Publications by authors named "Bo Lorenzo Dal"
Ritodrine hydrochloride ((R,S)-4-hydroxy-alpha-[1-[2-((4-hydroxyphenyl)ethyl]amino)ethyl]benzenemethanol, CAS 26652-09-5) is a direct-acting sympathomimetic agent with a predominant beta-adrenergic activity and a selective action on beta2-receptors. A clinical trial was carried out to investigate the pharmacokinetics, pharmacodynamics and safety of ritodrine hydrochloride administered at the doses of 10, 20 and 30 mg p.o.
View Article and Find Full Text PDFTandem mass spectrometry (LC-MS-MS): a predominant role in bioassays for pharmacokinetic studies.
Arzneimittelforschung
April 2007
Plasma concentrations of drugs and drug metabolites in bioavailability studies are routinely bioassayed with high performance liquid chromatography (HPLC), gas chromatography (GC), and liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS) methods. In the 1980s and 1990s, HPLC had achieved a relevant role compared to GC and other techniques in pharmacokinetic bioassays. However, in the last few years the LC-MS-MS technique, known as tandem mass spectrometry, has attained a predominant role over all other techniques.
View Article and Find Full Text PDFBioequivalence study of fluoxetine hydrochloride in healthy volunteers.
Arzneimittelforschung
November 2005
Article Synopsis
- Fluoxetine hydrochloride is a widely-used SSRI antidepressant, and this trial aimed to compare a new formulation of the drug to a reference product from Switzerland using 20 mg dispersible tablets.
- The study involved 30 healthy male volunteers and utilized advanced mass spectrometry to measure drug levels, finding that while fluoxetine and its metabolite, norfluoxetine, have different plasma profiles, both formulations were statistically shown to be bioequivalent.
- Results indicated that the peak concentrations and half-lives of both formulations were acceptable, with no significant differences in safety and tolerability, concluding that the new formulation is equivalent to the reference product.