[Structural and metabolic aspects of heterogenicity of the ventricular cardiac myocytes in coronary insufficiency].

The paper shows comparative analysis of structural-metabolic changes of the ventricular cardiac hystiocytes during transitional restriction of blood supply, which leads to relapsing myocardium hypoperfusion, ischemia and even to cardiac infarction. We have established that an increase of the myocardium arrhythmogenicity, damage of myocardium electrophysiological activity and coronary deficiency are caused by pathologically intensified structural-metabolic heterogeneity of cardiomyocites. The chronic ischemic heart disease is worsening the situation by gradual accumulation of the metastructure changes of heart's working cells.

[The characteristics of the morphofunctional restructuring of the aortic endothelium in food-related atherosclerosis and hyperadrenalinemia].

Morphofunctional reorganization was studied of endothelium during the stage of formation of alimentary atherosclerosis and in experimental hyperadrenalinemia using transmission electronic microscopy and histochemistry together with silver nitrate impregnation of aortal endothelial monolayer. Certain morphofunctional equivalents have been established for the vascular wall exposure to the above factors, indicative of their unequalability and possibility of potentiation under combination. In both cases, an interrelationship similar in character has been shown between intensity of the endothelial reciprocal response and its regional morphofunctional features.

[The transport-trophic support of myocardial function in the modelling of chronic ischemic heart disease].

Using a model of chronic ischemic heart disease (recurring coronary insufficiency against the background of chronic hypercholesterolemia), regularities were studied of the microcirculation rearrangements in the myocardium. Employed in the studies were methods of light optics, electron microscopy, injection, as was morphometry. All structural and functional links of the myocardial microcirculation system were put to study, such as resistive, metabolic and blood-drawing segments of the microhemocirculatory channel, intramyocardial tracts of lymph outflow, and interstitium as a direct carrier of the intratissue milieu, as well as subepicardial portion of the lymphatic network of the heart.

[The lymph and blood microcirculatory beds of the pancreas in the early period of experimental acute pancreatitis].

Results of the study evidence that in the early period of acute experimental pancreatitis (AEP)--from 10 minutes to 2 hours--changes in acino-capillary complex consist in compensatory-adaptive reaction and are related to metabolic disorders. Abortive interstitial oedema disappears in 20-30-minutes, dilated lymphatic vessels being visible macroscopically. Further progress of oedema with consequent focal haemorrhagic pancreonecrosis is possible in case of insufficient lymphatic drainage.

[The structural bases of the cardiotoxic action of the anti-tumor antibiotic carminomycin].

The authors substantiate morphological and structural-functional basis of the cardiotoxic effect of the antitumor anthracycline antibiotic carminomycin after its single intraperitoneal administration in maximum tolerable doses. Results indicate that the cause of development of cardiac failure after administration of carminomycin to experimental animals in the development of an alternative and plastic cardiac failure prevalence of type I.

[The morphological aspects of the protective action of enterosorbent K(2)9 during the use of the antitumor anthracycline antibiotic carminomycin].

The authors substantiate morphologically the protector effect of K(2)9 enterosorbent during its parallel use with the antitumour anthracyclin antibiotic carminomycin. The agent was administered intraperitoneally in animals at the maximum tolerable dose. Use of the K(2)9 enterosorbent reduces the cardiotoxic effect of carminomycin.

[Changes in the bioenergetic processes and immunoglobulin transport in the stomach tissues of rats after vagotomy].

Data are reported on changes of bioenergetic processes and immunoglobulin transport in gastric tissues after bilateral subdiaphragmatic transsection of the vagal nerves. It was established that the mucosa and muscle membrane of the stomach showed a reduced activity of the glycolysis enzyme. There was also abnormal transport of autogenic immunoglobulins, namely increased penetration of immunoglobulins into the connective-tissue stroma of the mucosa and the surface of epithelium into the gastric cavity.

[Kidney ultrastructure in experimental lithiasis and nephrocalcinosis].

An experimental electron-microscopic study of the kidneys was carried out in experimental oxamide nephrolithiasis in rabbits and hypervitaminosis D in rats. The most pronounced changes were revealed in the proximal and the distal convoluted tubules. It is suggested that cytosomes and lysosome-like bodies possibly participated in stone formation and nephrocalcinosis.