Publications by authors named "Blanca Esther Garcia Figueroa"

Article Synopsis
  • Anti-αGal IgE antibodies are responsible for αGal-syndrome (AGS), an allergic condition that develops in individuals after hard tick bites, leading to increased sensitivity to αGal.
  • The study explores the creation of polymeric αGal-glycoconjugates aimed at inhibiting these IgE antibodies, with promising results in both human serum samples and a mouse model.
  • The findings indicate that a minimum of 27 αGal residues is required for effective inhibition, and the specific polymeric conjugate DP1000-RA0118 demonstrated significant reduction of anti-αGal IgE antibodies, supporting its potential for clinical application in treating AGS.
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Background: As the frequency of natural rubber latex (NRL) allergy has increased, attempts have been made to diminish exposure in high-risk patients. Despite some good results, complete NRL avoidance was not possible, so latex immunotherapy was developed.

Objective: To examine variations in immunologic parameters, clinical efficacy, and safety of NRL sublingual immunotherapy (SLIT).

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