Publications by authors named "Bo Ning"

Spatial omics methods are extensions of traditional histological methods that can illuminate important biomedical mechanisms of physiology and disease by examining the distribution of biomolecules, including nucleic acids, proteins, lipids, and metabolites, at microscale resolution within tissues or individual cells. Since, for some applications, the desired resolution for spatial omics approaches the nanometer scale, classical tools have inherent limitations when applied to spatial omics analyses, and they can measure only a limited number of targets. Nanotechnology applications have been instrumental in overcoming these bottlenecks.

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  • - The study investigates how SARS-CoV-2 monoclonal antibody (mAB) therapy affects the immune response in five cancer patients infected with the virus, comparing them to non-mAB-treated controls.
  • - Blood samples were analyzed for various immune responses, revealing that all patients produced antibodies and T-cell responses similar to those of controls, despite some having B-cell deficiencies.
  • - The findings indicate that mAB therapy results in a robust immune response against SARS-CoV-2 in cancer patients, showing the potential for effective protective immunity even with underlying malignancies.
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Developing social-emotional skills is crucial for all children and adolescents, particularly those experiencing social and emotional difficulties. This study used network analysis to identify the central skills and network association of different social-emotional skills and investigated how these networks differ between childhood and adolescence. Data were obtained from the 2019 Survey on Social and Emotional Skills by the Organization for Economic Co-operation and Development.

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Purpose: The purpose of this study is to retrospectively analyze children treated conservatively in our hospital to explore the clinical characteristics of children with traumatic atlantoaxial joint infra-anterior dislocation complicating odontoid fracture and the therapeutic effects of treatment.

Methods: Patients with atlantoaxial joint infra-anterior dislocation complicating odontoid fracture received conservative treatment, which comprised three steps: cervical traction (2 weeks), plaster fixation (2 months), and brace fixation (3 months).

Results: We treated three patients (boy:girl = 0:3, mean age = 2.

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  • * A randomized trial in China involved 269 patients who were assigned to start antiplatelet therapy early (3 days post-surgery) or late (30 days post-surgery) to evaluate safety and effectiveness on major cardiovascular events.
  • * The study, which involved patients mostly around 60 years old, aimed to measure occurrences of new major ischaemic events and intracranial bleeding within 90 days after surgery, and is officially registered under ClinicalTrials.gov number NCT04820972.
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Aims: Congenital pseudarthrosis of the tibia (CPT) has traditionally been a difficult condition to treat, with high complication rates, including nonunion, refractures, malalignment, and leg length discrepancy. Surgical approaches to treatment of CPT include intramedullary rodding, external fixation, combined intramedullary rodding and external fixation, vascularized fibular graft, and most recently cross-union. The current study aims to compare the outcomes and complication rates of cross-union versus other surgical approaches as an index surgery for the management of CPT.

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  • Coronary heart disease (CHD) alongside anxiety or depression is gaining attention in cardiology, highlighting the need to understand their interconnected mechanisms.
  • Research indicates that Silent Information Regulatory Factor 1 (SIRT1) may be a key biomarker and therapeutic target, aiding in the treatment of CHD in patients also experiencing anxiety or depression.
  • This review explores SIRT1's structure, function, and mechanisms, detailing its role in reducing inflammation, oxidative stress, and enhancing protective effects in both cardiovascular and nervous systems.
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  • The study aimed to assess the effectiveness of Cross-Union surgery in treating tibial pseudarthrosis in children with neurofibromatosis type 1 (NF1).
  • Eight patients, aged between 1.8 and 13.3 years, had their clinical data analyzed for outcomes such as bone healing and any recurrence of fractures after surgery.
  • Results indicated an overall healing rate of 87.5% with no new fractures during follow-up, though some patients did experience minor leg length discrepancies and persistent ankle valgus.
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This study aims to investigate the mechanism of Xuanbai Chengqi Decoction in treating acute lung injury(ALI) based on network pharmacology and animal experiments. The potential targets and signaling pathways of Xuanbai Chengqi Decoction in regulating ALI were predicted by network pharmacology. The rat model of ALI was constructed and administrated with different doses of Xuanbai Chengqi Decoction.

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Background: The COVID-19 outbreak has profoundly affected the psychological well-being of university students globally. Previous studies have found a positive longitudinal link between fear of COVID-19 (FoC-19) and internet addiction. However, there is a notable gap in the literature regarding COVID-19-specific predictors and underlying mechanisms of internet gaming addiction (IGA).

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Purpose: The objective of this study was to evaluate the Masada and Jo classifications for clinical use in patients with forearm deformity caused by hereditary multiple osteochondroma and propose a new classification system that is all-inclusive and can guide clinical management.

Methods: A retrospective review of 275 forearms was performed. A split-sample approach was used, where 138 forearms were analyzed to create a new classification, which was then validated on the remaining 137 forearms.

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Aims: Given the possible radiation damage and inaccuracy of radiological investigations, particularly in children, ultrasound and superb microvascular imaging (SMI) may offer alternative methods of evaluating new bone formation when limb lengthening is undertaken in paediatric patients. The aim of this study was to assess the use of ultrasound combined with SMI in monitoring new bone formation during limb lengthening in children.

Methods: In this retrospective cohort study, ultrasound and radiograph examinations were performed every two weeks in 30 paediatric patients undergoing limb lengthening.

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  • - The sphincter of Oddi is a crucial muscle at the point where the biliary and pancreatic systems meet the small intestine, and dysfunction can lead to issues like pain and pancreatitis.
  • - Recent studies, particularly the EPISOD trial and the Rome IV consensus, have led to significant updates in how Sphincter of Oddi Dysfunction (SOD) is managed clinically.
  • - There is still controversy surrounding the treatment of type II SOD, especially in finding effective non-invasive options for patients who don't benefit from endoscopic treatments.
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Microbial composition plays an important role in the quality and flavor of bacon. The aims of this study were to detect bacterial community succession using high-throughput sequencing (HTS) and volatile flavor compound changes using gas chromatography-ion mobility spectrometry (GC-IMS) during the production of Zhenba bacon. The results showed that a total of 70 volatile compounds were detected.

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Primary myelofibrosis (PMF) is an infrequent etiology of noncirrhotic portal hypertension (PH). In clinical settings, non-cirrhotic PH is often misdiagnosed as cirrhotic PH. This case report details a patient who exhibited recurrent esophageal variceal hemorrhage and was initially misdiagnosed with cirrhosis.

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Background: Traumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that measure average changes at tissue levels and fail to capture the complexity and heterogeneity of the affected tissues. Spatial proteomics offers a solution by providing insights into sub-region-specific alterations within tissues. This study focuses on the hippocampal sub-regions, analyzing proteomic expression profiles in mice at the acute (1 day) and subacute (7 days) phases of post-TBI to understand subregion-specific vulnerabilities and long-term consequences.

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Introduction: Fully covered self-expandable metal stents (FCSEMSs) are commonly placed in patients with biliary stricture during endoscopic retrograde cholangiopancreatography (ERCP). However, up to 40% of migration has been reported, resulting in treatment failure or the requirement for further intervention. Here, we aimed to investigate the effects of metal clip anchoring on preventing the migration of FCSEMS.

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  • The study investigates how effective combining stent retriever mechanical thrombectomy with tirofiban is for treating acute ischemic stroke.
  • Results show that this combination significantly improves treatment effectiveness, recanalization rates, and reduces the number of stent retrieval operations compared to stent retriever alone.
  • The combined treatment also leads to better neurological function and daily living activities without substantially increasing risks for patients.
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  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to complex outcomes in children with asthma, whose antiviral immunity could be affected by their condition.
  • This study evaluated SARS-CoV-2 immunity in 53 children with asthma, examining their infection or vaccination history alongside their immune responses to common allergens like dust mites and cockroaches.
  • Results showed that children with atopic asthma had lower antibody responses and neutralization ability against SARS-CoV-2, suggesting that asthma mechanisms might hinder the development of lasting immunity and increase the risk of recurrent infections.
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Background: Hip fractures account for 23.8% of all fractures in patients over the age of 75 years. More than half of these patients are older than 80 years.

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Ethnic Pharmacological Relevance: Anxiety or depression after percutaneous coronary intervention (PCI) is a common clinical disease. Currently, conventional pharmacotherapy primarily involves the administration of anxiolytic or antidepressant medications in conjunction with anticoagulants, antiplatelet agents, and other cardiovascular drugs. However, challenges such as drug dependence, adverse reactions and related concerns persist in the treatment of this disease.

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  • Osteofibrous dysplasia (OFD) commonly affects the tibia, leading to deformities and fractures; traditional surgical treatments pose risks and complications.* -
  • This study analyzed the outcomes of 4 children who underwent a new minimally invasive procedure combining tibial osteotomy with telescopic rod fixation to treat OFD-related tibial bowing.* -
  • Results showed no complications or deformity recurrence, with successful bone healing in an average of 3 months and significant improvements in function as measured by the MSTS score.*
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This study aimed to assess the effect of a phase-change material (PCM) cooling blanket for cooling between exercise bouts on recovery of physiological parameters and subsequent exercise performance in the heat. Eighteen male volunteers were recruited to participate in human trials involving two exhaustive treadmill running bouts (Bout1 for 3 km and Bout2 for 1.5 km) in a climate chamber (temperature = 33 °C; relative humidity = 40%).

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