Comprehensive analysis of butyric acid impact on immunology, histopathology, gene expression, and metabolomic responses in pacific shrimp experiencing cold stress.

In this study, our objective was to investigate the impact of dietary butyric acid (BA) on the homeostasis mechanism of Pacific shrimp under cold stress. Specifically, we analyzed its effects on immunity, antioxidant capacity, gene expression, and metabolomics response. To carry out this research, Litopenaeus vannamei were fed a diet supplemented with BA for 8 weeks.

Protective effects of butyric acid during heat stress on the survival, immune response, histopathology, and gene expression in the hepatopancreas of juvenile pacific shrimp (L. Vannamei).

This study looked at the effects of adding butyric acid (BA) to the diets of juvenile Pacific shrimp and how it affected their response to survival, immunity, histopathological, and gene expression profiles under heat stress. The shrimp were divided into groups: a control group with no BA supplementation and groups with BA inclusion levels of 0.5 %, 1 %, 1.

Constructing of efficient interface solar evaporator: In-situ colloid foaming strategy for solar desalination and visible light response sewage purification.

The shortage of drinking water has become a global problem, coastal cities can make full use of abundant seawater resources by desalination technology to ease the contradiction between supply and demand. However, fossil energy consumption contradicts the goal of reducing carbon dioxide emissions. Currently, researchers favor interfacial solar desalination devices relying only on clean solar energy.

Design of an interface heating device based on polydivinylbenzene/SiO/BiWO and its visible light response performance for water purification.

Environmental pollution and the shortage of drinking water are the challenges that mankind is facing. Solar interface evaporation technology has been demonstrated as an important method for producing clean water, but its application to sewage still faces problems, mainly manifested in solubility and oily pollutants. Therefore, an evaporator device contains a superhydrophobic BiWO felt floating layer, a filter paper hydrophilic layer, and a copper foam/CuO photothermal layer, of which the water contact angle of the superhydrophobic felt can reach 159°.

Hierarchical manganese valence gradient MnO phosphorus doping for cathode materials with improved stability.

The search for a method for enhancing the electrochemical performance of manganese dioxide is still a challenge. Herein, we report a rod-like P-MnO cathode material with a hierarchical manganese gradient valence through the phosphatization process. For the incorporation of P, MnO was formed on the surface of MnO and exhibited a gradient valence structure, while the oxygen defect concentration in P-MnO increased.

Effects of female obesity on conception, pregnancy and the health of offspring.

As we all know, female obesity has become a global epidemic, which is usually accompanied with endocrine and metabolic disorders. Obese women are more likely to experience reproductive problems, including infertility, embryonic developmental defects and abnormality in offspring. Female obesity is a complex multifactorial condition, where there are many mechanisms involved in the effects of overweight and obesity on the development of these reproductive disorders.

Effect of percutaneous nephrolithotripsy under guidance of B-ultrasound for the treatment of complex renal calculi.

The purpose of this study was to investigate the effect of percutaneous nephrolithotripsy guided by B-ultrasound in the treatment of complex renal calculi. A total of 82 patients with complex renal calculi were selected, who underwent percutaneous nephrolithotripsy guided by B-ultrasound. The average operation time was 101.

Design of Superhydrophobic CoFeO Solar Seawater Desalination Device and Its Application in Organic Solvent Removal.

Environmental pollution and clean water production are challenges to the development of human society. In this paper, devices consisting of a superhydrophobic Ni-CoFeO foam layer (floating layer), a hydrophilic channel and a superhydrophilic Ni-CoFeO foam layer (photothermal conversion layer) were designed. The light energy was converted into heat on the photothermal layer, for which the hydrophilic channel provided a small amount of water.

Zinc-Loaded Black Phosphorus Multifunctional Nanodelivery System Combined With Photothermal Therapy Have the Potential to Treat Prostate Cancer Patients Infected With COVID-19.

Since 2019, coronavirus disease 2019 (COVID-19) has swept the world and become a new virus threatening the health of all mankind. The survey found that prostate cancer accounts for one in three male cancer patients infected with COVID-19. This undoubtedly makes prostate cancer patients face a more difficult situation.

Versatile superhydrophobic bismuth molybdate cotton fabric for oil/water separation and decompose dyestuff.

Water pollution caused by the discharged insolubility petroleum contaminants and organic compound dyes seriously threatens the natural self-purity capacity of the water body and the survival of aquatic species, so it is imperative to restraint the deterioration of the aquatic environment. In this paper, pathways are propounded for the simultaneous removal of insoluble spilling oil and organic dye contaminants. Particularly, hydrophobic ZnSnO after stearic acid modification and BiMoO photocatalysts are introduced into the cotton fabric substrate through solution dip-coating.

Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment.

Dipeptidyl peptidase-4 (DPP4) has been proven to exert its functions by both enzymatic and nonenzymatic pathways. The nonenzymatic function of DPP4 in diabetes-associated cognitive impairment remains unexplored. We determined DPP4 protein concentrations or its enzymatic activity in type 2 diabetic patients and db/db mice and tested the impact of the non-enzymatic function of DPP4 on mitochondrial dysfunction and cognitive impairment both in vivo and in vitro.

Fabrication of visible-light response cadmium sulfide modified superhydrophobic surface for water resource remediation.

Widespread concern has been attached to the frequent occurrence of pollution by oil slicks and water-soluble pollutants in recent years. The semiconductor photocatalysis is applied to sewage treatment owing to the advantages of energy-conserving and environmental protection. However, its application is limited by the defects of not solving oil slicks and the hard recyclability.

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis.

Pachymic acid (PA), a bioactive ingredient isolated from Poria cocos Wolf, is reported with potential benefits of anti-inflammatory, anti-oxidative actions. It is reasoned that PA may play the potential benefits against cystitis glandularis (CG), an inflammation of the bladder tissue. In this study, we aimed to apply the network pharmacology and molecular docking analyses to reveal concrete anti-CG targets and mechanisms of PA, and then the bioinformatic findings were verified by using clinical and animal samples.

Superhydrophobic Self-Supporting BiOBr Aerogel for Wastewater Purification.

This research was focused on the raw material level construction of bismuth oxybromide (BiOBr) catalysis-loaded 3D cross-linked network polyurethane (PU) foam via the in situ polymerization method. After modification of superhydrophobic polydivinylbenzene nanoparticles, the PU foam possessed excellent superhydrophobic stability. The larger selective absorption oil phase capacity depended on its macroporous structure, and the existence of catalyst BiOBr (the band gap energy was about 2.

Zinc Ion-Stabilized Aptamer-Targeted Black Phosphorus Nanosheets for Enhanced Photothermal/Chemotherapy Against Prostate Cancer.

Prostate cancer is the second most common malignancy among men worldwide. However, conventional chemotherapy, such as taxane therapy, fails to exhibit efficient treatment for almost half of the patients. In this study, a nano-drug delivery system based on black phosphorus nanosheets (BP NSs) was developed, which was then employed as a multifunctional nanoplatform for targeted combinational chemo-photothermal therapy against prostate cancer.

Poor bladder compliance due to malacoplakia with xanthogranulomatous cystitis: A case report.

Rationale: Either malacoplakia or xanthogranulomatous cystitis (XC) is a rare chronic infection disease of urinary bladder, which often mimics bladder masses undifferentiated from malignance and results in severe lower urinary tract symptoms. The malacoplakia combined with XC is even rarer in the literature.

Patient Concerns: A 64-year-old female, who presented with nocturia, frequency of micturition, severe urgency with occasional urinary incontinence, and recurrent hematuria for >2 years, was diagnosed with azotemia and anemia.

Association of Plasma DPP4 Activity and Brain-Derived Neurotrophic Factor With Moderate to Severe Depressive Symptoms in Patients With Type 2 Diabetes: Results From a Cross-Sectional Study.

Objective: The objective of this study was to assess the association of plasma dipeptidyl peptidase-4 (DPP4) activity, brain-derived neurotrophic factor (BDNF), and the DPP4/BDNF ratio (DBR) with moderate to severe depressive symptoms in patients with type 2 diabetes mellitus. Increased DPP4 activity and decreased BDNF in peripheral circulation have been implicated in the pathophysiology of depression.

Methods: We performed a cross-sectional study using data from 1535 patients with type 2 diabetes mellitus.

Association between plasma dipeptidyl peptidase-4 activity to brain-derived neurotrophic factor ratio and depressive symptoms in middle-aged and older adults with normal glucose tolerance: A cross-sectional study.

Attenuation of brain-derived neurotrophic factor (BDNF) availability and increased dipeptidyl peptidase-4 (DPP4) activity have both been reported to link to the pathogenesis of depression. The aim of this study was to test the correlation between depressive symptoms and plasma DPP4 activity to BDNF ratio (DBR). We evaluated DPP4 activity, BDNF, oxidative stress parameters and inflammatory markers and calculated DBR in a cross-sectional sample of 1640 non-diabetic participants.

Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.

Background: Our present study aimed to unravel the therapeutic biotargets of vitamin C (VC) against cystitis glandularis (CG), and to elucidate the molecular mechanisms for VC treating CG.

Methods: Network pharmacology was used to predict therapeutic targets of VC against CG, and to identify molecular mechanisms. In addition, further human and animal studies were designed to validate the bioinformatic findings through biochemical tests, computerized tomography scans, and immunostaining assays.

The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance.

Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF ratio (DBR) in an elderly population with normal glucose tolerance. We cross-sectionally measured C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity BDNF and calculated the DBR in a total of 1,066 elderly participants in China. MCI was determined by the Montreal Cognitive Assessment and finally confirmed by neurologists.

Knockdown of lncRNA SNHG7 inhibited cell proliferation and migration in bladder cancer through activating Wnt/β-catenin pathway.

It is identified that long non-coding RNAs (lncRNAs) play important roles in tumorigenesis. LncRNA SNHG7 has been found to be an oncogene in varieties of tumors including bladder cancer. However, its potential regulatory mechanism in bladder cancer still remains unknown.

Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China.

Unlabelled: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the relationship between ANGPTL8 and albuminuria in type 2 diabetes.

Obstruction of bifid ureter by two calculi: A case report.

Rationale: The duplex ureter is a common anomaly of urinary tract, but preoperative sonography, plain abdominal radiography, or nonenhanced computed tomography (CT) often overlooked it when involved with urinary tract obstruction. In this report, We present a rare case of left Y-shaped bifid ureter and both ureter of upper moiety and common stem were obstructed respectively by 2 calculi.

Patient Concerns: A 47-year-old woman was admitted due to 3-day history of left-sided loin pain and low-grade fever.

Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China.

Background: Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANGPTL8 and subclinical atherosclerosis in type 2 diabetes.

Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.

We investigated the molecular mechanism of curcumol-induced apoptosis in bladder cancer cells. The mitochondrial membrane potential was measured using JC-1 staining. ROS generation of bladder cancer cells was determined using the DCFH staining method.