Changes in rod and cone-driven oscillatory potentials in the aging human retina.

Purpose: We recorded oscillatory potentials (OPs) to document how age impacts on rod- and cone-driven inner retina function.

Methods: Dark- and light-adapted electroretinogram (ERG) luminance-response functions were recorded in healthy human subjects aged 20 to 39, 40 to 59, and 60 to 82 years. Raw ERG traces (0.

Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina.

Purpose: With age, retina function progressively declines and A2E, a constituent of the toxin lipofuscin, accumulates in retinal pigment epithelial (RPE) cells. Both events are typically exacerbated in age-related retina diseases. We studied the effect of dietary docosahexaenoic acid (DHA, C22:6n-3) supplementation on these events, using a transgenic mouse model (mutant human ELOVL4; E4) displaying extensive age-related retina dysfunction and massive A2E accumulation.