Publications by authors named "Bo Han Ren"
The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.
Acta Neuropathol
September 2020
Article Synopsis
- Pituitary adenomas (PAs) are common brain tumors, with prolactinomas making up about 40% of cases.
- Dopamine agonists like cabergoline are effective treatments for these tumors, but the regulation of the dopamine receptor DRD2, essential for treatment efficacy, is not fully understood.
- This study identifies KBTBD7 as a protein that interacts with and promotes the degradation of DRD2, impacting the sensitivity of pituitary tumors to dopamine agonists and suggesting KBTBD6/7 as a potential therapeutic target.