Heterologous expression of the human wild-type and variant Na 1.8 (A1073V) in rat sensory neurons.

Background: Silent inflammatory bowel disease (IBD) is a condition in which individuals with the active disease experience minor to no pain. Voltage-gated Na (Na ) channels expressed in sensory neurons play a major role in pain perception. Previously, we reported that a Na 1.

Measurement of polarization observables , , and in and photoproduction off quasi-free nucleons.

The target asymmetry , recoil asymmetry , and beam-target double polarization observable were determined in exclusive and photoproduction off quasi-free protons and, for the first time, off quasi-free neutrons. The experiment was performed at the electron stretcher accelerator ELSA in Bonn, Germany, with the Crystal Barrel/TAPS detector setup, using a linearly polarized photon beam and a transversely polarized deuterated butanol target. Effects from the Fermi motion of the nucleons within deuterium were removed by a full kinematic reconstruction of the final state invariant mass.

The Costs and Benefits of Mindfulness and Reappraisal in Daily Life.

Unlabelled: Reappraisal and mindfulness represent two fundamentally different but interconnected ways of dealing with one's emotions: whereas reappraisal is aimed at changing one's thoughts and emotions, mindfulness is aimed at immediately changing, but appreciating them. Despite this difference, prior research has shown that both are beneficial for one's affective well-being. However, research on the spontaneous use of reappraisal and mindfulness in daily life found that they might be differentially associated with positive and negative affect, with reappraisal and mindful attention being more strongly associated with increased positive affect and mindful acceptance with decreased negative affect.

Stress buffering after physical activity engagement: An experience sampling study.

Objectives: While encountering daily hassles is a normative experience, it poses a threat to individuals' daily affective well-being. However, physical activity engagement may help to reduce the current stress-related impact on affective well-being (i.e.

When and How to Regulate: Everyday Emotion-Regulation Strategy Use and Stressor Intensity.

Unlabelled: Contextual factors shape emotion regulation (ER). The intensity of emotional stimuli may be such a contextual factor that influences the selection and moderates the effectiveness of ER strategies in reducing negative affect (NA). Prior research has shown that, on average, when emotional stimuli were more intense, distraction was selected over reappraisal (and vice versa).

Impact of discrimination and coping on Veterans' willingness to seek treatment for physical and mental health problems.

Objective: This study aimed to provide insight into health disparities among Veterans by (a) documenting the prevalence of physical and mental health problems in a racially diverse sample of Veterans, (b) comparing Veterans' willingness to seek treatment for various physical and mental health conditions, and (c) examining the impact of discrimination and coping on willingness to seek treatment.

Method: Veterans reported on current physical and mental health symptoms and the importance of treatment for various health conditions. Patterns were examined in the full sample ( = 334, 32% female) and the subsample who reported hazardous alcohol use in the past year ( = 116, 33% female).

Perspectives on resilience: Trait resilience, correlates of resilience in daily life, and longer-term change in affective distress.

Resilience describes successful adaptation in the face of adversity, commonly inferred from trajectories of well-being following major life events. Alternatively, resilience was conceptualised as a psychological trait, facilitating adaptation through stable individual characteristics. Both perspectives may relate to individual differences in how stress is regulated in daily life.

A blind spot in mental healthcare? Psychotherapists lack education and expertise for the support of adults on the autism spectrum.

Most autistic adults experience mental health problems. There is a great demand for psychotherapeutic support that addresses the specific needs of autistic individuals. However, people with autism encounter difficulties trying to access diagnostic and therapeutic services.

Spinal cord injury-mediated changes in electrophysiological properties of rat gastric nodose ganglion neurons.

In preclinical rodent models, spinal cord injury (SCI) manifests as gastric vagal afferent dysfunction both acutely and chronically. However, the mechanism that underlies this dysfunction remains unknown. In the current study, we examined the effect of SCI on gastric nodose ganglia (NG) neuron excitability and on voltage-gated Na (Na) channels expression and function in rats after an acute (i.

Emotion regulation dynamics in daily life: Adaptive strategy use may be variable without being unstable and predictable without being autoregressive.

Recent research has demonstrated the adaptiveness of variability in emotion regulation (ER) by showing that variability between and, when controlled for depression, within ER strategies as assessed via the standard deviation was associated with less negative affect. We first replicated associations with negative affect by using the relative standard deviation, which is less confounded with the mean. Second, following research on affect dynamics, we extended this line of research by examining five additional ER dynamic measures covering ER instability, inertia, predictability, differentiation, and diversity.

Why do my thoughts feel so bad? Getting at the reciprocal effects of rumination and negative affect using dynamic structural equation modeling.

Rumination means to perseveratively think about one's negative feelings and problems. It is a response to affective distress that is often referred to as maladaptive emotion regulation. According to the response styles theory and control theory, rumination may further prolong and exacerbate affective distress.

Observation of the pη^{'} Cusp in the New Precise Beam Asymmetry Σ Data for γp→pη.

Data on the beam asymmetry Σ in the photoproduction of η mesons off protons are reported for tagged photon energies from 1130 to 1790 MeV (mass range from W=1748  MeV to W=2045  MeV). The data cover the full solid angle that allows for a precise moment analysis. For the first time, a strong cusp effect in a polarization observable has been observed that is an effect of a branch-point singularity at the pη^{'} threshold [E_{γ}=1447  MeV (W=1896  MeV)].

Change in mental health symptoms during the COVID-19 pandemic: The role of appraisals and daily life experiences.

Objective: When confronted with major threats, people often experience decline in well-being. The central purpose of this study was to identify mechanisms underlying change of well-being in times of threat, using the example of the COVID-19 pandemic, with a focus on appraisals of the pandemic and affective states, stress, as well as mindfulness in daily life.

Method: We conducted a study across 3.

The relationship between cannabis use and cognition in people diagnosed with first-episode psychosis.

Cannabis use is highly prevalent among young people diagnosed with first-episode psychosis (FEP), however, its impact on cognition is still unclear. The aim of the present study was to examine the association of cannabis use with cognition in people diagnosed with FEP. We extended previous research findings by operationalising the comorbid cannabis use, considering recency of cannabis use and use of other illicit substances and including people with a broad spectrum of psychotic diagnoses.

Altered physiology of gastrointestinal vagal afferents following neurotrauma.

The adaptability of the central nervous system has been revealed in several model systems. Of particular interest to central nervous system-injured individuals is the ability for neural components to be modified for regain of function. In both types of neurotrauma, traumatic brain injury and spinal cord injury, the primary parasympathetic control to the gastrointestinal tract, the vagus nerve, remains anatomically intact.

Gastric vagal afferent neuropathy following experimental spinal cord injury.

Dramatic impairment of gastrointestinal (GI) function accompanies high-thoracic spinal cord injury (T3-SCI). The vagus nerve contains mechano- and chemosensory fibers as well as the motor fibers necessary for the central nervous system (CNS) control of GI reflexes. Cell bodies for the vagal afferent fibers are located within the nodose gangla (NG) and the majority of vagal afferent axons are unmyelinated C fibers that are sensitive to capsaicin through activation of transient receptor potential vanilloid-1 (TRPV1) channels.

Thinking mindfully: How mindfulness relates to rumination and reflection in daily life.

Mindfulness is a state of awareness comprising an attentional focus on the present moment and a nonjudgmental stance. It is associated with affective well-being and assumed to facilitate adaptive emotion regulation. To support this claim at the within-person level, we investigated associations between 2 mindfulness facets (present-moment attention and nonjudgmental acceptance), 2 emotion-regulation strategies varying in adaptiveness (rumination and reflection), and positive and negative affect in everyday life using data from 2 experience-sampling (ESM) studies.

Gastrointestinal dysfunction after spinal cord injury.

The gastrointestinal tract of vertebrates is a heterogeneous organ system innervated to varying degrees by a local enteric neural network as well as extrinsic parasympathetic and sympathetic neural circuits located along the brainstem and spinal axis. This diverse organ system serves to regulate the secretory and propulsive reflexes integral to the digestion and absorption of nutrients. The quasi-segmental distribution of the neural circuits innervating the gastrointestinal (GI) tract produces varying degrees of dysfunction depending upon the level of spinal cord injury (SCI).

Reading thoughts and feelings in other people: Empathic accuracy across adulthood.

Empathy is a multifaceted trait. One facet is cognitive empathy, the ability to accurately infer others' thoughts and feelings (also referred to as empathic accuracy). It is associated with markers of positive adjustment, such as satisfaction with social relationships, in earlier phases of the lifespan.

Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach.

The nodose ganglion (NG) is the main parasympathetic ganglion conveying sensory signals to the CNS from numerous visceral organs including digestive signals such as gastric distension or the release the gastrointestinal peptides. The response characteristics of NG neurons to ATP and ADP and pharmacological interrogation of purinergic receptor subtypes have been previously investigated but often in NG cells of undetermined visceral origin. In this study, we confirmed the presence of P2X3 and P2Y1 receptors and characterized P2X and P2Y responses in gastric-innervating NG neurons.

Mix it to fix it: Emotion regulation variability in daily life.

Emotion regulation (ER) strategies are often categorized as universally adaptive or maladaptive. However, it has recently been proposed that this view is overly simplistic: instead, adaptive ER involves applying strategies variably to meet contextual demands. Using data from four experience-sampling studies (Ns = 70, 95, 200, and 179), we tested the relationship between ER variability and negative affect (NA) in everyday life.

Higher well-being is related to reduced affective reactivity to positive events in daily life.

Within the study of emotions, researchers have increasingly stressed the importance of studying individual differences in emotion dynamics and emotional responding and the way these relate to more stable differences in well-being. However, there is no clear picture regarding affective reactivity to positive events and how different emotional reactions relate to differences in well-being, particularly higher levels of well-being. Theoretical work and empirical findings from different lines of research (e.

Outpatient Psychotherapy for Adults with High-Functioning Autism Spectrum Condition: Utilization, Treatment Satisfaction, and Preferred Modifications.

Many adults with autism spectrum condition (ASC) desire outpatient psychotherapy (PT). This study compared reasons for seeking PT, experiences with PT, and modifications preferred with respect to PT of individuals with ASC to non-autistic individuals with depression (MDD). Furthermore, factors predictive for treatment satisfaction were identified in individuals with ASC.

Emotion differentiation dissected: between-category, within-category, and integral emotion differentiation, and their relation to well-being.

Emotion differentiation, the ability to describe and label our own emotions in a differentiated and specific manner, has been repeatedly associated with well-being. However, it is unclear exactly what type of differentiation is most strongly related to well-being: the ability to make fine-grained distinctions between emotions that are relatively closely related (e.g.

Pathways to happiness are multidirectional: Associations between state mindfulness and everyday affective experience.

Mindfulness is commonly defined as a multidimensional mode of being attentive to, and aware of, momentary experiences while taking a nonjudgmental and accepting stance. These qualities have been linked to 2 different facets of affective well-being: being attentive is proposed to lead to an appreciation of experiences as they are, and thus to positive affect (PA). Accepting unpleasant experiences in a nonjudgmental fashion has been hypothesized to reduce negative affect (NA).