Publications by authors named "Bo-Miao Zhang"
Article Synopsis
- This study focused on identifying key genes and metrics from genomic DNA sequencing to predict the effectiveness of neoadjuvant chemotherapy in rectal cancer patients.
- Researchers analyzed DNA from cancer tissues and plasma of 16 patients, looking at various gene variations to differentiate responses to chemotherapy.
- Key findings included that certain genes (like EGFR and HSP90AA1) were linked to better chemotherapy responses, and a predictive score for chemotherapy efficacy could be useful for patient prognosis.
Background: This study aimed to establish a novel quantification system of ferroptosis patterns and comprehensively analyze the relationship between ferroptosis score (FS) and the immune cell infiltration (ICI) characterization, tumor mutation burden (TMB), prognosis, and therapeutic sensitivity in left-sided and right-sided colon cancers (LCCs and RCCs, respectively).
Methods: We comprehensively evaluated the ferroptosis patterns in 444 LCCs and RCCs based on 59 ferroptosis-related genes (FRGs). The FS was constructed to quantify ferroptosis patterns by using principal component analysis algorithms.
Background: With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the development of CRC.
Methods: We examined expression levels of lncRNA CRNDE and miR-181a-5p in 64 cases of CRC tissues and cell lines by qRT-PCR.