Construction of Axially Chiral 4-Aminoquinolines by Cycloaddition and Central-to-Axial Chirality Conversion.

A two-step strategy has been established for the enantioselective synthesis of 4-aminoquinolines possessing axial chirality. This approach involves a chiral phosphoric acid-catalyzed cycloaddition, followed by a DDQ oxidation step. The method offers efficient access to a variety of 1,1'-biaryl-2,2'-amino alcohol derivatives in excellent yields and enantioselectivities (up to 98% yield and 93% ee).

Trend of unplanned reoperation rates after lumbar degenerative surgery from 2011 to 2019: a large patient population study.

Background: Unplanned reoperation is commonly performed due to postoperative complications. Previous studies have reported the incidence of unplanned reoperation following lumbar spinal surgery. But few study focused on the trend of reoperation rates, and the reasons of unplanned reoperation were not clear.

A practical dynamic nomogram model for predicting bone metastasis in patients with thyroid cancer.

Purpose: The aim of this study was to established a dynamic nomogram for assessing the risk of bone metastasis in patients with thyroid cancer (TC) and assist physicians to make accurate clinical decisions.

Methods: The clinical data of patients with TC admitted to the First Affiliated hospital of Nanchang University from January 2006 to November 2016 were included in this study. Demographic and clinicopathological parameters of all patients at primary diagnosis were analyzed.

Short-segment fixation and transpedicular bone grafting for the treatment of thoracolumbar spine fracture.

Purpose: Thoracolumbar fracture is one of the most common fractures of spine. And short-segment posterior fixation including the fractured vertebra (SSPFI) is usually used for the surgical treatment of it. However, the outcomes of SSPFI for different types of thoracolumbar fractures are not clear, and whether it is necessary to perform transpedicular bone grafting is still controversial.

LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.

Background: Osteosarcoma (OS) is one of the malignant bone tumors with strong aggressiveness and poor prognosis. Leucine-rich repeats and immunoglobulin-like domains2 (LRIG2) is closely associated with the poor prognosis of a variety of tumors, but the role of LRIG2 in osteosarcoma and the underlying molecular mechanism remains unclear.

Objective: The aim of this study was to determine the function of LRIG2 in OS and the related molecular mechanism on cell proliferation, apoptosis and migration of OS.

Using Machine Learning Methods to Predict Bone Metastases in Breast Infiltrating Ductal Carcinoma Patients.

Breast cancer (BC) was the most common malignant tumor in women, and breast infiltrating ductal carcinoma (IDC) accounted for about 80% of all BC cases. BC patients who had bone metastases (BM) were more likely to have poor prognosis and bad quality of life, and earlier attention to patients at a high risk of BM was important. This study aimed to develop a predictive model based on machine learning to predict risk of BM in patients with IDC.

Using Preoperative and Intraoperative Factors to Predict the Risk of Surgical Site Infections After Lumbar Spinal Surgery: A Machine Learning-Based Study.

Objective: To develop a model based on machine learning to predict surgical site infection (SSI) risk in patients after lumbar spinal surgery (LSS).

Methods: Patients who developed postoperative SSI after LSS in the First Affiliated Hospital of Nanchang University between December 2010 and December 2019 were retrospectively reviewed. Preoperative and intraoperative variables, including age, diabetes mellitus, hypertension, body mass index, previous spinal surgery history, surgical duration, number of fused segments, blood loss, and surgical procedure were analyzed.

Downregulation of miR-124 predicts poor prognosis in pancreatic ductal adenocarcinoma patients.

Background And Aims: miRNA-124 (miR-124) expression was known to be downregulated in patients with pancreatic ductal adenocarcinoma (PDAC). Downregulation of miR-124 was significantly associated with poor prognosis in patients with PDAC. Recent studies have shown that circulating miRNAs could be the potential biomarkers for invasive diagnostic as well as prognostic purposes.

[Effects of landscape heterogeneity on the availability of amphibians' habitats in agricultural region on the lower reaches of the Yellow River, China.].

SelectingFengqiu County in Henan Province, a typical region of the lower Yellow River, as the study area, adopting the analysis method of graph theory, with the support of geographic information systems (GIS) and R software, we analyzed the effects of landscape composition and landscape configuration, the mean pond size (MS), the number of ponds (NP), and distance to the nearest roads (DR), on habitat availability of amphibian species under different levels of dispersal ability (250, 500, 1000 and 2000 m), by referring the probability index of connectivity (PC) and the important value of patches (percentage of the variation in PC, dPC) to the degree of availability of ponds for amphibians' breeding. The results indicated that the ponds availability for amphibians' breeding was closely related to MS, NP, and DR. Therein, MS and NP were the key factors determining the availability of ponds under the dispersal ability of 250 m, and then MS and DR were the most significant influencing factors on pond availability under the dispersal ability of 500 m.

Microwave Ablation: The Differences Between Biliary Cirrhosis and Normal Porcine Liver Using a Cooled-tip Electrode.

Aim: To elucidate the difference in both in vivo and ex vivo microwave ablation in a biliary cirrhotic porcine liver model using a cooled-tip electrode.

Materials And Methods: Microwave ablation with cooled-tip electrode was conducted under laparotomy. Morphological and pathological characteristics of the ablated areas were compared.