Metabolomic Comparison of Guava ( L.) Leaf Extracts Fermented by and and Their Antioxidant and Antiglycation Activities.

Probiotic fermentation of plant-based materials can lead to the generation of various bioactive substances via bacterial metabolites and the biotransformation of phenolic compounds. We compared the metabolic differences between fermentation by KCTC15072BP (LFG) and fermentation by KGMB00831 (LPG) in guava leaf extract (0%, 0.5%, and 2% (/))-supplemented medium via non-targeted metabolite profiling.

α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells.

Ethnopharmacological Relevance: The rhizomes of Cyperus rotundus (Cyperaceae) have been used in Asian traditional medicine for the treatment of several inflammatory diseases. However, the anti-inflammatory effects of α-cyperone, a major active compound of Cyperus rotundus, are poorly understood.

Materials And Methods: PGE2 and cytokines released from cells were measured using an EIA assay kit.