Diverse Structures Based on a Heptanuclear Cobalt Cluster with 0D to 3D Metal-Organic Frameworks: Magnetism and Application in Batteries.

Polymetallic complexes with interesting multifunctions have attracted extensive investigation. Synthesized through the use of different cobalt salt anions and solvents, five complexes, namely [Co Co (H L) Cl (MeOH)] (1), [Co Co (H L) (CH COO) (HCOO)⋅H O] (2), [Co Co (H L) (HCOO) (NO )⋅2H O] (3), [Co Co (H L) (bda)(CH COO) ⋅2H O] (4), and [Co Co (H L) (ipa)(HCOO) (dmf)⋅H O] (5) (H L=bis-tris propane; BDA=biphenyl-4,4'-dicarboxylic acid; IPA=isophthalic acid; DMF=N,N-dimethylformamide), based on the heptanuclear {Co Co } cluster with structures from 0D to 3D metal-organic frameworks (MOFs) have been solvothermally synthesized. Compound 1 is the first 0D heptanuclear cluster based on H L.

One-pot synthesis of 7,9-dialkylpurin-8-one analogues: broad substrate scope.

The one-pot and direct synthesis of 7,9-dialkylpurin-8-one analogues with broad substrate scope has been developed. This copper-catalyzed C-H oxidation reaction could avoid multistep synthesis of quaternary ammonium salts and expand the scope of halogenated alkanes. Moreover, benzimidazole derivatives are also applicable in the catalytic system.

Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells.

Background & Objective: Cerebral hypoxia is known to be involved in many neurodegenerative diseases such as Alzheimer's and cerebrovascular dementia. The present study was designed to investigate the effects of flavonoids from aerial part of Scutellaria baicalensis Georgi (SSF) on potassium cyanide (KCN) -induced hypoxic cytotoxicity in rat pheochromocytoma cell line PC12, and to understand the probable mechanism.

Methods: The rat pheochromocytoma cell line PC12 was subjected to hypoxia by 200 microM KCN for 30 min.

Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells.

Reactive oxygen species (ROS) are important mediators in a number of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). The neuroprotective effects of flavonoids from the stems and leaves of Scutellaria baicalensis Georgi (SSF) against hydrogen peroxide (H2O2)-induced rat pheochromocytoma line PC12 injury were evaluated by cell lesion, free radicals and ATPase disorders. Following a 30 min exposure of the cells to H2O2 (100 microm), a marked decrease in cell survival and activity of superoxide dismutase (SOD) and Na+-K+-ATPase as well as an increase of malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release were observed.