Publications by authors named "Bjoern Ambrosius"
Article Synopsis
- The study investigates the natural course and healthcare implications of acute porphyria using anonymized claims data from over 8 million patients in Germany between 2015 and 2020.
- It found a prevalence of 79.8 per million for acute porphyria, with 12.9 per million having active cases, and highlighted that these patients had higher comorbidity and healthcare utilization compared to the general population.
- The results underscore the need for healthcare strategies that address the unique challenges faced by acute porphyria patients, especially in light of the recent introduction of the preventive therapy givosiran in Europe.
In this unit, we describe in detail the most common methods used to break immunological tolerance for central myelin antigens and induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats as an animal model of multiple sclerosis. The resulting disease course ranges from an acute monophasic disease to a chronic relapsing or chronic progressive course, which strongly resembles the human disease. These models enable the study of cellular and humoral autoimmunity against major antigenic epitopes of the myelin basic protein, myelin oligodendrocyte glycoprotein, or proteolipid protein.
View Article and Find Full Text PDFIn multiple sclerosis (MS) and its corresponding animal models, over-activity of the renin-angiotensin system (RAS) has been reported and pharmacological RAS blockade exerts beneficial effects. The RAS generates a number of bioactive angiotensins, thereby primarily regulating the body's sodium homeostasis and blood pressure. In this regard, angiotensin IV (AngIV), a metabolite of the RAS has been shown to modulate inflammatory responses.
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