Publications by authors named "Bo-Lun Jiang"
Article Synopsis
- FGFR3 has varying effects in different tipos of cancers, and its specific role in pancreatic ductal adenocarcinoma (PDAC) needs more clarity.
- Researchers used RNA interference to reduce FGFR3 levels in PDAC cell lines, confirming that its knockdown leads to decreased cell proliferation and changes in key cell cycle proteins.
- High levels of nuclear FGFR3 in tumor tissues were linked to advanced cancer stages and poor survival rates, and it was identified as an independent poor prognostic factor for patients post-surgery.
Objective: Thus far, expression, clinicopathologic, and prognostic implication of small mothers against decapentaplegic 7 (Smad7), matrix metalloproteinase 2 (MMP2), and matrix metalloproteinase 9 (MMP9) in pancreatic ductal adenocarcinoma (PDAC) were rarely investigated or controversial.
Methods: Expression of Smad7, MMP2, and MMP9 was detected using immunohistochemistry in tissue microarrays based on 322 patients with curatively resected PDAC. Their expression pattern, clinicopathologic, and prognostic relevance were further evaluated.
Intraductal oncocytic papillary neoplasm of the pancreas: A systematic review.
Pancreatology
September 2019
Background: Intraductal oncocytic papillary neoplasm of the pancreas (IOPN-P) is a rare subtype of intraductal papillary mucinous neoplasm (IPMN). This study was performed to summarize the clinicopathological features and management of IOPN-P.
Methods: English-language articles were searched from MEDLINE and EMBASE from the first report of IOPN-P in 1996 until 1 May 2019 following the methodology in the PRISMA guidelines.