A Randomized Controlled Trial Examining the Effect of Topical Refrigerant Spray on the Perception of an Instantaneous Noxious Stimulus.

Purpose: Topical refrigerant spray is commonly used with routine hand injections despite mixed evidence about its efficacy in reducing the pain experience. We hypothesize that the use of topical refrigerant spray decreases the pain experience of an instantaneous noxious stimulus.

Methods: Eighty adult volunteer participants were enrolled in the study.