Outcomes of Selective Reduction of DCDA Twins Complicated by PV-PROM Compared with Expectant Management: A Case Series and Review of the Literature.

Objective: To report the outcomes of selective reduction (SR) in dichorionic twins complicated by pre-viable, premature rupture of membranes (PV-PROM).

Methods: Retrospective case series. Ultrasound database was searched for cases of dichorionic twin pregnancy with PV-PROM, either managed conservatively or with SR.

In Utero diagnosis and management of a fetus with homozygous α-Thalassemia in the second trimester: a case report and literature review.

Alpha thalassemia with the absence of 4 α-globin genes leads to fetal hydrops and fetal death from anemia. Historically considered a lethal condition, optimal in utero management of homozygous α-thalassemia is unclear. A fetus of Filipino descent at 26 weeks gestation presented with ultrasound evidence of anemia.

Accuracy of reported family history and effectiveness of medical record requests in genetic counseling for Alzheimer disease.

The University of British Columbia Hospital Clinic for Alzheimer Disease and Related Disorders (UBCH-CARD) invests significant effort to obtain medical records for the confirmation of patient-reported family histories of dementia. The effectiveness of requesting these records was assessed through a review of the 275 requests made by UBCH-CARD genetic counselors during the 24-month period of January 1, 2005-December 31, 2006. The results were categorized according to outcome.

A randomized trial of oral misoprostol in premenopausal women before hysteroscopy.

Objective: To determine if the use of oral misoprostol in premenopausal women undergoing diagnostic hysteroscopy produces a clinically important difference in pre-procedural cervical dilatation.

Methods: At a tertiary care hospital, premenopausal women undergoing diagnostic hysteroscopy were randomized to receive either 400 microg of misoprostol or a vitamin B6 placebo orally 12 hours before the procedure. Patients were stratified on the basis of parity.

Outcomes of pregnancies complicated by hyperemesis gravidarum.

Objective: To evaluate maternal and neonatal outcomes among women with hyperemesis during pregnancy.

Methods: A population-based retrospective cohort study was conducted among women with singleton deliveries between 1988 and 2002. Hyperemetic pregnancies were defined as those requiring one or more antepartum admissions for hyperemesis before 24 weeks of gestation.

Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy.

Objective: To identify risk factors for hyperemesis requiring hospital admission during pregnancy.

Methods: Data from a population-based cohort of all deliveries in Nova Scotia, Canada between 1988 and 2002 were obtained from the Nova Scotia Atlee Perinatal Database. Women with 1 or more antepartum admissions for hyperemesis were compared with women with no admissions for hyperemesis.