[Knowledge and beliefs of the effect of menopause and estrogenic therapy on health. Study in women attending the Barros Luco-Trudeau Hospital].

The benefits of hormonal replacement therapy are widely known. In spite of this, the proportion of women under treatment is low. The study aims to evaluate the amount of knowledge that patients have, about menopause, and how it influences compliance with therapy.

[Double-blind method of the effect of menopause symptoms, lipid profile, and endometrial thickness of continuous therapy with estradiol valerate and medroxyprogesterone acetate].

Continuous combined therapy (CCT) using estrogens and progestagens has appeared as an alternative to avoid vaginal bleeding, which is characteristic of sequential hormone therapy, and the main reason for the stopping treatment. Irregular vaginal bleeding can occur at the beginning of treatment, but it has been observed that after a few months patients are in amenorrhea. Fifty postmenopausal women were studied in order to evaluate the clinical outcome.

[Symptomatic profile of the climacteric female. Clinical experience].

Unlabelled: To describe the symptoms of the climacteric female, 287 climacteric patients had their symptoms evaluated according to the criteria of Blatt-Kupperman for menopause. The median age was 50 years (P10 = 43 and P90 = 58). The main complaint was flushing in 46%, psychiatric symptoms in 17.

[Adverse effects of valproic acid in epileptic infants and adolescents].

Although valproic acid as well as its derivatives are effective in the treatment of some epileptic seizures, they are not free of adverse side effects. The purpose of this work was to describe the collateral clinical effects of valproic acid, the associated changes that take place in some serum laboratory parameters, and correlations among these adverse clinical effects, drug serum level and therapeutic response. One hundred patients aged 7 months to 19 years (average 5 year and 6 month old) were followed for at least 13 months.

[Menopause: a disease?].

As life expectancy lengthens, the period that women must live deprived of estrogens is also lengthened. Not only does this hormonal deficit produce the known vasomotor symptoms, but it also increases the risk of cardiovascular disease and bone fractures. The fact that replacement therapy using hormones during the postmenopause attenuates these risks has lead to the thought that we might be facing a disease.

[Variation of bone density in relation to age: analysis of 259 necropsies].

In a previous study we reported a relatively low incidence of hip fracture in our population compared to figures reported elsewhere and speculated that this could be related to differences in bone density. Accordingly, we measured bone density in 259 subjects at necropsy. In 172 males we found that bone density decreased from 0.

[Postmenopausal women: changes in plasma lipids with different estrogen replacement therapies].

We measured total, HDL and LDL cholesterol and triglycerides in 183 postmenopausal women before and 4 weeks after hormone therapy. Ethinyl estradiol or conjugated estrogens alone or in association with medroxyprogesterone, norethyndrone or norgestrel were used in different dosages either continuously or sequentially. Total cholesterol decreased from 206 to 196 mg/dl and HDL raised from 47 to 53 mg/dl (p less than 0.

[Surgical technic in the treatment of mandibular osteomyelitis].

Our experience with operative treatment of 70 patients with osteomyelitis of the mandible showed that the incision and drainage of soft-tissue abcesses combined with antibiotic therapy led to healing in 22 patients. More extensive measures, such as sequestectomy, decortication, resection of whole areas of the mandible, and transplantation of autologous cancellous bone, however were necessary with 48 of the patients. A detailed description of the various operative techniques was presented; the respective indications were mentioned.