Publications by authors named "Blanka Majchrzycka"
Article Synopsis
- - The organization of genomes in all organisms is crucial for efficient function, and recent Hi-C methods allow us to explore the 3D arrangement of chromatin across various species.
- - This review compares chromatin folding in bacteria, archaea, mammals, and plants, highlighting both similarities and differences that shed light on the evolution and function of spatial chromatin domains.
- - The study reveals that while 3D chromatin structure is ancient and plays a key role in gene regulation, evolutionary changes can lead to significant variations in genome organization across different organisms.
The selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well-defined. In this study, we use Cut&Run to examine genomic binding locations for TICRR/TRESLIN and MTBP, the human orthologs for the yeast DNA replication initiation factors Sld3 and Sld7. We mapped TRESLIN and MTBP binding in HCT116 colorectal cancer cells using asynchronous and G1 synchronized populations.
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- Conventional treatments for follicular thyroid cancer (FTC) often fail, prompting a study to find mutations that could act as new molecular markers and therapeutic targets for the disease.
- In a patient cohort, mutations were found in 69% of individuals diagnosed with FTC, with older patients showing a higher likelihood of being mutation-positive.
- The study identified a variety of mutations, particularly in the tyrosine kinase domain, highlighting the need for further research on their role in FTC development and treatment options.
DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication.
View Article and Find Full Text PDFOvarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel.
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