5--Sinuleptolide from Soft Corals of the Genus Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity.

Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5--Sinuleptolide, a norditerpene isolated from sp., has been demonstrated to possess cytotoxic activity against cancer cells.