Publications by authors named "Blanca Calle-Ciborro"
IL-6 is an important cytokine involved in metabolic, immunological, and cell-fate responses. It is released upon stimulation by skeletal muscle cells through partially characterized mechanisms. In some cell types, IL-6 has been reported to activate a positive feedback loop involving endocytic vesicles, but evidence is mostly based on transcription and signal transduction mechanisms and is very scarce in muscle cells.
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- The study investigates how calcium (Ca) signals in human skeletal muscle cells influence the secretion of the protein IL-6, which is important for the systemic effects of physical activity.
- Researchers used primary muscle cultures and assessed Ca signals through fluorescence microscopy, while measuring IL-6 release with the ELISA technique.
- Findings revealed that ATP stimulates IL-6 secretion through various Ca channels and signaling pathways, highlighting the complexity of post-transcriptional regulation involving Ca mobilization and related receptors.