Synthesis and in vitro evaluation of antibacterial and antibiofilm activities of novel triphenylphosphonium-functionalized substituted pyrimidines.

The increase in the prevalence of antibiotic-resistant pathogens leads to a decrease in the number of antimicrobial agents for the treatment of infections and prompts researchers to search for new effective antimicrobial drugs. This study reports the synthesis of novel triphenylphosphonium-functionalized substituted pyrimidines and in vitro evaluation of their antibacterial and antibiofilm activity. Most of the synthesized derivatives showed high antibacterial activity (MIC = 0.

MORPHOLOGICAL JUSTIFICATION OF THE SIGNIFICANCE OF LUMBAR ARTERIES IN THE PREVENTION OF SPINAL CORD ISCHEMIA IN ATHEROSCLEROTIC LESIONS OF ABDOMINAL AORTA.

Objective: The aim: To investigate atherosclerosis of the abdominal part of the aorta and atherosclerosis of the lumbar arteries, aimed at improving surgical tactics during reconstructive interventions on the abdominal part of the aorta in patients with multifocal atherosclerosis.

Patients And Methods: Materials and methods: 20 autopsies were performed. The macro preparation consisted of the part of the abdominal aorta 1х1 sm taken along with a separated lumbar artery for 1-1,5 sm.

THE METHOD OF ATOMIC FORCE MICROSCOPY AS A POSSIBLE TOOL FOR TESTING THE BIOCOMPATIBILITY OF IMPLANTS IN TRAUMATOLOGY AND ORTHOPEDICS PRACTICE.

Objective: The aim: To establish the possibility of using the atomic force microscope (AFM) to predict the body's reaction to the implant.

Patients And Methods: Materials and methods: A total of 32 patients, 22 men and 10 women, the average age of the patients was 55±6 years, were included in the study. They performed pre- and post-operative testing of the biocompatibility of orthopedic implant materials with the patient's body with the help of AFM.

Recycling of Aluminum-Based Composites Reinforced with Boron-Tungsten Fibres.

High strength fibres of carbon, boron, silicon carbide, tungsten, and other materials are widely used to reinforce metal matrix composite materials. Carbon and boron fibers are usually used to reinforce light alloys based on aluminum and magnesium. Products made from these materials are characterized by high strength and rigidity and can be used for a long time.

Diagnostics of Gonococcal Infection in Ukraine: Current Challenges in Resource-Constrained Settings.

Objective: This study aimed to evaluate the compliance of laboratory diagnostics of gonorrhoea in Ukraine with the World Health Organization (WHO) laboratory manual.

Materials And Methods: A quantitative non-randomised cross-sectional descriptive postal survey was conducted to evaluate the diagnostics of gonorrhoea in sexually transmitted infections (STI) clinics in Ukraine.

Results: The survey provided data about diagnostics of Neisseria gonorrhoeae in STI clinics from 14 regions of Ukraine from January 2013 to September 2014.

COVID-19 PANDEMIC LIFESTYLE: STUDENTS MENTAL HEALTH CHALLENGES.

Objective: The aim: To determine how quarantine restrictions affect the lifestyle of Ukrainian students, and their mental health.

Patients And Methods: Materials and methods: 37 student essays were submitted to the university contest held at Lviv Polytechnic University in May-June 2020. They were analyzed with the help of qualitative thematic analysis and standard qualitative analysis method.

Air-flow control in fuel cells using delay-based load governor and feedforward augmented dynamic inversion.

The frequent and sudden increase of load in electric vehicles depletes oxygen from the fuel cell cathode, leading possibly to oxygen starvation. This paper presents the design of an air flow controller for fuel cell systems (FCS) that aims to replenish the depleted oxygen. A dynamic inversion is used as the feed-forward compensation for the disturbance effect coming from the load current change.

RADIAL HEAD ARTHROPLASTY WITH THE BIPOLAR IMPLANTS.

Objective: The aim: Of the research is to study of the stress distribution in the "bone-implant" system for various cases of elbow flexion and semipronation in the event of the radial head arthroplasty with the developed bipolar radial head (RH) implant and the bipolar KPS endoprosthesis.

Patients And Methods: Materials and methods: We developed a metal-metal bearing bipolar RH endoprosthesis providing an uncemented fixation due to a special porous coating and stem design. Using Solid Works software, we developed a geometrical model of the elbow joint with cartilaginous surfaces.

Comparative performance of commercial Amies transport media with and without charcoal for culture for gonococcal isolation and antimicrobial resistance monitoring in Ukraine.

Introduction: Culture is the only laboratory method that provides live gonococcal isolates for monitoring antimicrobial resistance. Many clinical settings do not have direct access to laboratories for the immediate processing of biological samples. Validated and quality-assured transport media are recommended to maintain the viability of .

Antimicrobial resistance and molecular epidemiological typing of Neisseria gonorrhoeae isolates from Kyrgyzstan in Central Asia, 2012 and 2017.

Background: Gonorrhoea and antimicrobial resistance (AMR) in Neisseria gonorrhoeae are significant public health concerns globally. Nearly no gonococcal AMR data are available from Central Asia, and no data from Kyrgyzstan has been published. We examined, for the first time, AMR and molecular epidemiology of N.

Antimicrobial resistance in Neisseria gonorrhoeae isolates and gonorrhoea treatment in the Republic of Belarus, Eastern Europe, 2009-2019.

Background: Limited antimicrobial resistance (AMR) data for Neisseria gonorrhoeae are available in Eastern Europe. We investigated AMR in N. gonorrhoeae isolates in the Republic of Belarus from 2009 to 2019, antimicrobial treatment recommended nationally, and treatment given to patients with gonorrhoea.

Comparison of deferred and bedside culture of : a study to improve the isolation of gonococci for antimicrobial susceptibility testing.

Background And Objectives: Antimicrobial resistance of is globally spread and threatening. Culturing of is the only method to collect live isolates for investigation antimicrobial resistance profile. Therefore, quality assessment of culture is essential for successful isolation of gonococci.

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants.

Background: Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity of the updated AC2 for the detection of CT and Neisseria gonorrhoeae (NG) on the automated Panther system (Hologic).

Methods: We examined 1004 clinical AC2 samples and 225 analytical samples spiked with phenotypically and/or genetically diverse NG and CT strains, and other potentially cross-reacting microbial species.

Genomic epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates from Ukraine, 2013-2018.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major health threat compromising the gonorrhoea treatment globally. AMR surveillance including whole genome sequencing (WGS)-based epidemiology provides ideal resolution to identify and describe AMR gonococcal clones, AMR determinants and populations, which can inform management guidelines and antimicrobial stewardship policies. Our aims were to, for the first time, elucidate the WGS-based epidemiology and characterize AMR determinants of gonococcal strains spreading in Ukraine, 2013-2018.

The Clinico-Epidemiological Profile of Patients with Gonorrhoea and Challenges in the Management of Neisseria gonorrhoeae Infection in an STI clinic, Ternopil, Ukraine (2013-2018).

Gonorrhea is the second most common sexually transmitted infection spreading worldwide and a serious public health problem. However, further data are required to improve the management of gonorrhea. Our aim was to review the features of gonococcal infection and characterize the challenges of its management.

High prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and particularly Trichomonas vaginalis diagnosed using US FDA-approved Aptima molecular tests and evaluation of conventional routine diagnostic tests in Ternopil, Ukraine.

Sexually transmitted infections (STIs) remain major public health problems globally. Appropriate laboratory diagnosis of STIs is rare in Ukraine. We investigated the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) using the US FDA-approved Aptima Combo 2 and Aptima TV assays and compared the results with the conventional routine diagnostic tests (CDTs) in Ukraine.

Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health concern globally. However, recent gonococcal AMR data from Eastern Europe are extremely limited and no AMR data for strains spreading in Ukraine have ever been internationally published. We investigated the AMR of N.

WHO laboratory validation of Xpert CT/NG and Xpert TV on the GeneXpert system verifies high performances.

Effective tests for diagnosis of sexually transmitted infections (STIs), used point of care to inform treatment and management decisions, are urgently needed. We evaluated the analytical sensitivity and specificity of the Xpert CT/NG and Xpert TV tests, examining 339 samples spiked with phenotypically and/or genetically diverse strains of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis, and other related species that may cross-react. The APTIMA Combo 2 test and APTIMA TV test were used as reference tests.

Justifying standards of workup in patients with occupational polyneuropathy caused by physical overload.

The authors examined algorithm of investigations in occupational pathology centers for suspected occupational polyneuropathy due to physical overload. Suggestions included a procedure to investigate the patients, including medical specialists consultations, set of laboratory and instrumental studies divided into obligatory and by special indications.

[Evaluating dependency of medical rehabilitation results in occupational polyneuropathy patiens on treatment strategy and work conditions].

The authors evaluated efficiency of rehabilitation in patients with upper limbs occupational polyneuropathy, in accordance with length of service under physical overstrain. The study was based on follow-up of 268 patients. Treatment was initiated after the patients discontinued work hazardous for health.

[Evaluation of risk factors for neurosensory deafness in workers engaged into gas transport enterprise in Far North].

Complex study of health state covered 666 workers of gas transport enterprise situated in Far North of Russian Federation, revealed risk factors of neurosensory deafness. Neurosensory deafness risk depends on intensity of occupational noise and length of service under exposure to noise, on worker's age, presence of arterial hypertension and type of lipid metabolism disorders. The study found no correlation between neurosensory deafness risk and duration of residence in Far North.

[Changes in clinical indices in patients in predisposition for pathological cicatrices formation].

Prophylaxis of ocurrence of pathological cutaneous cicatrices is one of actual problems of plastic surgery of head and neck. Cicatricial changes of tissues, as a consequence of operative interventions and various damaging causes (mechanical, thermal and chemical impact, ionizing irradiation, deep destructive inflammation), were depicted. Propensity for formation of pathological cicatrices we consider as the organism state, in which cicatricial changes occur as an answer for minimal trauma or spontaneously.

[Comparative description and retrospective analisis of modern methods of surgical wounds closure for intraoperative prophylaxis of development of pathologic cutaneous cicatrices].

The experience of application of various methods of closure was presented for the head and neck cutaneous wound surfaces after elective operative interventions. The variant of the postoperative results estimation and optimization of the wounds healing by primary closure was proposed.