Publications by authors named "Blanca L Checa-Fernandez"
This series of two papers is devoted to the effect of organic dye (methylene blue, MB; or methyl orange, MO) adsorption on the surface of either bare or citrate-coated magnetic iron oxide nanoparticles (IONPs) on their primary agglomeration (in the absence of an applied magnetic field) and secondary field-induced agglomeration. The present paper (Part I) is focused on physicochemical mechanisms of dye adsorption and adsorption-induced primary agglomeration of IONPs. Dye adsorption to oppositely charged IONPs is found to be mostly promoted by electrostatic interactions and is very sensitive to pH and ionic strength variations.
View Article and Find Full Text PDFIn this paper, it is proposed that polymer-coated magnetic nanorods (MNRs) can be used with the advantage of a double objective: first, to serve as magnetic hyperthermia agents, and second, to be used as magnetic vehicles for the antitumor drug doxorubicin (DOX). Two different synthetic methodologies (hydrothermal and co-precipitation) were used to obtain MNRs of maghemite and magnetite. They were coated with poly(ethyleneimine) and poly(sodium 4-styrenesulfonate), and loaded with DOX, using the Layer-by-Layer technique.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the creation and analysis of two types of magnetic nanoparticles: inorganic magnetic nanoparticles (MNPs) and biomimetic magnetic nanoparticles (BMNPs) produced from bacteria.
- BMNPs are advantageous for drug delivery due to their ability to load positively charged drugs at neutral pH and release them in acidic tumor environments, while MNPs excel in providing magnetic transport and hyperthermia treatment.
- The research aims to combine both particles in varying concentrations to optimize stability, drug transport capabilities, and enhance hyperthermia response, ultimately proposing a highly effective drug delivery system.