Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP knock-in mouse model of Alzheimer's disease.

Introduction: Reduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well-known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit nutrient-induced mitochondrial activity (NiMA) in cultured neurons. We now report NiMA disruption in vivo.

Dual career in sport and non-sport work: Exploring experiences of North American professional female ice hockey players.

Grounded in role strain theory, this study explored the dual career experiences of North American female ice hockey players who were also involved in full-time non-sporting work, focusing on factors that produced and reduced their role strain. We interviewed ten professional ice hockey players who held full-time non-sport jobs at the time of their interview. Our reflexive thematic analysis revealed that the multitude of factors leading to role strain among professional female working-athletes were notably significant, spanning societal expectations and environmental complexities.

Intra-articular injection of an extended-release flavopiridol formulation represents a potential alternative to other intra-articular medications for treating equine joint disease.

Objective: To establish the pharmacokinetics of the cyclin-dependent kinase-9 inhibitor flavopiridol in equine middle carpal joints, using an extended-release poly lactic-co-glycolic acid (PLGA) microparticle formulation.

Animals: 4 healthy horses without evidence of forelimb lameness.

Methods: A 6-week longitudinal pharmacokinetic study was conducted in 2 phases (6 weeks each) in 4 healthy horses.

University serial winning coaches' experiences with low performance and maladaptive team culture.

We sought to explore the strategies and behaviours employed by University serial winning coaches during seasons of both low performance and a maladaptive team culture. We interviewed seven University team sport coaches and subsequently analyzed the data using a reflexive thematic analysis (RTA). Results indicated that our coaches generally felt unprepared for the unexpected and challenging season, leading to increased stress and decreased psychological well-being.

The Use of General Anesthesia in Revision Joint Arthroplasty.

Background: Several studies have suggested that spinal anesthesia gives superior outcomes for primary total joint arthroplasty (TJA). However, there is a lack of available data regarding contemporary general anesthesia (GA) approaches for revision TJA utilized at high-volume joint arthroplasty centers.

Methods: We retrospectively reviewed a series of 850 consecutive revision TJAs (405 revision total hip arthroplasties and 445 revision total knee arthroplasties) performed over 4 years at a single institution that uses a contemporary GA protocol and reported on the lengths of stay, early recovery rates, perioperative complications, and readmissions.

Salivary, lacrimal and nasal (SALANS) measure to assess side effects following radioactive iodine treatment: development, psychometric properties, and factor structure.

Purpose: This study aimed to develop and psychometrically evaluate a patient-reported outcome measure (PROM), SAlivary, LAcrimal, NaSal (SALANS), to document patients' symptoms after radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC).

Methods: We generated and iteratively revised SALANS items based on expert input, focus group discussions and feedback from cognitive testing (n = 17). We administered an initial SALANS measure with 39 items to patients diagnosed with DTC in the past two years (n = 105).

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP knock-in mouse model of Alzheimer's disease.

Introduction: Reduced brain energy metabolism, mTOR dysregulation, and extracellular amyloid-β oligomer (xcAβO) buildup characterize AD; how they collectively promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit N utrient-induced M itochondrial A ctivity (NiMA) in cultured neurons. We now report NiMA disruption .

"Just as curry is needed to eat rice, antibiotics are needed to cure fever"-a qualitative study of individual, community and health system-level influences on community antibiotic practices in rural West Bengal, India.

Objectives: To understand community antibiotic practices and their drivers, comprehensively and in contextually sensitive ways, we explored the individual, community and health system-level factors influencing community antibiotic practices in rural West Bengal in India.

Design: Qualitative study using focus group discussions and in-depth interviews.

Setting: Two contrasting village clusters in South 24 Parganas district, West Bengal, India.

Exploring the experiences and perceptions of coaches, athletes, and integrated support teams towards the management of three national Paralympic teams.

This study explored the experiences and perceptions of coaches, athletes, and integrated support teams towards the management of three Paralympic teams across North America and Europe. Six focus groups with athletes, three interviews with head coaches, and 10 interviews with support team members were conducted and analyzed using a reflexive thematic analysis. Our analysis resulted in three overarching themes to portray the coaches' role and behaviours in managing their (1) athletes, (2) integrated support teams, and (3) team as a collective unit.

Delivery of a community-based peer mentorship program for people with spinal cord injury at a rehabilitation center.

Introduction: Community-based spinal cord injury (SCI) organizations deliver peer mentorship programs in rehabilitation settings. Little is known on how these programs are delivered through the collaboration between community-based SCI organizations and rehabilitation institutions. This study aimed to identify barriers, facilitators, and collaboration processes within a SCI peer mentorship program provided by a community-based organization at a rehabilitation center.

The governance behaviours: a proposed approach for the alignment of the public and private sectors for better health outcomes.

Health systems are 'the ensemble of all public and private organisations, institutions and resources mandated to improve, maintain or restore health.' The private sector forms a major part of healthcare practice in many health systems providing a wide range of health goods and services, with significant growth across low-income and middle-income countries. WHO sees building stronger and more effective health systems through the participation and engagement of all health stakeholders as the pathway to further reducing the burden of disease and meeting health targets and the Sustainable Development Goals.

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.

Introduction: Neuronal nuclei are normally smoothly surfaced. In Alzheimer's disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauopathies.

Exploring coaches' experiences and perceptions of a virtual parasport coach mentorship program.

Partnering with a provincial coaching association in Canada, we explored the experiences and perceptions of 15 mentor and 29 mentee coaches who participated in a formal virtual parasport coach mentorship program. Data were gathered via focus groups and individual interviews and analyzed using a reflexive thematic analysis. Mentor coaches built a virtual relationship through mutual trust and respect and were perceived by their mentees as supportive, motivating, and knowledgeable.

Dysregulation of mTOR by tau in Alzheimer's disease.

Tau was discovered in the mid 1970's as a microtubule-associated protein that stimulates tubulin polymerization, and subsequently was shown to be expressed primarily in neurons, where it is most concentrated in axons. Interest in tau rose by the late 1980's, when it was shown to be the principal subunit of the neurofibrillary tangles (NFTs) that accumulate in Alzheimer's disease (AD) brain, and achieved new heights by the late 1990's, when numerous tau mutations were found to be highly penetrant for AD-related disorders that also are associated with NFTs and came to be known as non-Alzheimer's tauopathies. The role of tau in neurodegeneration is far more complex than whatever effects on neurons may be caused by NFTs, however, and here we review our work on dysregulation of mTOR by tau in AD.

Inceptor as a regulator of brain insulin sensitivity.

While historically viewed as an insulin insensitive organ, it is now accepted that insulin has a role in brain physiology. Changes in brain insulin and IGF1 signaling have been associated with neurological diseases, however the molecular factors regulating brain insulin sensitivity remain uncertain. In this study, we proposed that a recently described protein, termed Inceptor, may play a role in brain insulin and IGF1 resistance.

Preoperative Nutritional Laboratory Values, Demographics, and Wound Healing Following Facial Trauma Surgery: Which Variables Predict Postoperative Complications?

In individuals who have sustained maxillofacial trauma, inadequate nutrition is often a sequela and may lead to complications. The purpose of this study was to investigate the association between preoperative laboratory values and postoperative complications in patients with maxillofacial trauma requiring surgical intervention. A retrospective cohort study of patients with maxillofacial trauma requiring surgical repair from 2014 to 2020 was performed at a single academic Level I Trauma Center.

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.

Introduction: Neuronal nuclei are normally smoothly surfaced. In Alzheimer's disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauopathies.

Extracellular Tau Oligomers Damage the Axon Initial Segment.

Background: In Alzheimer's disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating polarity and functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from axonal proteins and initiates action potentials. Toxic tau species, including extracellular oligomers (xcTauOs), spread tau pathology from neuron to neuron by a prion-like process, but few other cell biological effects of xcTauOs have been described.

Localization, induction, and cellular effects of tau phosphorylated at threonine 217.

Introduction: Tau phosphorylation at T217 is a promising Alzheimer's disease (AD) biomarker, but its functional consequences were unknown.

Methods: Human brain and cultured mouse neurons were analyzed by immunoblotting and immunofluorescence for total tau, tau , tau , tau , and tau . Direct stochastic optical reconstruction microscopy (dSTORM) super resolution microscopy was used to localize tau in cultured neurons.

Analysis of Unmet Information Needs Among Patients With Thyroid Cancer.

Importance: Counseling prior to thyroid cancer (TC) treatment is an essential component of informed consent. An informed patient affects treatment-related expectations and patient engagement, factors that contribute significantly to patient-reported quality-of-life outcomes.

Objective: To describe experiences with pretreatment counseling among survivors of TC and to test factors associated with self-reported treatment meeting expectations.

A Scoping Review of Mixed Methods Research About Physical Activity for Children With Disabilities.

The purpose of this scoping review was to examine how mixed methods research (MMR) has been applied in adapted physical activity (APA) research about children and adolescents age 5-18 years with a disability. Six electronic databases were searched to retrieve relevant studies published between 2003 and 2020. Sixty-four studies were identified and analyzed.