Publications by authors named "Bo Young Yoon"

Article Synopsis
  • The Dr. LEE Jong-wook Fellowship Program aims to improve healthcare in partner countries and developed new performance evaluation indicators to measure long-term educational impacts.
  • A three-stage method involved reviewing existing evaluation models, validating criteria through expert surveys, and applying the analytic hierarchy process to determine the importance of each indicator.
  • The resulting evaluation framework includes 4 areas, 20 items, and 92 indicators, providing a comprehensive tool for assessing the program's effectiveness and enhancing international healthcare collaboration.
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  • Researchers wanted to see if simple lab tests could help choose between two medications, tocilizumab (TCZ) and tumor necrosis factor inhibitors (TNFi), for patients with rheumatoid arthritis (RA).
  • They looked at data from almost 900 RA patients who started treatment with either TCZ or TNFi between 2013 and 2021.
  • The results showed that patients taking TCZ were less likely to stop their medication compared to those on TNFi, especially if they had anemia (low red blood cells).
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Purpose: The coronavirus disease 2019 pandemic saw many restrictions on the provision of emergency medical service (EMS) training through actual field trips (AFTs), requiring a search for alternatives. This study aimed to assess trainees' reactions to virtual field trips (VFTs) and determine the characteristics of instructional design for successful VFTs using edited videos and expert interviews.

Methods: This study evaluated Uzbekistan trainees' reactions to the VFT of EMS training using questionnaires in three categories: satisfaction, relevance, and engagement.

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  • This study explores how medical schools in Korea adapted their academic affairs and student support during the COVID-19 pandemic and their future plans for education delivery.
  • An online survey of 40 medical schools yielded responses from 33 schools and 1,342 students, focusing on instructional methods and student experiences with remote learning.
  • Findings indicate a significant shift to online learning, with many schools considering a hybrid model post-pandemic, while students appreciated the flexibility online classes provide despite lower participation scores.
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Background: Patient-centered outcomes can be achieved when common core and specialist competencies are achieved in a balanced manner. This study was conducted to assess the need to fill the gap between the defined competencies and learners' achievement, in order to improve the internal medicine (IM) training education curriculum for promoting patient-centered outcomes.

Methods: A cross-sectional online survey was conducted.

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Background/aims: We aimed to compare the effectiveness and safety of Janus kinase inhibitors (JAKi) vs. biologic disease- modifying antirheumatic drugs (bDMARD) in Korean patients with rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic DMARDs.

Methods: A quasi-experimental, multi-center, prospective, non-randomized study was conducted to compare response rates between JAKi and bDMARDs in patients with RA naïve to targeted therapy.

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  • * This study focused on understanding the structure and behavior of the MLC1 protein, revealing it has eight transmembrane (TM) domains with both ends facing the cytoplasm.
  • * The researchers discovered that MLC1 can form oligomers, specifically trimeric complexes, and the findings set the stage for detailed structural and functional studies of the protein.
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Osteoarthritis (OA) has a multifactorial etiology that includes oxidative stress. Oxidative balance score (OBS) is a well-known indicator of oxidative stress. However, the association between OBS and OA has not been assessed.

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Purpose: This study aimed to explore students' cognitive patterns while solving clinical problems in three different types of assessments - clinical performance examination (CPX), multimedia case-based assessment (CBA), and modified essay question (MEQ) - and thus, to understand how different types of assessments can afford different thinking.

Methods: A total of six test-performance cases from two fourth-year medical students were used for a cross-case study. Data were collected through one-on-one interviews using a stimulated recall protocol where students were: 1) shown videos of themselves taking each assessment and 2) asked to elaborate on what they were thinking.

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Aim: Despite high clinical disease activity, some patients with active rheumatoid arthritis (RA) have normal acute phase reactant (APR) values. This study aimed to determine the clinical outcomes of active RA patients with normal APR values.

Method: Of 5376 patients with RA enrolled in the Korean observational study network for arthritis (KORONA) registry, 400 patients with disease duration of <2 years who had Clinical Disease Activity Index (CDAI) score of >2.

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Article Synopsis
  • The study aimed to analyze the characteristics of rheumatoid arthritis (RA) patients in Korea who have been treated with DMARDs for over 6 months, focusing on identifying factors linked to poor health outcomes.
  • A total of 2000 RA patients over 20 years old participated in a cross-sectional study, where health quality was assessed using EQ-5D and functional disability via KHAQ; both univariate and multivariate analyses were performed to evaluate the results.
  • Findings revealed that older age, female gender, and higher Disease Activity Scores (DAS) correlated with worse health-related quality of life and functional disability, emphasizing the need for tailored treatment strategies based on DAS in the early management of RA.
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Background/aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA).

Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis > 1 year).

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  • This study investigated the difference between how Korean patients with rheumatoid arthritis (RA) perceive their cognitive dysfunction and their actual performance on computerized cognitive tests.
  • Researchers assessed 40 participants' subjective cognitive impairment using the Perceived Deficits Questionnaire and evaluated objective cognitive function through 6 computerized tests.
  • The results showed no significant link between subjective and objective cognitive scores, highlighting the importance of psychological factors like depression and sleep quality in understanding cognitive complaints in RA patients.*
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To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities.

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Purpose: Hypothetico-deductive reasoning (HDR) is an essential learning activity and a learning outcome in problem-based learning (PBL). It is important for medical students to engage in the HDR process through argumentation during their small group discussions in PBL. This study aimed to analyze the quality of preclinical medical students' argumentation according to each phase of HDR in PBL.

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Objective: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs.

Methods: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs.

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Remission is a primary end point of in clinical practice and trials of treatments for rheumatoid arthritis (RA). The 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria were developed to provide a consensus definition of remission. This study aimed to assess the concordance between the new remission criteria and the physician's clinical judgment of remission and also to identify factors that affect the discordance between these two approaches.

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Background/aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients.

Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of ≤ 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group.

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Objective: To identify the level of agreement between patients with rheumatoid arthritis (RA) and physicians in the global assessment of disease activity and to explore factors influencing their discordance.

Methods: A total of 4368 patients with RA were analyzed from the KORean Observational study Network for Arthritis (KORONA) database. Patients were divided into four subgroups according to difference from their physicians in the assessment of disease activity by substracting physician's visual analog scale (VAS) from patient's VAS as follows: positive discordance group I (10 mm ≤ discordance <25 mm), positive discordance group II (≥25 mm), concordance (<|10| mm), and negative discordance (≤ -10mm).

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Purpose: The quality of problem representation is critical for developing students' problem-solving abilities in problem-based learning (PBL). This study investigates preclinical students' experience with standardized patients (SPs) as a problem representation method compared to using video cases in PBL.

Methods: A cohort of 99 second-year preclinical students from Inje University College of Medicine (IUCM) responded to a Likert scale questionnaire on their learning experiences after they had experienced both video cases and SPs in PBL.

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Article Synopsis
  • The study aimed to explore the prevalence of osteoporosis in postmenopausal women with rheumatoid arthritis (RA) using the KORONA database.
  • Among 1,322 patients, nearly 47% were found to have osteoporosis, with a higher history of fractures in this group, particularly of the femur and wrist.
  • Multiple risk factors for osteoporosis were identified, including older age, low body mass index, longer RA duration, and higher glucocorticoid use, although BMD measurement rates in these patients were still considered low despite their high fracture risk.
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  • The study aimed to develop a mapping model to estimate EQ-5D utility values for rheumatoid arthritis (RA) patients in Korea using various health assessment tools.
  • Data from 3,557 RA patients were analyzed, and multiple statistical methods (OLS, Tobit, two-part model) were used to create and validate the model.
  • The best model incorporated HAQ-DI, pain VAS, and DAS28, demonstrating superior predictive accuracy with a specific mapping equation that allows estimation of EQ-5D values even when direct measurements are absent.
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The aim of this study was to compare anti-tumor necrosis factor-α (TNFα) treatment status in rheumatoid arthritis (RA) patients with the Korean National Health Insurance (KNHI) reimbursement eligibility criteria and with American College of Rheumatology (ACR) recommendations, Japan College of Rheumatology (JCR) guidelines and British Society for Rheumatology (BSR) guidelines. Between December 2011 and August 2012, outpatients from 17 South Korean general hospitals diagnosed with RA according to the 1987 ACR criteria were enrolled into a noninterventional, cross-sectional, observational study. Of 1700 patients (1414 female (83.

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Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease that is often painful and debilitating. Patients with RA are increasingly receiving complementary and alternative medicine (CAM). We aimed to identify the patient characteristics and disease-specific factors associated with Korean patients with RA who decide to start treatment with CAM.

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  • Pulmonary arterial hypertension (PAH) is a serious condition affecting patients with connective tissue diseases (CTD), and a study analyzed the survival rates and factors affecting mortality among Korean patients with CTD-PH over a follow-up period of around 3.8 years.
  • The study included 174 patients, with findings showing a 1-year survival rate of 90.7% and a 3-year survival rate of 87.3%, highlighting that those with rheumatoid arthritis had the lowest survival rates.
  • Key negative prognostic factors included low diffusion capacity of carbon monoxide (DLCO), pleural effusion, and diabetes, while the presence of anti-UI-RNP antibodies was found to have a protective effect; also, using
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