Sidedness is not a prognostic factor in an unselected cohort of patients with colon cancer but prognosis for caecal carcinoma is worse - A multivariate analysis of a large single institution database.

Purpose: Sidedness has emerged as a prognostic factor for metastatic colorectal cancer treated with modern systemic therapies. This study investigates whether it is also relevant for an unselected patient cohort including all stages.

Methods: All consecutive patients admitted with colon cancer between 1995 and 2018 were retrieved from an institution-held database.

Significant decrease of the pathological stage I rectal carcinoma in the era of neoadjuvant therapy-A matter of concern.

Background: Neoadjuvant treatment (nTx) for rectal cancer is commonly reserved for UICC stages II/III. Patients with stage I tumours (T1-2N0M0) are not candidates for nTx. The accuracy of treatment allocation depends on the precision of clinical staging, which is liable to understaging and overstaging.

Correction to: Long-term results achieved by guideline-based stage-dependent management of anal cancer in a non-HIV population.

The authors of the article mentioned above found out errors on the Table 4 concerning the number and survival rates of patients with incomplete radiotherapy.

Long-term results achieved by guideline-based stage-dependent management of anal cancer in a non-HIV population.

Purpose: Therapy of anal cancer follows national and international guidelines that are mainly derived from randomized trials. This study aimed to analyze long-term results of stage-dependent treatment of anal cancer in a non-selected patient cohort.

Patients And Method: All consecutive patients treated for anal cancer between 2000 and 2015 were retrieved from a prospective database.

Long-term outcome of extralevator abdominoperineal excision (ELAPE) for low rectal cancer.

Purpose: Extralevator abdominoperineal excision (ELAPE) was introduced to improve outcomes for low-lying locally advanced rectal cancers (LARC) not amenable to sphincter preserving procedures. This study investigates prospectively outcomes of patients operated on with ELAPE compared with a similar cohort of patients operated on with conventional APE.

Methods: After the exclusion of patients without neoadjuvant therapy, in-hospital mortality, and incomplete metastatectomy, we identified 72 consecutive patients who had undergone either conventional APE (n = 36) or ELAPE (n = 36) for LARC ≤6 cm from the anal verge.

Outcome for stage II and III rectal and colon cancer equally good after treatment improvement over three decades.

Purpose: This study aimed to investigate the outcome for stage II and III rectal cancer patients compared to stage II and III colonic cancer patients with regard to 5-year cause-specific survival (CSS), overall survival, and local and combined recurrence rates over time.

Methods: This prospective cohort study identified 3,355 consecutive patients with adenocarcinoma of the colon or rectum and treated in our colorectal unit between 1981 and 2011, for investigation. The study was restricted to International Union Against Cancer (UICC) stages II and III.

Subacute oral toxicity study of benzyl isothiocyanate in rats.

The subacute toxicity of benzyl isothiocyanate (BITC) was investigated in male rats given oral doses of 0, 50, 100 and 200 mg/kg body weight/day for 4 weeks. Body weight gain and food consumption were decreased with increasing doses of BITC. Haematological changes of toxicological relevance were observed in the highest dose group.

Toxicological evaluation of rapeseed products in a subacute feeding study in rats.

Groups of 15 male rats were fed ad libitum for 4 weeks standard diet containing 0, 2.5, 5 or 10% rapeseed protein isolate (RPI), 2.5, 5 or 10% rapeseed extraction residue (RER) or 10% casein.

[The prenatal toxicity of butenylisothiocyanate in rats].

Butenyl isothiocyanate (BylITC), the hydrolysis product of the glucosinolate gluconapin, present in various cruciferous vegetables and in rapeseed, was administered in oral doses of 0, 50, 100 and 150 mg/kg to pregnant rats on day 12 to 19 of gestation. Maternal toxicity was indicated by reduced body weight gain and increases in the weights of liver and kidneys. BylITC doses of 100 and 150 mg/kg caused retardation of fetal growth and ossification.

Effects of 5-vinyloxazolidine-2-thione on lactating rats and their sucklings.

5-vinyloxazolidine-2-thione (VOT) administered orally to lactating rats was found to be efficiently transferred to the sucklings via the milk. In mothers the exposure to VOT resulted in an increased percentage of neutrophils, a decreased percentage of lymphocytes and increases in the relative weights of liver and thyroid. Suckling rats showed a decreased number of leucocytes, increases in the relative weights of liver and thyroid and structural changes in the thyroid.

[Toxicological evaluation of saccharose carbonic acid esters in basic subchronic feeding trials with rats. 1. Effect of saccharose fatty acid polyester].

Groups of male and female rats received a sucrose fatty acid polyesters containing product (SPE) in their diet for 13 weeks at levels of 0, 5, 10 or 15%. Additional groups were pair-fed to the high-dose SPE-group (standard diet, 92.5%) or given food containing 7.

[Toxicological effect of a fatty acid mixture in rats].

The effects of a fatty acids mixture containing nearly 50% odd numbered fatty acids (PC-Säure) were studied in a subchronic toxicity test in male and female rats. The animals received PC-Säure in their diet at levels of 0, 1.25, 2.

[Toxicologic evaluation of sucrose carbonic acid esters in basic subchronic feeding studies in rats. 2. Effect of sucroacetoglycerides].

Groups of male and female rats received a sucroacetoglycerides containing product (SAG) for 3 months at dietary levels of 0, 2.5, 5 and 10%. Food consumption was initially increased in females at all SAG-levels.

[Dietary fiber. Effect on colon carcinogenesis].

The etiopathogenesis of colon carcinogenesis is supposed to be a two-step process consisting of initiation and promotion. In human nutrition the range of xenobiotics acting possibly as initiators occurs mostly in very low concentrations. Therefore, performing a one-factorial consideration they are not claimed seriously to account for initiation.

[Progress report. What can one expect from a "functional prenatal toxicology?"].

In the strategy of investigation applied and demanded in prenatal toxicology partial aspects have been overstressed until now, although here as well as in postnatal toxicology the problems should be viewed in its complexity (in this case, F1-generation in its several pre- and postnatal stages of development). Therefore, there was the urgent need to summarize the existing methods of functional investigation in the field of prenatal toxicology and to compare them with conventional morphological methods as to their meaningfulness and sensitivity. As a result, the routine introduction of clinical-functional investigations is demanded.

[The subacute toxicity of glucosylthiazolidine-4-carbonic acid in rats].

Glucosylthiazolidine-4-carbonic acid, an intermediate of the Maillard reaction between D-glucose and L-cysteine, was given in doses of 0, 25, 50 or 100 mg/kg b.w. by oral intubation to male and female rats for 21 days.

[Progress report. Factors influencing nutritional toxic effects].

The basis of the requirement for nutrio-toxicological model investigations is the result of many years of international experience. They are, however, limited for pragmatic reasons to standardized one-dimensional test conditions and can only be partially compared with the variable exposure conditions of man. Therefore, we have tried to review the practical significance of factors influencing nutrio-toxic effects.

[The subchronic toxicity of 5-vinyloxazolidine-2-thione in rats].

Groups of male and female rats received 5-vinyloxazolidine-2-thione (VOT) in their drinking water for 13 weeks at concentrations of 0, 10, 25, 50 or 100 mg/l and 0, 2.5 or 5 mg/l respectively. Compared with the controls, there were decreases in food intake and growth of females given VOT-doses of 10 mg/l and higher.

[The use of image analysis in nutritional toxicology--determination of goitrogenic effects].

The estimation of the colloid area in PAS-stained thyroid slices were used for the proof of goitrogenic dose-effect-relations in nutritional toxicology.