Ultrasound-Assisted H Transmitter Enables Hydrogen-Gene Therapy to Prevent Anesthesia/Surgery-Induced Cognitive Impairment.

Postoperative cognitive dysfunction (POCD) frequently occurs after surgery, resulting in extended hospitalizations, higher healthcare expenses, and potential long-term cognitive impairment. Despite its significant impact, effective preventive and therapeutic strategies for POCD are still lacking. Neuroinflammation plays a crucial role in the pathogenesis of POCD.

Dephenolization Methods, Quality Characteristics, Applications, and Advancements of Dephenolized Cottonseed Protein: Review.

Dephenolized cottonseed protein is a high-protein product obtained through the further dephenolization of cottonseed meal or by removing the lint and shell of cottonseed, extracting the oil at a low temperature, and subsequently eliminating toxic substances (gossypol). This paper presents a review of the latest advancements in the dephenolization methods, quality characteristics, and application domains of dephenolized cottonseed protein. It focuses on enhanced dephenolization methods, and summarizes the composition, structural characteristics, functional properties, and recent research developments.

Quality and composition control of complex TCM preparations through a novel "Herbs-in vivo Compounds-Targets-Pathways" network methodology: The case of Lianhuaqingwen capsules.

Lianhuaqingwen (LHQW) capsules, a Chinese patent medicine composed of 13 herbal ingredients, are widely used for respiratory diseases. However, the complex composition of LHQW poses challenges in assessing its quality and consistency. In this study, a comprehensive network of LHQW was constructed by integrating Digital RNA with pertUrbation of Genes (DRUG)-seq, RNA sequencing, and pharmacodynamic data.

Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age ≥ 15 y) to generate intracellular and dynamic serum metabolomic profiles. Our findings revealed a predominant increase in bile acid (BA) metabolites in serum, alongside metabolic rewiring that supported highly proliferative states and actively metabolic signaling, such as enriched nucleotide metabolism in leukemic blasts.

Integrated metabolomic and transcriptomic analysis of anthocyanin metabolism in wheat pericarp.

Background: Wheat seeds display different colors due to the types and contents of anthocyanins, which is closely related to anthocyanin metabolism. In this study, a transcriptomic and metabolomic analysis between white and purple color wheat pericarp aimed to explore some key genes and metabolites involved in anthocyanin metabolism.

Results: Two wheat cultivars, a white seed cultivar Shiluan02-1 and purple seed cultivar Hengzi151 were used to identify the variations in differentially expressed genes (DEGs) and differentially accumulated flavonoids (DAFs).

Transcriptomic Analysis of Wheat Under Multi LED Light Conditions.

Light is a vital environmental cue that profoundly influences the development of plants. LED lighting offers significant advantages in controlled growth environments over fluorescent lighting. Under monochromatic blue LED light, wheat plants exhibited reduced stature, accelerated spike development, and a shortened flowering period with increased blue light intensity promoting an earlier heading date.

A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) is an aging-related malignancy, with patients aged ≥60 years old facing significantly poorer prognosis. Umbilical cord blood (UCB) has emerged as a promising source with effective anti-aging roles. Here, we conducted a prospective, phase 2, single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients (ChiCTR-OPC-15006492).

Therapeutic potential of omentin-1 in preeclampsia: enhancing fetal outcomes, vascular function, and reducing inflammation.

This study evaluated the therapeutic potential of omentin-1 in preeclampsia (PE), focusing on fetal outcomes, vascular function, and inflammation. A PE-like mouse model received recombinant human omentin-1 protein (rh-omentin) from gestation day (gd) 13.5 to 16.

Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia.

Microglia-mediated neuroinflammation demonstrates a crucial act in the progression of neuropathic pain. Oxidative damage induced by reactive oxygen species (ROS) derived from NADPH oxidase (NOX) in microglia drives proinflammatory microglia activation. Recent evidence points to the central renin angiotensin system (RAS) is involved in oxidative stress and neuroinflammation, with the angiotensin converting enzyme/angiotensin II/angiotensin receptor-1 (ACE/Ang II/AT1R) axis promoting inflammation through increased ROS production, counteracted by the ACE2/Ang (1-7)/Mas receptor (MasR) axis.

Effects of ethanol addition on the quality and stability of Pickering emulsions: Developing Baijiu-infused ice cream.

The application of Pickering emulsions in real food systems has attracted increasing research interest. Similarly, the tendency of incorporation of Chinese Baijiu into food products is also increasing. This study aimed to investigate the effects of ethanol addition (3 %-15 %, v/v) on the physicochemical, rheological properties and microstructure of Pickering emulsions.

Vitamin D Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKCα/NOX4 Signaling Pathway.

Aims: Neuropathic pain remains a significant unmet medical challenge due to its elusive mechanisms. Recent clinical observations suggest that vitamin D (VitD) holds promise in pain relief, yet its precise mechanism of action is still unclear. This study explores the therapeutical role and potential mechanism of VitD in spared nerve injury (SNI)-induced neuropathic pain rat model.

Study on crystal and amorphous transformation of ultrasonic vibration assisted laser cladded Fe-based amorphous coatings.

In order to investigate the influence of ultrasonic vibration (UV) on microstructural evaluation of amorphous coating, the Fe-based amorphous (FeCoCrMoCBYAl) coatings with and without UV were fabricated by laser cladding technology. The microstructure and corrosion resistance of the coatings were studied in detail to understand the mechanism of the UV on amorphous coatings. It can be found that the cavitation effect generated by UV refines and breaks the columnar crystals at the interface.

Identification of Wheat Glutamate Synthetase Gene Family and Expression Analysis under Nitrogen Stress.

Nitrogen (N), as the main component of biological macromolecules, maintains the basic process of plant growth and development. GOGAT, as a key enzyme in the N assimilation process, catalyzes α-ketoglutaric acid and glutamine to form glutamate. In this study, six genes in wheat ( L.

The role of HMGB1 on SiC NPs-induced inflammation response in lung epithelial-macrophage co-culture system.

In recent years, carbonized silicon nanoparticles (SiC NPs) have found widespread scientific and engineering applications, raising concerns about potential human health risks. SiC NPs may induce pulmonary damage through sustained inflammatory responses and oxidative stress, with unclear toxicity mechanisms. This study uses an in vitro co-culture model of alveolar macrophages (NR8383) and alveolar epithelial cells (RLE-6TN) to simulate the interaction between airway epithelial cells and immune cells, providing initial insights into SiC NP-triggered inflammatory responses.

Sampling unknown large networks restricted by low sampling rates.

Graph sampling plays an important role in data mining for large networks. Specifically, larger networks often correspond to lower sampling rates. Under the situation, traditional traversal-based samplings for large networks usually have an excessive preference for densely-connected network core nodes.

The third strategy: modulating emission colors of organic light-emitting diodes with UV light during the device fabrication process.

The modulation of emission color is one of the most critical topics in the research field of organic light-emitting diodes (OLEDs). Currently, only two ways are commonly used to tune the emission colors of OLEDs: one is to painstakingly synthesize different emitters with diverse molecular structures, the other is to precisely control the degree of aggregation or doping concentration of one emitter. To develop a simpler and less costly method, herein we demonstrate a new strategy in which the emission colors of OLEDs can be continuously changed with UV light during the device fabrication process.

Histone deacetylase as emerging pharmacological therapeutic target for neuropathic pain: From epigenetic to selective drugs.

Background: Neuropathic pain remains a formidable challenge for modern medicine. The first-line pharmacological therapies exhibit limited efficacy and unfavorable side effect profiles, highlighting an unmet need for effective therapeutic medications. The past decades have witnessed an explosion in efforts to translate epigenetic concepts into pain therapy and shed light on epigenetics as a promising avenue for pain research.

Characteristics of Pickering emulsions stabilized by microgel particles of five different plant proteins and their application.

Pickering emulsions stabilized by protein particles are of great interest for use in real food systems. This study was to investigate the properties of microgel particles prepared from different plant proteins, i.e.