An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene in neurons.

L1 cell adhesion molecule (L1CAM) is well-known for its importance in nervous system development and cancer progression. In addition to its role as a plasma membrane protein in cytoskeletal organization, recent studies have revealed that both transmembrane and cytosolic fragments of proteolytically cleaved vertebrate L1CAM translocate to the nucleus. studies indicate that nuclear L1CAM affects genes with functions in DNA post-replication repair, cell cycle control, and cell migration and differentiation, but its role and how its nuclear levels are regulated is less well-understood.

"Why do you want your child to have braces?" Investigating the motivations of Hispanic/Latino and white parents.

Introduction: Many psychological, social, and cultural factors influence parents' motivation to seek orthodontic care for their children. In this study, we used Q methodology to identify and categorize shared motives and determine whether cultural differences exist between Hispanic/Latino (H/L) and non-Hispanic/Latino, white (W) parents.

Methods: The fundamental question posed to the parents was "Why do you want your child to have braces?" Q methodology involves 3 stages.

High-throughput directed self-assembly of core-shell ferrimagnetic nanoparticle arrays.

Magnetic nanoparticles (MNPs) provide a set of building blocks for constructing stimuli-responsive nanoscale materials with properties that are unique to this scale. The size and the composition of MNPs are tunable to meet the requirements for a range of applications including biosensors and data storage. Although many of these technologies would significantly benefit from the organization of nanoparticles into higher-order architectures, the precise placement and arrangement of nanoparticles over large areas of a surface remain a challenge.