Publications by authors named "Bleaney C"
Article Synopsis
- Cancer is caused by abnormal gene expression, and enhancers are key regulatory elements influencing this process, particularly in the development of esophageal adenocarcinoma (OAC).
- Using STARR-seq, researchers mapped the enhancer landscape in OAC and identified many active enhancers that correlate with gene activity and chromatin markers in both cancer cells and patient samples.
- The study highlights the role of specific enhancers and the transcription factor KLF5 in OAC, suggesting these elements could be crucial for understanding the disease and responding to targeted therapies.
United Kingdom and Ireland Oesophagogastric Cancer Group Cancer Update 2023.
Clin Oncol (R Coll Radiol)
September 2024
Modern advanced radiotherapy techniques have improved the precision and accuracy of radiotherapy delivery, with resulting plans being highly personalised based on individual anatomy. Adaptation for individual tumour biology remains elusive. There is an unmet need for biomarkers of intrinsic radiosensitivity that can predict tumour response to radiation to facilitate individualised decision-making, dosing and treatment planning.
View Article and Find Full Text PDFThe origin of human metaplastic states and their propensity for cancer is poorly understood. Barrett's esophagus is a common metaplastic condition that increases the risk for esophageal adenocarcinoma, and its cellular origin is enigmatic. To address this, we harvested tissues spanning the gastroesophageal junction from healthy and diseased donors, including isolation of esophageal submucosal glands.
View Article and Find Full Text PDFA correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View Article and Find Full Text PDFAim: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis.
Methods: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format.
Objective: To study the presentation, management and outcomes and to apply retrospectively the Pituitary Apoplexy Score (PAS) (United Kingdom (UK) guidelines for management of apoplexy) to a large, single-centre series of patients with acute pituitary apoplexy.
Design: Retrospective analysis of casenotes at a single neurosurgical centre in Liverpool, UK.
Results: Fifty-five patients [mean age, 52·4 years; median duration of follow-up, 7 years] were identified; 45 of 55 (81%) had nonfunctioning adenomas, four acromegaly and six prolactinomas.