Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells.

5-Fluorouracil (5-FU) is commonly used to treat breast cancer; however, it becomes increasingly ineffective with tumor progression. Epithelial-to-mesenchymal transition (EMT) is a process whereby cells acquire morphologic and molecular alterations facilitating tumor metastasis and progression. Emerging evidence associates chemoresistance with acquisition of EMT in cancer.

[Inhibiting effect of Shuang-huang-lian microemulsion on cytokines of carrageenan induced pleuritis in rats].

Objective: To explore the anti-inflammatory effect and possible mechanism of Shuang-huang-lian (SHL) microemulsion.

Method: Rat model of pleuritis was established by thoracic injecting 0.2 mL of 1% carrageenan.