Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT.

Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for relapsing forms of multiple sclerosis (MS) that are refractory to disease-modifying therapy (DMT). AHSCT after failure of high-efficacy DMT in aggressive forms of relapsing-remitting MS is a generally accepted indication, yet the optimal placement of this approach in the treatment sequence is not universally agreed upon. Uncertainties also remain with respect to other indications, such as in rapidly evolving, severe, treatment-naive MS, progressive MS, and neuromyelitis optica spectrum disorder (NMOSD).

COL1A1, COL1A2, CHN1, and FN1 Promote Tumorogenesis and Act as Markers of Diagnosis and Survival in Gastric Cancer Patients.

Objectives: This study aimed to comprehensively investigate the molecular landscape of gastric cancer (GC) by integrating various bioinformatics tools and experimental validations.

Methodology: GSE79973 dataset, limma package, STRING, UALCAN, GEPIA, OncoDB, cBioPortal, DAVID, TISIDB, Gene Set Cancer Analysis (GSCA), tissue samples, RT-qPCR, and cell proliferation assay were employed in this study.

Results: Analysis of the GSE79973 dataset identified 300 differentially expressed genes (DEGs), from which COL1A1, COL1A2, CHN1, and FN1 emerged as pivotal hub genes using protein-protein interaction network analysis.

Nasal mask versus conventional oxygen supply for endoscopy under intravenous sedation: protocol for a systematic review and meta-analysis.

Introduction: Hypoxaemia is a frequent complication associated with endoscopy conducted under intravenous sedation, highlighting the need for effective and practical interventions. This systematic review aims to evaluate the effectiveness of nasal mask oxygenation in reducing the incidence of hypoxaemia during endoscopy under intravenous sedation compared with the conventional oxygen supply.

Methods And Analysis: This study strictly adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol guidelines.

A case study on risk assessment and novel anchoring technology for potential collapse of high and steep giant dangerous rock mass.

Dangerous rock masses in mountainous areas seriously threaten the construction and operation of engineering with potential disaster hazards, especially the unpredictability and sudden occurrence of rockfall, which poses a huge challenge. This paper presents a systematic risk assessment and disposal of high and steep giant dangerous rock masses, which can pose a serious threat to railway operation. Using comprehensive methods such as on-site investigation, limit equilibrium method, and simulation analysis of rockfall trajectory, the possibility and potential harm of collapse and rockfall of giant dangerous rock masses are analyzed and corresponding remediation measures are proposed.

Na-K-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats.

Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutamate (Glu) excitotoxicity plays a critical role. The most important Glu transporter, GLT-1, is essential for the regulation of Glu, which is dependent on Na-K-ATPase (NKA)-induced ion concentration gradient differences.

Knowledge, attitude, and practice toward foodborne disease among Chinese college students: a cross-sectional survey.

Background: More than 200 diseases are caused by eating food contaminated and the burden of foodborne disease is considered to be high worldwide. Foodborne diseases are an important public health issue, and the knowledge, attitudes and practices among college students are crucial in preventing outbreaks.

Objective: This study aimed to evaluate the current knowledge, attitudes, and practices (KAP) toward foodborne diseases among Chinese college students and to identify the factors influencing practice actions.

Research progress on gene mutations and drug resistance in leukemia.

Leukemia is a type of blood cancer characterized by the uncontrolled growth of abnormal cells in the bone marrow, which replace normal blood cells and disrupt normal blood cell function. Timely and personalized interventions are crucial for disease management and improving survival rates. However, many patients experience relapse following conventional chemotherapy, and increasing treatment intensity often fails to improve outcomes due to mutated gene-induced drug resistance in leukemia cells.

Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion.

Objective: To explore the biological relationship between the regulatory signal pathways involved in differentially expressed genes and recurrent spontaneous abortion (RSA) by analyzing the gene expression microarray data of unexplained RSA.

Methods: The gene expression profile data of chorionic villi from unexplained recurrent abortion with normal karyotype and selective induced abortion were compared. Differentially expressed genes were analyzed by the "Limma" package in R Studio, and Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out with "Cluster Profiler" and "org.

Road terrain recognition based on tire noise for autonomous vehicle.

Effective road terrain recognition is crucial for enhancing the driving safety, passability, and comfort of autonomous vehicles. This study addresses the challenges of accurately identifying diverse road surfaces using deep learning in complex environments. We introduce a novel end-to-end Tire Noise Recognition Residual Network (TNResNet) integrated with a time-frequency attention module, designed to capture and leverage time-frequency information from tire noise signals for road terrain classification.

UV-activated gas sensor based on ordered mesoporous ZnO-TiO heterogeneous composites for trace NO detection at room temperature.

The growing modern industry has promoted the development of gas sensors for environmental monitoring and safety checks. However, the traditional chemical resistance gas sensor still has some disadvantages such as high power consumption and limited detection, mainly due to the lack of charge transfer ability of sensing materials. In this paper, an ordered UV-activated gas sensor with mesoporous ZnO/TiO nanotube composite was prepared by precisely controlling the growth of ZnO on the inner wall of TiO nanotube.

ALKBH1: emerging biomarker and therapeutic target for cancer treatment.

As neoplastic cells proliferate, disseminate, and infiltrate, they undergo substantial alterations in their epigenetic configuration. Among the pivotal enzymes implicated in this phenomenon is the AlkB family of demethylases, notably AlkB homolog 1 (ALKBH1), which demonstrates conspicuous upregulation across various malignancies. The heightened expression of ALKBH1 renders it a compelling candidate for the development of multifaceted anticancer modalities.

Enhanced path tracking control of hydraulic support pushing mechanism via adaptive sliding mode technique in coal mine backfill operations.

The hydraulic support pushing mechanism is the primary equipment utilized in coal mine backfill operations, playing a crucial role in enhancing filling efficiency, ensuring a stable filling body, and managing gob safety. This paper focuses on analyzing the dynamic model and the interrelationship of the hydraulic cylinder, which serves as the power source for the pushing mechanism. To address the intricate coupling effects arising from the hydraulic cylinders and the displacement-force induced by the shared pump, this study employs feedforward compensation for decoupling analysis.

Development and application of the Demands for Population Health Interventions (Depth) framework for categorising the agentic demands of population health interventions.

Background: The 'agentic demand' of population health interventions (PHIs) refers to the capacity, resources and freedom to act that interventions demand of their recipients to benefit, which have a socio-economical pattern. Highly agentic interventions, e.g.

Mechanism of removal of Sb from printing and dyeing wastewater by a novel titanium-manganese binary oxide.

Antimony (Sb) is a toxic heavy metal that endangers both the environment and human health. In response to the growing need for efficient Sb removal from printing and dyeing wastewater (PDW), this study introduces a novel titanium-manganese binary oxide adsorbent (T2M1BO) synthesized via precipitation. Experimental results show that T2M1BO exhibited higher absorption efficiency for Sb(III) compared to Sb(V), with maximum adsorption capacities recorded at 323.

Airborne Acoustic Vortex End Effector-based Contactless, Multi-mode, Programmable Control of Object Surfing.

Tweezers based on optical, electric, magnetic, and acoustic fields have shown great potential for contactless object manipulation. However, current tweezers designed for manipulating millimeter-sized objects such as droplets, particles, and small animals, exhibit limitations in translation resolution, range, and path complexity. Here, we introduce a novel acoustic vortex tweezers system, which leverages a unique airborne acoustic vortex end effector integrated with a three degree-of-freedom (DoF) linear motion stage, for enabling contactless, multi-mode, programmable manipulation of millimeter-sized objects.

Research Progress on Applying Intelligent Sensors in Sports Science.

Smart sensors represent a significant advancement in modern sports science, and their effective use enhances the ability to monitor and analyze athlete performance in real time. The integration of these sensors has enhanced the accuracy of data collection related to physical activity, biomechanics, and physiological responses, thus providing valuable insights for performance optimization, injury prevention, and rehabilitation. This paper provides an overview of the research progress in the application of smart sensors in the field of sports science; highlights the current advances, challenges, and future directions in the deployment of smart sensor technologies; and anticipates their transformative impact on sports science and athlete development.

Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma.

α5-nicotinic acetylcholine receptor (α5-nAChR) plays a vital part in lung adenocarcinoma (LUAD). However, it is not comprehensively understood that how the α5-nAChR affects LUAD. Through diverse bioinformatics analyses and immunohistochemistry, the expressions of α5-nAChR and SOX2 as well as their relations were dissected.

The efficacy of preemptive multimodal analgesia in elderly patients undergoing laparoscopic colorectal surgery: a randomized controlled trial.

Objective To evaluate the effectiveness of preemptive multimodal analgesiain elderly patients undergoing laparoscopic colorectal surgery. Methods A prospective randomized controlled study was conducted in the Department of Gastrointestinal Surgery of the Second Hospital of Hebei Medical University from January 2022 to December 2022. A total of 133 patients were included according to the criteria and randomly divided into preemptive analgesia (PRA) group (test group, 67patients) and postoperative analgesia (POA) group (control group, 66patients).

Immune Checkpoint VISTA Negatively Regulates Microglia Glycolysis and Activation via TRIM28-Mediated Ubiquitination of HK2 in Sepsis-Associated Encephalopathy.

V-domain immunoglobulin suppressor of T cell activation (VISTA) has emerged as a crucial player in the pathogenesis of neurological disorders. However, the specific mechanism by which VISTA regulates microglial activation remains unclear. Septic mice were intracerebroventricularly injected with an agonistic anti-VISTA antibody or isotype control.

Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin-angiotensin system on inflammation and oxidative stress.

Background: Age-related reproductive aging is a natural and irreversible physiological process, and delaying childbearing is increasingly common all over the world. Transplantation of mesenchymal stem cells (MSCs) is considered a new and effective therapy to restore ovarian function, but the relevant mechanisms remain unclear. Recently, it has been found that there is a local Renin-angiotensin system (RAS) in human ovary and it plays a key role.

Perioperative oxygen administration for adults undergoing major noncardiac surgery: a narrative review.

Perioperative oxygen administration, a topic under continuous research and debate in anesthesiology, strives to optimize tissue oxygenation while minimizing the risks associated with hyperoxia and hypoxia. This review provides a thorough overview of the current evidence on the application of perioperative oxygen in adult patients undergoing major noncardiac surgery. The review begins by describing the physiological reasoning for supplemental oxygen during the perioperative period and its potential benefits while also focusing on potential hyperoxia risks.

A method for determining potential parental contamination: linkage disequilibrium-based log-likelihood ratio analysis for IVF-PGT.

Background: At present, embryologists are attempting to use conventional in vitro fertilization (cIVF) as an alternative to intracytoplasmic sperm injection (ICSI) for preimplantation genetic testing (PGT). However, the potential parental contamination origin of sperm cells and cumulus cells is considered the main limiting factor in the inability of cIVF embryos to undergo PGT.

Methods: In this study, we established an IVF-PGTA assay for parental contamination tests with a contamination prediction model based on allele frequencies and linkage disequilibrium (LD) to compute the log-likelihood ratio (LLR) under competing ploidy hypotheses, and then verified its sensitivity and accuracy.

The Therapeutic Potential of Exosomes from Mesenchymal Stem Cells in Multiple Sclerosis.

Although treatment for multiple sclerosis (MS) has undergone a revolution in the last decades, at least two important barriers remain: alleviation of innate inflammation driving disease progression and promotion of remyelination and neural regeneration. Mesenchymal stem cells (MSCs) possess immunomodulatory properties and promote remyelination in murine MS models. The main therapeutic mechanism has, however, been attributed to their potent paracrine capacity, and not to in vivo tissue implantation.