Wogonin Attenuates Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress Injury via the MAPK Signaling Pathway.

Idiopathic pulmonary fibrosis (PF) is an irreversible and chronic inflammatory condition with limited therapeutic options and a high mortality rate. We aimed to determine the possible role and mechanisms of wogonin (WGN) on PF. A rat model of PF was established with intratracheally administrated with bleomycin (BLM), followed by intravenously injecting with WGN and weekly body weight measurements for four weeks.

Percutaneous microwave ablation for aldosterone-producing adenoma.

Thirty-five patients diagnosed with aldosterone-producing adenomas underwent CT-guided percutaneous microwave ablation (MWA). Comparisons of aldosterone-to-renin ratio (ARR), potassium level, blood pressure (BP), and medications were performed preoperatively, postoperatively, and at the latest follow-up examination. The outcome assessment was based on the primary aldosteronism surgical outcome (PASO) Standards.

A new paradigm for whole-chain low-carbon utilization of food waste secondary waste based on multivariate evaluations.

The rapid growth of China's food and beverage industry has led to a significant increase in food waste, presenting major challenges for its disposal. Anaerobic digestion is the primary treatment method, but its by-products-biogas slurry (BS) and biogas residue (BR)-pose additional treatment challenges. This study proposes and evaluates three management scenarios for these by-products: (1) BS sewage treatment with BR incineration (S1), (2) BS land application with BR composting (S2), and (3) BS sewage treatment with BR composting (S3).

Non-linear association of atherogenic index of plasma with bone mineral density a cross-sectional study.

Introduction: Although there has been abundant evidence of the association between dyslipidemia as a single factor and osteoporosis, the non-linear relationship between osteoporosis and the Atherogenic Index of Plasma (AIP) has not yet been thoroughly investigated. This study aimed to investigate the complex relationship between AIP and bone mineral density (BMD) to elucidate their interrelationship.

Methods: An analysis of 2007-2018 National Health and Nutrition Survey (NHANES) data was conducted for this study.

Circ_0104652 Promotes the Proliferation and Migration of ox-LDL-Stimulated Vascular Smooth Muscle Cells via Stabilizing ADAMTS7 and HMGB1.

Background: Atherosclerosis (AS) stands as the primary contributor to cardiovascular disease, a pervasive global health concern. Extensive research has underscored the pivotal role of circular RNAs (circRNAs) in cardiovascular disease development. However, the specific functions of numerous circRNAs in AS remain poorly understood.

Bioinspired stormwater control measure for the enhanced removal of truly dissolved polycyclic aromatic hydrocarbons and heavy metals from urban runoff.

Stormwater harvesting (SWH) addresses the UN's Sustainable Development Goals (SDGs). Conventional stormwater control measures (SCMs) effectively remove particulate and colloidal contaminants from urban runoff; however, they fail to retain dissolved contaminants, particularly substances of concern like polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs), thereby hindering the SWH applicability. Here, inspired by protein folding in nature, we reported a novel biomimetic SCM for the efficient removal of dissolved PAHs and HMs from urban runoff.

Organic binding iron formation and its mitigation in cation exchange resin assisted anaerobic digestion of chemically enhanced primary sedimentation sludge.

Fe based chemically enhanced primary sedimentation (CEPS) is an effective method of capturing the colloidal particles and inorganic phosphorous (P) from wastewater but also produces Fe-CEPS sludge. Anaerobic digestion is recommended to treat the sludge for energy and phosphorus recovery. However, the aggregated sludge flocs caused by the coagulation limited sludge hydrolysis and P release during anaerobic digestion process.

Exploration and validation of the hub genes involved in hypoxia-induced endothelial-mesenchymal transition of systemic sclerosis.

Objectives: During the development of systemic sclerosis (SSc), endothelial-mesenchymal transition (EndoMT) has been shown to be one of the mechanisms leading to pulmonary fibrosis. However, the correlation between hypoxia and EndoMT was mostly unknown.

Methods: R software was used to analyse differentially expressed genes (DEGs) in vascular endothelial cells under hypoxic conditions, and fibroblasts derived from SSc-related pulmonary fibrotic tissues, respectively.

Optimal emission reductions pathway for polybrominated diphenyl ethers in typical household e-waste dismantling products.

Waste printed circuit boards (WPCBs) and waste epoxy resin powder (WERP) generated after crushing are the most crucial hazardous materials in the recycling process of household e-waste. In this study, a sustainable treatment approach was established in response to the drawbacks of traditional treatment methods. The baseline and hypothetical scenarios were as follows: (1) scenario 1 (S1): WPCBs mechanical treatment, WERP safe landfill; (2) scenario 2 (S2): WPCBs mechanical treatment, WERP imitation stone bricks production.

Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on Aβ1-40-Induced Learning and Memory Deficit in Rats.

Alzheimer's disease (AD) is a neurodegenerative disease that has become a leading cause of death in recent years. The present study aimed to explore the possible prophylactic effects of Poria cocos essential oil (PCEO) against memory deficits in Aβ rats. Adult male Wistar rats were given Aβ1-42 via ICV injection.

Hydrothermal oxidation degradation of dioxins in fly ash with water-washing and added Ce-Mn catalyst.

A comprehensive analysis of the effects of the temperature, reaction time, liquid-solid ratio (L/S), and initial pH on the hydrothermal degradation of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) (which are both PCDD/Fs) in municipal solid waste incineration (MSWI) fly ash is presented. Consequently, the hydrothermal degradation reaction is catalyzed using Ce-Mn catalyst under low-temperature conditions to study the effect of the catalyst on the degradation efficiency of PCDD/Fs. The experimental results show that temperature is the most critical factor for the reaction.

Reduced Utilization Process Leaching Toxicity by Stabilizing Heavy Metals in Fly Ash from MSW Incineration Based on Hydrothermal Oxidation.

Hydrothermal oxidation is an effective approach to reduce leaching toxicity of fly ash from municipal solid waste incineration during utilization process. Herein, the effects of temperature, time, pH and Ce-Mn catalyst dosage on the stabilization of heavy metals in fly ash during hydrothermal oxidation were studied. The temperature of hydrothermal oxidation was positively correlated to the stabilization effect.

Analysis of mercury emissions and cycles in typical industrial city clusters: a case study in China.

China's Suzhou (SZ), Wuxi (WX), and Changzhou (CZ) (collectively referred to as the SXC area) have developed economies and advanced industrial production, which are typical industrial city clusters. To analyze the Hg flow characteristics, we quantified the Hg emissions and circulation according to six categories (including industrial production, agricultural livestock, vehicle exhaust, solid waste, atmospheric deposition, and runoff). The results showed that the Hg emission from coal accounting for 40.

A case of atypical reninoma with mild hypertension and normal plasma renin activity but elevated plasma renin concentration.

Background: Reninoma is a rare, benign renal neoplasm. Typical clinical features include severe hypertension, secondary hyperaldosteronism, hypokalaemia and metabolic alkalosis caused by the overproduction of renin.

Case Presentation: A 25-year-old lean Chinese woman with no family history of hypertension was hospitalized for stage 1 hypertension that gradually developed over two years.

Characteristics and long-term prognosis of patients with reduced, mid-range, and preserved ejection fraction: A systemic review and meta-analysis.

Aims: Patients with heart failure (HF) have a poor prognosis and are categorized by ejection fraction. We performed a meta-analysis to compare baseline characteristics and long-term outcomes of patients with heart failure with reduced (HFrEF), mid-range (HFmrEF), and preserved ejection fraction (HFpEF).

Methods And Results: A total of 27 prospective studies were included.

Co-utilization of lake sediment and blue-green algae for porous lightweight aggregate (ceramsite) production.

Lake sediment and algal sludge with large output posed significant environmental risks. In this work, an idea of co-utilization of both solid wastes for the production of ceramsite (a sort of porous lightweight aggregates as building materials) was proposed and validated for the first time. The treatment process contained a dewatering step by a flocculation-pressure filtration method, and a sintered ceramsite preparation step.

The change of water content and role of microbe in the sludge drying process.

In this study, the pure terephthalic acid sludge was treated by a drying process which was an economical and environmentally method. The water change and metabolic pathways for bacterial community function prediction were analyzed. The microbial community changes were studied by high-throughput sequencing to draw the dynamic succession model.

Performance and mechanism of high-speed vermicomposting of dewatered sludge using a new type of laboratory earthworm reactor.

To solve the problem of the traditional vermicomposting cycle being too long, a new type of laboratory earthworm reactor was developed for high-speed vermicomposting of sludge. The earthworm reactor was established based on the model of first creating an optimal living environment for earthworms and then introducing sludge into the environment for vermicomposting. In addition, we selected four different materials to condition sludge to optimize the treatment efficiency and shorten the vermicomposting cycle.

Pilot-scale vermicomposting of sewage sludge mixed with mature vermicompost using earthworm reactor of frame composite structure.

To improve the efficiency of sludge vermicomposting, a new cost-effective method is provided. It uses a new earthworm reactor with a frame composite structure for vermicomposting and reuses mature vermicompost to condition the sludge. Under the optimum conditions (proportion of earthworm droppings: 15%; thickness of sludge laying: 6 cm; moisture content of initial sludge mixture: 75%), the method of continuous operation described herein works well and presents three advantages compared with the traditional vermicomposting method: the short time required for vermicomposting (20.

Intensity analysis of chromium cycling in south Jiangsu region of China.

Suzhou (SZ), Wuxi (WX) and Changzhou (CZ) (collectively called the SXC area) in southern Jiangsu Province surround Tai Lake on three sides and have an important impact on its ecology. The emission and circulation of Cr in the three cities were quantified according to the six categories (including industry production, agricultural livestock, vehicle exhaust, solid waste, atmospheric subsidence and runoff) to analyze its regional characteristics and source category characteristics and to build a Cr cycle diagram to evaluate the pollution situation. The results showed that the Cr emissions from solid waste were the highest and mostly came from industrial sludge, accounting for 76.

Full-scale thermophilic aerobic co-composting of blue-green algae sludge with livestock faeces and straw.

A high incidence of harmful algal bloom in eutrophic surface waters causes many environmental problems. Thermophilic aerobic composting enables effective treatment and disposal of algal sludge that remains after the dewatering of algae slurries, and provides a value-added organic fertiliser. Previous studies have either only dealt with the composting of a single waste component or were conducted at a lab-/pilot-scale; however, this work is a comprehensive assessment of full-scale mechanized thermophilic aerobic co-composting of algal sludge and other typical biomass-based wastes, including chicken faeces and rice straw, in a water-rich rural area in the Tai lake basin, China.

Identification of a novel SDHB c.563 T > C mutation responsible for Paraganglioma syndrome and genetic analysis of the SDHB gene in China: a case report.

Background: Pheochromocytoma/paraganglioma (PPGL) is a rare neuroendocrine tumor. Succinate dehydrogenase (SDH) deficiency has been confirmed to be associated with PPGL in various studies. SDHB mutations play an important role in PPGL.

Determinants of carotid intima-media thickness in asymptomatic elders: a population-based cross-sectional study in rural China.

: To examine the mean carotid intima-media thickness (CIMT) and potentially relevant determinants of increased CIMT in elders. : Stroke-free and cardiovascular disease-free residents aged ≥65 years were recruited in a low-income population in China. B-mode ultrasonography was performed to measure CIMT.

NLR-A Simple Indicator of Inflammation for the Diagnosis of Left Ventricular Hypertrophy in Patients with Hypertension.

Unlabelled: We aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), brain natriuretic peptide (BNP), and left ventricular hypertrophy (LVH) in hypertension.

Methods: This study included 386 patients with hypertension. Mann-Whitney U test and multivariate binary logistic regression analysis were used to investigate the relationship between NLR, CRP, BNP, and LVH in patients with hypertension, as well as compare the levels of NLR, CRP, and BNP in the four configurations.

Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction.

Objective: Both hypertension and subclinical thyroid dysfunction (STD) have high prevalence and clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between hypertension and STD in Chinese.

Methods: We recruited 13,380 ostensible healthy participants (8,237 men and 5,143 women).