Publications by authors named "Bleskina M"
Importance: The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified.
Objective: To examine the efficacy of Bifidobacterium longum subsp infantis, Bifidobacterium animalis subsp lactis (BB-12), and Lactobacillus acidophilus (La-5) probiotics to prevent colonization with multidrug-resistant organisms or highly epidemic bacteria (MDRO+) and to shape the microbiome of preterm infants toward the eubiotic state of healthy full-term infants.
Design, Setting, And Participants: The multicenter, double-blinded, placebo-controlled, group sequential, phase 3 Priming Immunity at the Beginning of Life (PRIMAL) randomized clinical trial, conducted from April 2018 to June 2020, included infants with gestational age of 28 to 32 weeks at 18 German neonatal units.
Article Synopsis
- The study aimed to assess the effectiveness and safety of a new eye drop combination (Brinzolol Duo) for treating early stages of primary open-angle glaucoma (POAG).
- Both Brinzolol Duo and a standard treatment (Azarga) were given to patients twice daily for 84 days, showing that both significantly lowered intraocular pressure (IOP).
- Results indicated that both treatments had similar success rates with good tolerance among patients, confirming that Brinzolol Duo is as effective as Azarga in managing IOP in POAG patients.