Publications by authors named "Bo-Chuan Liu"
Unlabelled: The efficacy of the G-protein is influenced by N-linked glycosylation, which serves as the sole immunogen of the rabies virus vaccine. However, achieving satisfactory immune-protection efficacy remains challenging, owing to the heterogeneous glycosylation of G-proteins. Within molecular dynamics, examining the impact of N-glycan heterogeneity on the structural characteristics of G-proteins provides insights into the relationship between antigens and the efficacy of rabies virus vaccines.
View Article and Find Full Text PDFInhibition of PTPN21 has antitumor effects in glioma by restraining the EGFR/PI3K/AKT pathway.
Toxicol Appl Pharmacol
September 2022
Article Synopsis
- - The study explores the role of Protein tyrosine phosphatase non-receptor type 21 (PTPN21) in glioma, finding it is up-regulated in glioma tissues and linked to poor survival rates for patients.
- - Silencing PTPN21 in glioma cells leads to significant anticancer effects, such as inhibiting cell growth, blocking metastasis, and increasing sensitivity to chemotherapy.
- - Mechanistically, PTPN21 affects the EGFR/PI3K/AKT signaling pathway, and its silencing disrupts tumor growth in vivo, highlighting its potential as a target for glioma treatment.
Background: Neurocutaneous melanosis (NCM) is a rare congenital, nonhereditary neurocutaneous syndrome that mainly occurs in children; adult NCM is very rare. Due to its rarity, the clinical features and treatment strategies for NCM remain unclear. The purpose of this study was to explore the clinical features, diagnosis, treatment and prognosis of NCM in adults.
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