Hyaluronic acid/tannic acid hydrogel sunscreen with excellent anti-UV, antioxidant, and cooling effects.

Excessive exposure to UV radiation is one of the major factors that causes skin aging, erythema, burns, and skin cancer. Recently, the usage of sunscreens for skin protection has increased because the amount of UV radiation reaching the Earth's surface has increased owing to the destruction of the ozone layer that blocks UV radiation. Hydrogels with a three-dimensional network structure exhibit physical and chemical properties that are similar to those of the extracellular matrix in the human body, a high water content, flexibility, and biocompatibility.

Effect of tannic acid on the mechanical and adhesive properties of catechol-modified hyaluronic acid hydrogels.

Hyaluronic acid (HA) is applied in various fields, including pharmaceutical science, owing to its favorable biological properties such as moisture retention, non-toxicity, biodegradability, biocompatibility and biodegradability. In particular, many studies have aimed at its application in the form of a hydrogel. However, the applications of HA hydrogels are limited owing to their poor mechanical properties.

Self-crosslinkable hyaluronate-based hydrogels as a soft tissue filler.

With increasing interest in aging and skin care, the use of fillers to increase the volume of soft tissue volume is increasing globally. However, the side effects caused by the residual chemical crosslinking agents present in these fillers limit the effective application of commercialized filler products. Therefore, the development of a novel crosslinking system with a non-toxic chemical crosslinking agent is required to overcome the limitations of commercial hyaluronate (HA)-based fillers.

Visible-light-induced hyaluronate hydrogel for soft tissue fillers.

Hyaluronic acid (HA) is widely used as a filler owing to its excellent biocompatibility and biodegradability. However, commercial HA-based filler products have some limitations and can cause side effects due to the presence of residual chemical crosslinking agents. In this study, tyramine (Tyr) was introduced into HA to impart photocrosslinking ability to HA, and a photocrosslinked hydrogel was formed using a less toxic vitamin B2 derivative as a photoinitiator.

Effect of photoinitiator on chain degradation of hyaluronic acid.

Objectives: Photocrosslinking systems of polymers have been widely studied using UV or visible light irradiation. However, the photodegradation behavior derived from light irradiation was rarely reported, comparing with the photocrosslinking. In this study, the tyramine-modified hyaluronic acid (HA/Tyr) hydrogel was prepared using riboflavin (RF) as a photoinitiator, and the degradation behavior of HA by the reactive oxygen species (ROS) generated in photochemical process was investigated.