Novel Drug-Drug Interaction of Potential Rifabutin-Induced Edoxaban Failure: A Case Report.

To report an incident of a breakthrough deep vein thrombosis (DVT) and potential example of a drug-drug interaction in a patient treated with edoxaban and rifabutin who was being treated for respiratory tuberculosis. A 76-year-old male presented with anemia requiring transfusion and subsequent shortness of breath that was later diagnosed to be respiratory tuberculosis. He experienced a prolonged hospital stay due to persistently positive respiratory samples and a complicated social situation that required continuous hospitalization for approximately five months.

One change, different effects: the impacts of reducing clerkship length.

Background: Medical school curricula are constantly evolving and change has potential positive and negative effects. At East Tennessee State University Quillen College of Medicine, a broader understanding of the effects of a curriculum change (reduction in clerkship length for one transitional year) was explored.

Methods: A broad, system-wide evaluation was used to evaluate impacts on all stakeholders.