Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Deciphering the Competitive Charge Storage Chemistry of Metal Cations and Protons in Aqueous MnO-Based Supercapacitors.

The complex charge storage mechanisms in aqueous MnO-based supercapacitors have posed significant challenges to a comprehensive understanding of their chemical behavior. In this study, we employed Au-core@MnO-shell nanoparticle-enhanced Raman spectroscopy, alongside electrochemical analysis and X-ray absorption, to systematically investigate the competitive charge storage chemistry of protons and cations within the inner and outer layers of δ-MnO under alkaline conditions. Our findings reveal that δ-MnO operates through a dual mechanism: the intercalation and deintercalation of metal cations dominate charge storage in the inner layer, while surface chemisorption of protons governs the outer layer.

Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study.

Background: Acute myocardial injury is defined by elevated cardiac troponin (cTn) levels with a rising and/or falling pattern, and is associated with increased mortality risk compared to patients without myocardial injury. The role of β-blockers in patients with acute myocardial injury remains unclear.

Methods: This multicenter, retrospective cohort study used data from the Tianjin Health and Medical Data Platform to assess the impact of early β-blocker use on 1-year all-cause mortality and major adverse cardiovascular events (MACE) in acute myocardial injury patients, employing a new user and target trial emulation design.

Multi-omics informed mathematical model for meropenem and tobramycin against hypermutable Pseudomonas aeruginosa.

Hypermutable P. aeruginosa isolates frequently display resistance emergence during treatment. Mechanisms of such resistance emergence have not been explored using dynamic hollow-fiber studies and multi-omics-informed mathematical modeling.

Nano-confined controllable crystallization in supramolecular polymeric membranes for ultra-selective desalination.

Innovations in self-assembly and aggregate engineering have led to membranes that better balance water permeability with salt rejection, overcoming traditional trade-offs. Here we demonstrate a strategy that uses multivalent H-bond interactions at the nano-confined space to manipulate controllable and organized crystallization. Specifically, we design amphiphilic oligomers featuring hydrophobic segments with strongly polar end-capped motifs.

Robotic Assistance for Precise Spinal Injections: Development and Clinical Verification.

Robot-assisted surgical systems have shown promising results and better patient outcomes in pedicle screw instrumentation and percutaneous needle interventions. Many commercial robotic assistance systems are available for the aforementioned procedures. However, there is only limited literature on robotic spinal injection and needle delivery.

Design and Development of a Universal Accessory for Instruments and Implants Navigation in Image-Guided Spine Surgeries.

To enhance the integration of diverse non-navigated instruments and implants with Image-Guided Spine Surgery (IGSS) systems and address the challenges of closed-implant and line-of-sight issues with existing navigation adaptors, we developed a Universal Accessory (UA) featuring a radially symmetrical collet chuck mechanism. Utilizing SS 17-4 PH and Al 6061-T6 materials, the UA meets clinical criteria such as durability, sterilization compatibility, and biocompatibility. The UA's performance was thoroughly tested using an Optical Tracking System (OTS), a Coordinate Measuring Machine (CMM), and a spine training model involving surgeons.

Toward Decision Support System for Lower Limb Endovascular Revascularization.

Vascular surgeons take decisions on the revascularization technics when surgery is needed for patients with Lower Extremities Arterial Disease (LEAD). This decision requires experience, good knowledge of official recommandations and new technics and an exhaustive description of the patient status. The Case Based Reasoning (CBR) is a good candidate to clinical decision support.

The optimal route search in Bengaluru city transport using Hamilton circuit algorithm.

Traffic congestion is a common transportation issue all over the globe, especially in India's large cities. One of the primary causes of traffic congestion is the sheer volume of private vehicles that travel on city streets and the extensive use of public transportation. The lack of additional road capacity also makes it worse.

Exosome tropism and various pathways in lung cancer metastasis.

Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize to various organs, thereby amplifying its detrimental impact and fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication and regulating physiological functions due to their specificity and stability.

The role of molecular biomarkers in the diagnosis, prognosis, and treatment stratification of oral squamous cell carcinoma: A comprehensive review.

One of the most common cancers targeting the area of the head and neck is oral squamous cell carcinoma (OSCC), carrying a heavy global health cost. With a high incidence of metastasis and recurrence, the outlook for OSCC remains dismal despite advancements in treatment. This has sparked an investigation into molecular biomarkers, which have the potential to improve early diagnosis, forecast patient outcomes, and direct therapeutic approaches.

Comparison of Efficacy of the Combination of Topical Tazarotene Gel and Oral Fluconazole Versus Oral Fluconazole Monotherapy in the Treatment of Onychomycosis.

Background: Onychomycosis is a chronic fungal infection of the nails of toes and fingers, with an ongoing search for appropriate and more officious treatment modalities because the currently applied regimens are far from perfect.

Objective: The objective of this study was to compare the efficacy of the combination of topical tazarotene 0.1% gel and oral fluconazole with weekly oral fluconazole monotherapy in the treatment of OM.

When Chest Pain Isn't What It Seems: A Case of Cardiac Lymphoma.

Primary cardiac lymphoma (PCL) is an exceedingly rare malignancy, often presenting with heart failure or arrhythmias. This case report describes a 61-year-old male with a history of diabetes, hypertension, and ischemic heart disease who presented with symptoms mimicking acute coronary syndrome (ACS). Despite significant stenosis in the left anterior descending artery (LAD), advanced imaging, including cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) scan, revealed a large infiltrative mass consistent with PCL.

Candida-Associated Renal Papillary Necrosis Following Severe COVID-19 Infection.

Candida-associated renal papillary necrosis is rare. The few cases described previously were secondary to candidemia, especially in immunocompromised hosts. We describe two patients who presented with hydroureteronephrosis and were diagnosed with candida-associated renal papillary necrosis.

A multi-objective optimization framework through genetic algorithm for hyperthermia-mediated drug delivery.

This study presents an approach to the multi-objective optimization of hyperthermia-mediated drug delivery using thermo-sensitive liposomes (TSLs) for the treatment of hepatocellular carcinoma. The research focuses on addressing the non-optimal coupling methods that combine thermal treatments and chemotherapy by employing a Multi-Objective Genetic Algorithm (MOGA) optimization process, in order to identify the right combination of design variables to achieve better treatment outcomes. The proposed model integrates Computational Fluid Dynamics (CFD) analysis using the Pennes' Bioheat equation for tissue heating and a convection-diffusion model for drug delivery.

Liquid Nitrogen as a Novel Treatment for Gingival Depigmentation: A Case Report.

Gingiva is an important part of a smile, and it is considered the most frequently pigmented tissue in the oral cavity. Although gingival pigmentation is physiologic in most cases, it is one of the common causes of esthetic concerns in patients with gummy smiles. Hence, the demand for cosmetic therapy of gingival melanin pigmentation has become common.

Evaluating strategies for global respiratory pandemic control at ports: a modelling study.

Background: Heavy reliance on container shipping during the COVID-19 pandemic with lockdown implementation and air travel bans placed substantial pressure on shipping crews and ports. Long waiting times at ports, substantial economic losses and massive supply chain disruption of essential and medical goods were observed. To minimise this for future pandemic preparedness, we explore the use of quarantining and testing of crews preboarding instead of quarantining at port calls or during voyages.

Characterization of a Bioactive Chitosan Dressing: A Comprehensive Solution for Different Wound Healing Phases.

Wound management has made significant advances over the past few decades, particularly with the development of advanced dressings that facilitate autolytic debridement, the absorption of wound exudate, and protection from external bacteria. However, finding a single dressing that effectively addresses all four phases of wound healing─hemostasis, inflammation, proliferation, and remodeling─remains a major challenge. Additionally, biofilms in chronic wounds pose a substantial obstacle by shielding microbes from topical antiseptics and antibiotics, thereby delaying the healing process.

A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer.

Muscle-invasive bladder cancer (MIBC), a highly heterogeneous disease, shows genomic instability and a high mutation rate, making it difficult to treat. Recent studies revealed that cancer stem cells (CSCs) play a critical role in MIBC frequent recurrence and high morbidity. Previous research has shown that Cyclooxygenases-2 (COX-2) is particularly highly expressed in bladder cancer cells.

Identification of DNA Methylation Differences in Pituitary Tissues of Sichuan White Geese Using Whole-Genome Bisulfite Sequencing (WGBS).

To explore the impact of epigenetic modifications on egg-laying traits in geese, we employed genome-wide bisulfite sequencing (WGBS) to analyze DNA methylation patterns in pituitary tissues of high-(HYP) and low-yield (LYP) Sichuan White geese. We achieved high-quality sequencing data (mean 19.09 Gb raw reads, 15.

[A study on the effects of learning on the properties of rats hippocampal-prefrontal connections in a memory task].

The transmission and interaction of neural information between the hippocampus and the prefrontal cortex play an important role in learning and memory. However, the specific effects of learning memory-related tasks on the connectivity characteristics between these two brain regions remain inadequately understood. This study employed microelectrode recording to obtain local field potentials (LFPs) from the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) in eight rats during the performance of a T-maze task, assessed both before and after task learning.

Corrigendum to "POS-074 SERUM NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN, EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN ASPHYXIATED TERM NEONATES AT LAGOS STATE UNIVERSITY TEACHING HOSPITAL" [ Volume 7, Issue 2, Supplement, February 2022, Page S31].

[This corrects the article DOI: 10.1016/j.ekir.

HepG2 cells do not express xanthine oxidoreductase (XOR): Implications for XOR and uric acid-related research.

Although the relative extent of xanthine oxidoreductase (XOR) varies considerably in human tissues, the greatest specific activity is reported in the liver and intestines. Unlike murine models, where primary hepatocytes are readily available, human counterparts are not. As such, investigators often utilize the human carcinoma cell line HepG2 for in vitro experimentation as these cells proliferate well in culture medium.

Evaluation of the Factors Influencing the Survival Times of Chinese Patients with Probable Creutzfeldt-Jacob Disease - China, 2020-2022.

What Is Already Known About This Topic?: The clinical durations of sporadic Creutzfeldt-Jacob disease (sCJD) patients typically do not exceed 2 years, though considerable variation exists. The factors influencing survival among Chinese sCJD patients remain incompletely characterized.

What Is Added By This Report?: A comprehensive evaluation of 31 factors across 7 categories was conducted in a retrospective cohort of 300 probable Chinese sCJD patients.