Publications by authors named "Blanca Fabre-Estremera"
Objectives: Despite clinical guidelines do not recommend the use of point-of-care testing (POCT) glucometers for diagnostic purposes yet, the analytical performance is continuously improving. Thus, we evaluate the technical accuracy and clinical concordance of POCT glucometers during an oral glucose tolerance test (OGTT) in children for prediabetes and diabetes diagnosis in a comparison study.
Methods: Pediatric patients with an OGTT indication who attended the Diabetes Unit between December 2020 and September 2021 were recruited for this prospective observational study.
Article Synopsis
- The study validated the Mindray high-sensitivity cardiac troponin I (hs-cTnI) assay by assessing its limits of blank (LoB) and detection (LoD), precision, linearity, analytical specificity, and sex-specific reference limits.
- Key findings showed that the assay meets the standards of a high-sensitivity test, with a LoB and LoD both under 0.1 ng/L, good precision (1.2-3.8% variation), and acceptable specificity for various interfering substances.
- The 99th percentile upper reference limits for cardiac troponin were determined to be 10 ng/L overall, with 5 ng/L for females and 12 ng/L for males, confirming the
Objectives: Growth differentiation factor 15 (GDF-15) levels increase due to systemic inflammation and chronic disease burden. Since these biological processes are pathogenic factors of malnutrition, we examined the prospective association between GDF-15 serum levels and subsequent malnutrition in older adults.
Methods: We used data from 723 women and 735 men aged ≥65 years [mean age (SD): 71.
Background: Our study addressed the diagnostic performance of the Atellica® IM High-Sensitivity Troponin I (hs-cTnI) assay for the rapid rule-out of myocardial infarction (MI) using a single hs-cTnI measurement at presentation in patients presenting to a US emergency department (ED).
Methods: This was a prospective, observational, cohort study of consecutive ED patients with suspected acute coronary syndrome, using 12-lead electrocardiogram and serial hs-cTnI measurements ordered on clinical indication (SAFETY, NCT04280926). ST-segment elevation MI patients were excluded.
Background: High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are biomarkers of myocardial infarction and heart failure, respectively, and indicate cardiovascular risk. Since low physical activity (PA) and sedentary behavior (SB) are also associated with higher cardiovascular risk, and this association could be a consequence of higher levels of cardiac biomarkers, we examined the association of device-measured movement behaviors with hs-cTnT and NT-proBNP in older men and women without major cardiovascular disease (CVD).
Methods: We used data from 1939 older adults from the Seniors-ENRICA-2 study.