Systematic degradation process of petroleum hydrocarbons by an integrated bacterial consortium under bottom seawater and surface seawater environments.

Dealing with oil spills is urgent, and bioaugmentation is a low-cost and environmentally friendly method. However, little research has been done on the remediation effect of bioaugmentation in oil-polluted environments with bottom seawater microorganisms. This work constructed the bottom seawater (S) group and surface seawater environment (T) group to study the oil degradation ability and the microbial community successions tendency with the function of integrated bacterial consortium.

Neoadjuvant therapy with triple therapy for centrally located hepatocellular carcinoma.

Background: Centrally located hepatocellular carcinoma (HCC) is a subtype HCC with special location adjoined hepatic portals. It is difficult to be radically resected with sufficient surgical margin. We discussed whether neoadjuvant therapy could increase surgical margin and reduce recurrence.

Biomagnetic monitoring of urban atmospheric pollution: A review of magnetic signatures from different types of plants.

Biomagnetic monitoring has rapidly emerged as a valuable tool in urban atmospheric pollution (UAP) assessment due to its high spatial resolution, complementing traditional monitoring systems. This review systematically elucidates the principles of plant dust retention and the factors influencing it, while also reviewing the advancements in global research on UAP monitoring through the magnetic properties of various plant species. We provide a comprehensive analysis of the current applications of biomagnetic monitoring in UAP and identify critical challenges, including species-specific monitoring discrepancies, complex pollution sources, and non-standardized sample preparation methods.

Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance.

Selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitors not only exhibit antitumor efficacy but also offer the potential to mitigate the toxicities typically associated with broader PARP inhibition. In this study, we designed and synthesized a series of small molecules targeting highly selective PARP1 inhibitors. Among these, demonstrated excellent selectivity to PARP1 along with the capability to effectively cross the blood-brain barrier (BBB).

Comparative transcriptome analysis and heterologous overexpression indicate that the ZjZOG gene may positively regulate the size of jujube fruit.

Background: Fruit size is a crucial economic trait that impacts the quality of jujube (Ziziphus jujuba), however, research in this area remains limited. This study utilized two jujube cultivars with similar genetic backgrounds but differing fruit sizes to investigate the regulatory mechanisms affecting fruit size through cytological observations, transcriptome sequencing, and heterologous overexpression.

Results: The findings reveal that variations in mesocarp cell numbers during early fruit development significantly influence final fruit size.

Cardiac cement embolism and asymptomatic pulmonary embolism caused by percutaneous vertebroplasty for osteoporotic vertebral fracture: a case report.

Background: As society ages, the incidence of osteoporotic vertebral compression fractures steadily rises. Procedures like percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP) have proven effective in significantly relieving pain in patients with these fractures. While PKP and PVP are minimally invasive, complications can still occur.

Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3.

Background: Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancers. Cisplatin (DDP)-based combination chemotherapy is the main treatment of NSCLC. Due to resistance to DDP, 5-year overall survival rate of NSCLC patients is very low.

Determination of neutron spectrum based on artificial neural network using liquid scintillation detector EJ-301.

This paper focuses on the neutron spectrum measurement using a liquid scintillation detector, where the neutron spectrum could be identified and unfolded from the light output distribution of the EJ-301 liquid scintillation detector through a linear artificial neural network (ANN). The response functions of the EJ-301 detector for monoenergetic neutron sources, as well as the light outputs, have been simulated and calculated by Monte Carlo procedure FLUKA. The linear ANN was trained and tested through the simulated data, where response functions were set as the input of ANN and the corresponding neutron spectra were output.

Upregulation of HSD11B1 promotes cortisol production and inhibits NK cell activation in pancreatic adenocarcinoma.

Cortisol is a glucocorticoid hormone that has immunosuppressive function. Elevated basal cortisol levels are present in patients with some kinds of cancers, but its role in the microenvironment of pancreatic adenocarcinoma (PAAD) remains unclear. This study analyzed the expression of genes involved in cortisol generation by using high-throughput sequencing data from TCGA portal and found HSD11B1 was significantly upregulated in patients with PAAD.

Ailanthone Increases Cisplatin-induced Apoptosis and Autophagy in Cisplatin Resistance Non-small Cell Lung Cancer Cells through the PI3K/AKT/mTOR Pathway.

Introduction: The effectiveness of therapy is strongly impacted by the resistance of lung cancer cells to cisplatin. The objective of this research is to characterize the impact of ailanthone on cisplatin resistance in non-small cell lung cancer (NSCLC) and examine any potential in vivo and in vitro molecular pathways.

Methods: Following treatment of A549/DDP cells with ailanthone and cisplatin, cell survival and apoptosis were measured using flow cytometry and Cell Counting Kit-8 (CCK- 8) assays, respectively.

Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1-benzo[]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.

Herein, we described the rational drug design and synthesis of a series of 5-amino-4-fluoro-1-benzo[]imidazole-6-carboxamide derivatives that inhibit MEK and RAF kinases. The detailed screening cascades revealed that was a preferred compound, which might act like a "clamp" to stabilize the MEK/RAF complex, thereby effectively inhibiting MEK1, BRAF, and BRAF with IC values of 28, 3, and 3 nM, respectively. possessed an excellent selectivity over other 312 human-related kinases at 1 μM.

A Telemedicine Analytic Framework for Fully and Semi-automatic Alzheimer's Disease Screening using Clock Drawing Test.

More than 6 million Americans are at risk for Alzheimer's Disease Related Dementias (ADRD), most of whom are 65 or older. The clock drawing test (CDT) is a quick, simple, and effective technique that has the potential advantage of self-management and screening for ADRD patients. Current CDT-based ADRD screening studies focus more on efficacy, involving many handcrafted features, ignoring data modalities, and lacking validation.

Volatile Profile Characterization of Jujube Fruit via HS-SPME-GC/MS and Sensory Evaluation.

Current research does not fully elucidate the key compounds and their mechanisms that define the aroma profile of fresh jujube fruits. Therefore, this study conducted a comprehensive analysis of both free and glycosidically bound aroma compounds in fresh jujube fruits of ten cultivars. Utilizing gas chromatography-mass spectrometry (GC-MS), we identified 76 volatile free aroma compounds and 19 glycosidically bound volatile compounds, with esters, aldehydes, and ketones emerging as the predominant volatile compounds in the jujube fruits.

Strategies and Recent Advances on Improving Efficient Antitumor of Lenvatinib Based on Nanoparticle Delivery System.

Lenvatinib (LVN) is a potentially effective multiple-targeted receptor tyrosine kinase inhibitor approved for treating hepatocellular carcinoma, metastatic renal cell carcinoma and thyroid cancer. Nonetheless, poor pharmacokinetic properties including poor water solubility and rapid metabolic, complex tumor microenvironment, and drug resistance have impeded its satisfactory therapeutic efficacy. This article comprehensively reviews the uses of nanotechnology in LVN to improve antitumor effects.

Progress and application of lung-on-a-chip for lung cancer.

Lung cancer is a malignant tumour with the highest incidence and mortality worldwide. Clinically effective therapy strategies are underutilized owing to the lack of efficient models for evaluating drug response. One of the main reasons for failure of anticancer drug therapy is development of drug resistance.

Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.

Aim: To reveal the contribution of Irisin in the beneficial effects of resistance exercise on myocardial fibrosis (MF) and cardiac function in the mice with myocardial infarction (MI).

Methods: The MI model was built by ligating the left anterior descending coronary artery in Fndc5 knockout mice (Fndc5). Resistance exercise was started one week after surgery and continued for four weeks.

Beyond person-environment congruence: Career adaptability, career personality styles, and thinking styles.

The main objectives of this study were to explore the relationship between career personality styles and career adaptability and the role of thinking styles in such relationship. Eight hundred and eleven Chinese students, who were trained as pre-service kindergarten teachers, responded to the Career Personality Styles Inventory, the shortened Thinking Styles Inventory-Revised, and the Career Adapt-Ability Scale - Short Form. Results suggested that the career personality styles (i.

Identification of Key Genes of Fruit Shape Variation in Jujube with Integrating Elliptic Fourier Descriptors and Transcriptome.

Jujube () exhibits a rich diversity in fruit shape, with natural occurrences of gourd-like, flattened, and other special shapes. Despite the ongoing research into fruit shape, studies integrating elliptical Fourier descriptors (EFDs) with both Short Time-series Expression Miner (STEM) and weighted gene co-expression network analysis (WGCNA) for gene discovery remain scarce. In this study, six cultivars of jujube fruits with distinct shapes were selected, and samples were collected from the fruit set period to the white mature stage across five time points for shape analysis and transcriptome studies.

Transcriptome profiles reveal response mechanisms and key role of PsNAC1 in Pinus sylvestris var. mongolica to drought stress.

Background: Drought stress severely impedes plant growth, and only a limited number of species exhibit long-term resistance to such conditions. Pinus sylvestris var. mongolica, a dominant tree species in arid and semi-arid regions of China, exhibits strong drought resistance and plays a crucial role in the local ecosystem.

[Analysis and Evaluation of Heavy Metal Pollution in Farmland Soil in China：A Meta-analysis].

In this study, a Meta-analysis was used to investigate the pollution status of eight farmland soil heavy metal elements (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in China. Meanwhile, their spatiotemporal changes and differences between different types of cultivated land were explored. The research data were chosen from 449 relevant literature data collected by CNKI and Web of Science from 2005 to 2021, and the Meta-analysis used a weighted method based on "sampling numbers", "study area", and "standard deviation".

Advances in superhydrophobic material research: from preparation to electrified railway protection.

Freezing is a serious problem that affects the power, transport, and transmission industries and is a major concern for the national economy and safety. Currently, several engineering de-icing methods, such as thermal, mechanical, and chemical de-icing, have shown problems related to energy consumption, efficiency, and the environment. Superhydrophobic materials have high droplet contact and roll angles, which can reduce the droplet residence and ice adhesion on their surfaces and have unique advantages in the self-cleaning and anti-icing fields.

Choriocapillaris flow features in children with myopic anisometropia.

Aims: To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia.

Methods: In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA).