Bioreactions at the tissue/hydroxyapatite interface.

The events at the hydroxyapatite implant material/tissue interface in the rat middle ear were studied by light microscopy, autoradiography, morphometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray microanalysis. Deposition of calcium, partially in the form of calcium phosphate, was found at the interface. Resorption of the implant material occurred as the result of mono- and multinuclear phagocyte activity.

Acute otitis media. An animal experimental study.

This paper describes an investigation performed to study the middle ear events ensuing from Staphylococcus aureus induced infection in the middle ear cavity of the rat. To obtain an evaluation at both the cell and the tissue level, scanning electron microscopy, transmission electron microscopy and histology were used. Staphylococcus aureus infection appears to be characterized by five major events: (i) cellular response, (ii) humoral response, (iii) mucociliary response, (iv) fibroblastic response, (v) bony response.

Heterogeneity of concanavalin A binding by mouse peritoneal macrophages.

The binding of the lectin concanavalin A (Con A) to the cell surface of monocytes and macrophages collected from the stimulated peritoneal cavity of mice was investigated electron microscopically with horseradish peroxidase-gold as an indirect marker. Individual cells were identified by the cytochemical localization of peroxidatic (PO) activity. In monocytes and monocyte-derived macrophages with PO activity in cytoplasmic granules, the degree of Con A binding was lower than in resident macrophages with PO activity in the rough endoplasmic reticulum and nuclear envelope.