Publications by authors named "Bo-Jian Fei"
Objectives: This study aims to evaluate diagnostic performance of radiomic analysis using computed tomography (CT) to identify lymphovascular invasion (LVI) in patients diagnosed with rectal cancer and assess diagnostic performance of different lesion segmentations.
Methods: The study is applied to 169 pre-treatment CT images and the clinical features of patients with rectal cancer. Radiomic features are extracted from two different volumes of interest (VOIs) namely, gross tumor volume and peri-tumor tissue volume.
Article Synopsis
- AMPD2 is an enzyme that influences energy supply and metabolism in smooth muscle, and its role in colorectal cancer (CRC) has not been well understood until now.
- Research showed that AMPD2 is significantly overexpressed in CRC tissues compared to normal tissues, and its expression is linked to the Notch signaling pathway, which is crucial for cancer progression.
- High levels of AMPD2 in CRC are associated with more advanced tumors and poorer patient outcomes, suggesting that it could serve as a new prognostic biomarker for CRC.
Aim: To investigate the role of activating transcription factor 4 (ATF4) in glucose deprivation (GD) induced colorectal cancer (CRC) drug resistance and the mechanism involved.
Methods: Chemosensitivity and apoptosis were measured under the GD condition. Inhibition of ATF4 using short hairpin RNA in CRC cells under the GD condition and in ATF4-overexpressing CRC cells was performed to identify the role of ATF4 in the GD induced chemoresistance.
[Significance and expression of p53, p21(Cip1/WAF1) and Gadd45α in breast neoplasm tissues].
Zhonghua Yi Xue Za Zhi
September 2012
Objective: To explore the expression and significance of p53, p21(Cip1/WAF1) and Gadd45α protein in breast cancer and their correlations with clinicopathologic features and prognosis in breast cancer.
Methods: The expressions of p53, p21(Cip1/WAF1) and Gadd45α proteins were determined by immunohistochemical staining. The relationship between these three proteins and clinicopathologic features in breast cancer was analyzed by χ(2) test and Spearman's rank correlation analysis.