural substances, including steroid, diterpenoid, sesquiterpenoid, peptide, prostaglandin, base, chlorolipid, bicyclolactone, amide, piperazine, polyketide, glycerol, benzoic acid, glycyrrhetyl amino acid, hexitol, pentanoic acid, aminoethyl ester, octadecanone, alkaloid, and a 53-kD allergenic component from octocorals belonging to genus , were listed. Some of these compounds displayed potential bioactivities.

Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents.

Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge sp.

13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts.

13-Acetoxysarcocrassolide (13-AC), a marine cytotoxic product isolated from the alcyonacean coral , exhibited potent antitumor and immunostimulant effects as reported in previous studies. However, the 13-AC antitumor mechanism of action against oral cancer cells remains unclear. The activity of 13-AC against Ca9-22 cancer cells was determined using MTT assay, flow cytometric analysis, immunofluorescence, immunoprecipitation, Western blotting, and siRNA.

12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77.

12-Deacetyl-12--scalaradial, a scalarane sesterterpenoid from a marine sponge , has been reported to possess cytotoxic activity on HepG2, MCF-7, and HCT-116 cells. However, there is no research to indicate that 12-deacetyl-12--scalaradial exhibited anticancer effect on cervical cancer HeLa cells. The aim of this study was to investigate the anticancer activity of 12-deacetyl-12--scalaradial against HeLa cells and to explore the mechanism.

Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral (Briareidae).

Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (-), along with two known analogues, briaexcavatolide P () and briaexcavatin P (), were isolated from the octocoral . The structures of briaranes - were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.

Probing Anti-Proliferative 24-Homoscalaranes from a Sponge sp.

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A-D (- ), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (), felixin F (), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid () were isolated from the sponge sp. The structures of scalaranes - were elucidated on the basis of spectroscopic analysis. Scalaranes - were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that and dominated in the anti- proliferative activity of the extract.

Fragilides U-W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral .

Three new 11,20-epoxybriaranes-fragilides U-W (-), as well as two known metabolites, junceellonoid D () and junceellin (), were obtained from the octocoral . The structures of briaranes - were elucidated by spectroscopic methods and briaranes and displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7.

New 8-Hydroxybriaranes from the Gorgonian Coral (Ellisellidae).

Three new 8-hydroxybriaranes-fragilides R-T (-) were obtained from a sea whip gorgonian coral . The structures of briaranes - were elucidated by using spectroscopic methods, including 1D (H and C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T ( and ) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively.

New 1,4-Dienonesteroids from the Octocoral sp.

Two new steroids, dendronesterones D () and E (), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (), 5α,8α-epidioxy-24()- methylcholesta-6,22-dien-3β-ol (), and 5α,8α-epidioxy-24()-methylcholesta-6,9(11),22-trien-3β-ol (), were isolated from an octocoral sp. The structures of steroids and were elucidated by using spectroscopic methods and steroid was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.

New 11,20-Epoxybriaranes from the Gorgonian Coral (Ellisellidae).

Two new 11,20-epoxybriaranes, fragilides P () and Q (), as well as two known analogues, robustolide F () and juncin Z (), were obtained from the gorgonian coral . The structures, including the absolute configurations of briaranes and , were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane decreased the generation of superoxide anions by human neutrophils.

New Furanocembranoids from .

Three new furanocembranoids-briaviodiol F () and briaviotriols A () and B ()-along with a known analogue, briaviodiol A (), were obtained from a cultured-type octocoral . The structures of cembranoids ⁻ were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds and exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.

Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum.

Four new briarane diterpenoids, briaviolides K-N (-), have been obtained from the cultured-type octocoral . Using a spectroscopic approach, the structures of briaranes - were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.