Use of glucagon-like peptide 1 receptor agonist to sustain patients off basal-bolus insulin regimens.

Background: The 2024 Standards of Care in Diabetes recommend initiation of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) prior to starting basal insulin and to reconsider initiating a GLP-1 RA before starting bolus insulin if not already initiated. GLP-1 RA addition leads to improved glycemic benefits as well as risk reduction of cardiovascular and renal outcomes in patients with a history of these events. While there is evidence demonstrating the trends of insulin reduction or discontinuation following GLP-1 RA initiation, data regarding longer-term durability of GLP-1 RA use to sustain patients off bolus insulin are lacking.

Assessing Long-Term Quality of Life Concerns Through Survivorship Clinic in Head and Neck Cancer Patients.

Objective: To characterize the concerns of head and neck cancer (HNC) patients and discern changes in quality-of-life (QoL) during long-term follow-up.

Study Design: Retrospective review.

Setting: Survivorship clinic at a tertiary academic center.

Early Improved Functional Outcomes in Head and Neck Cancer Patients with Primary Tumor Detection.

Objectives: We characterize functional outcomes in head and neck cancer of unknown primary (CUP) based on primary site identification.

Methods: In this retrospective study, CUP cases were categorized as known primaries (KP) if a tumor was localized after diagnostic workup or persisting unknown primaries (UP). Age, sex, HPV status, diagnostic methods, and treatments regimens were collected.

Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years: A Randomized Clinical Trial.

Importance: The global prevalence of myopia is predicted to approach 50% by 2050, increasing the risk of visual impairment later in life. No pharmacologic therapy is approved for treating childhood myopia progression.

Objective: To assess the safety and efficacy of NVK002 (Vyluma), a novel, preservative-free, 0.

Timing of postoperative oral feeding after head and neck mucosal free flap reconstruction.

Objective: Fistula remains a common complication of upper aerodigestive tract reconstruction. Optimal timing of oral feeding is unknown and the impact of early feeding on swallow function and fistula rates remains controversial. The purpose of this study is to better understand the effects of "early feeding" on fistula rate and swallow in patients with free flap reconstruction of upper aerodigestive tract defects.

Quality improvement intervention to reduce time to postoperative radiation in head and neck free flap patients.

Background: Best-practice guidelines for head and neck cancer patients advise postoperative radiation therapy (PORT) initiation within 6 weeks of surgery. We report our institutional experience improving timeliness of adjuvant radiation in free-flap patients.

Methods: Thirty-nine patients met inclusion criteria in the 2017-2019 study period.

Evaluation of the blinq vision scanner for detection of amblyopia and strabismus.

Purpose: To report the results of a clinical study designed to evaluate the accuracy of the blinq pediatric vision scanner, which detects amblyopia and strabismus directly by means of retinal polarization scanning, unlike other vision screening devices, which infer possible disease based on detection of refractive risk factors.

Methods: Subjects 1-20 years of age were prospectively enrolled in this cross-sectional diagnostic accuracy study with planned enrollment of 200. All enrolled subjects were tested by individuals masked to the diagnosis, followed by complete ophthalmologic examination by pediatric ophthalmologists masked to the screening result.

Nanoparticle Delivered Anti-miR-141-3p for Stroke Therapy.

Ischemic stroke and factors modifying ischemic stroke responses, such as social isolation, contribute to long-term disability worldwide. Several studies demonstrated that the aberrant levels of microRNAs contribute to ischemic stroke injury. In prior studies, we established that miR-141-3p increases after ischemic stroke and post-stroke isolation.

Digital therapeutic improves visual acuity and encourages high adherence in amblyopic children in open-label pilot study.

Background: The effectiveness of amblyopia therapy can be limited by poor adherence. Dichoptic therapies are a new approach, but recent trials have demonstrated difficulty maintaining high adherence over extended periods of at-home treatment. We evaluated the efficacy and adherence of Luminopia One-a dichoptic treatment that applies therapeutic modifications to streaming content chosen by the patient.

Comparison between numerical and experimental results on thermoconvective instabilities of a high-Prandtl-number liquid.

The flow structuration of silicon oil (Prandtl number of 10.3) in a open cylindrical pool heated from the center of the surface is investigated numerically. Our purpose is to perform the numerical simulation of experimental results obtained by Favre [Phys.

Transcutaneous electrical stimulation versus traditional dysphagia therapy: a nonconcurrent cohort study.

Objective: The purpose of this investigation was to critically evaluate the efficacy of electrical stimulation (ES) in treating persons with dysphagia and aspiration.

Study Design: Nonconcurrent cohort study.

Methodology: The charts of 40 consecutive individuals undergoing ES and 40 consecutive persons undergoing traditional dysphagia therapy (TDT) were reviewed.

Ear of stimulation determines schizophrenia-normal brain activity differences in an auditory paired-stimuli paradigm.

Schizophrenia patients have abnormalities of auditory information processing, theoretically associated with dysfunction of neuronal excitation. Auditory paired-stimuli (S1-S2) paradigms are used to evaluate the nature of these abnormalities. It is unknown whether patients' abnormalities during S1-S2 paradigms are attributable to specific hemispheric differences in cortical processing.

The accuracy of the modified Evan's blue dye test in predicting aspiration.

Objectives/hypothesis: The modified Evan's blue dye test (MEBDT) is a relatively simple, inexpensive bedside procedure for the assessment of aspiration in the tracheotomized patient. Recent investigations have questioned its diagnostic accuracy. The purpose of the study was to evaluate the accuracy of the MEBDT in predicting aspiration among tracheotomized patients.

Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia.

Reduced auditory evoked response (AER) suppression in a paired-stimulus paradigm (where suppression equals the difference between S1 and S2 amplitudes divided by S1 amplitude) may index genetic liability for schizophrenia. The present report is a multiple-channel electroencephalographic (EEG) study of AER suppression among 20 normal and 20 schizophrenia subjects. The typical paired-stimulus paradigm was used to evoke time-locked AERs.

Response to the first stimulus determines reduced auditory evoked response suppression in schizophrenia: single trials analysis using MEG.

Objective: Reduced auditory evoked response (AER) suppression in a paired-stimulus paradigm may index genetic liability for schizophrenia. In most published studies of AER suppression, scores are based on data averaged over numerous stimulus presentations and recorded from few channels. It is unclear whether averaged data are equally representative of single trial responses in normal and schizophrenia subjects.

Cervimetry: a review of methods for measuring cervical dilatation during labor.

Several different methods of measuring cervical dilatation have been described. In this article, we review those methods and examine findings from studies using them. Although many instruments have been developed to measure cervical dilatation during labor and their use as a research tool has been established, no device has yet been successfully used for clinical obstetrics.

Hemispheric differences on auditory evoked response suppression in schizophrenia.

Using binaural stimuli, schizophrenia subjects have worse auditory evoked response (AER) suppression than normals in a paired-click paradigm. In this study we investigated hemispheric differences in AER suppression between groups using monaural and binaural stimulus presentation. Auditory evoked responses from 12 schizophrenia and 12 normal subjects were recorded with a 148-channel whole-head biomagnetometer.

Failure of dominant left-hemispheric activation to right-ear stimulation in schizophrenia.

Schizophrenia is associated with an absence of the lateralizations that typify the human brain. Previous evidence emphasized structural changes, particularly reduced asymmetry in extension and surface of the planum temporale, although gross structural deviations occur only in a minority of patients. The present study describes an absence of lateralization on a robust functional measure that characterized schizophrenia patients: healthy subjects but not schizophrenics displayed a contralateral left-hemispheric dominance of the auditory evoked magnetic field to right-ear auditory stimulation.

Retinopathy of prematurity in multiple-gestation pregnancies.

Purpose: To determine differences in incidence of retinopathy of prematurity between neonates of multiple-gestation and single-gestation pregnancies and to analyze differences in severity of retinopathy of prematurity among siblings of multiple-gestation pregnancies.

Methods: We reviewed the records of 149 neonates of multiple-gestation pregnancies and 691 single-gestation neonates screened for retinopathy of prematurity at one hospital from January 1, 1992, through December 31, 1995. The peak stage of retinopathy of prematurity was recorded for all infants.

The gamma band response may account for poor P50 suppression in schizophrenia.

The relationship between gamma band response (GBR) and P50 suppression was investigated among 10 DSM-IV schizophrenia patients and 10 normal comparison subjects using neuromagnetic and electrical recordings. In a paired-click paradigm, the neuromagnetic GBR and M100 suppression data improved schizophrenia-normal group separations over the typical electrical, vertex-recorded P50 suppression measure. The neuromagnetic GBR was also superior to the magnetic equivalent of P50 (M50) for discriminating schizophrenia and normal subjects.

The phenomenology of attention. 2. Brightness and contrast.

The effect of attention on perceived brightness and contrast was investigated in eight experiments. Attention was manipulated by engaging observers in an attention-demanding concurrent task (letter detection) or by directing attention to a location with a peripheral cue. In all of the dual-task manipulations, attention reduced the variability of responses.

The Phenomenology of Attention.

The effect of attention on perceived brightness and contrast was investigated in eight experiments. Attention was manipulated by engaging observers in an attention-demanding concurrent task (letter detection) or by directing attention to a location with a peripheral cue. In all of the dual-task manipulations, attention reduced the variability of responses.