Prognostic scoring using cytomorphometry and lymph node status of patients with breast carcinoma.

Applying morphometry on FNA smears may lead to meaningful prognostic subgrouping of breast carcinomas. A statistical analysis of the cytomorphometric and clinical data of 73 patients with breast carcinoma was performed. By multivariate analysis, taking into account various prognostic factors, it was shown that variations in nuclear area and the presence of axillary metastases were the most important prognosticators.

Computation of preoperative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears.

Morphometric analysis of 23 follicular tumors (13 adenomas and 10 carcinomas) and 10 metastatic lesions from follicular thyroid carcinomas resulted in the identification of five significant parameters between the carcinoma and adenoma groups. With a classification rule using these features, the probability of a histologic diagnosis of adenoma versus carcinoma was computed for each case. Using threshold values of probabilities of 0.

The cytology of medullary carcinoma of the thyroid with spindle cell pattern.

The cytological picture of medullary carcinoma of the thryoid is characterized by so-called triangular cells with abundant cytoplasm and eccentrically situated nuclei. In the May-Grünwald-Giemsa stained smear the cytoplasm may contain azurophilic granules. Amyloid can usually be demonstrated.

The action of 3-hydroxyanthranilic acid and other tryptophan metabolites on stimulated human lymphocytes.

Short term cultures of phytohemagglutinin stimulated lymphocytes were used to study effects of tryptophan metabolites of the kynurenine pathway at the cellular level. Only the metabolites 3-hydroxyanthranilic acid and 3-hydroxykynurenine demonstrated an effect when (3H) thymidine was used to monitor the response. Morphological examination of the cultures did not clearly reveal an effect.